Background: Helicobacter pylori (H.Pylori) are a most common infection throughout the world. A high prevalence of H.Pylori infection has recently been reported in diabetic patients; but data on relation between H.Pylori and glycemic control (HbA₁C level) are not enough and are controversial. This study aimed to investigate this relation in diabetic patients referred to endocrine clinics of Shaheed Labafinegad and Shohada Tajrish hospitals between years of 1386-87.

Materials and Methods: This is an experimental (before-after) study, it was done on 61 type II DM patients with or without dyspepsia symptoms that HP Infection identified by serologic test (IgG Anti H. Pylori) and then all patients were treated with Quadriple therapy (Bismuth, Metronidazole, Tetracycline, Omeperazole). HbA₁C was measured before eradication H.Pylori and 2month after eradication H.Pylori. Eradication of H.Pylori infection was documented by UBT (Urea Breath test). Mean of HbA₁C level before and after H.Pylori eradication was compared by SPSS and paired T Test.

Results: In this study mean age was 52.4 ± 10.04 years. The number of male was 39 (63.9%) and female was 22(36.1%) duration of diabetes was 8.7 ± 5.5 years. H.Pylori infection was eradicated in all of the patients (100%). Mean of HbA₁C level before eradication was 8.6 ± 1.2 and after eradication was 7.9 ± 1.2; and their difference was 0.7 that is statistically were significant (p<0.05).

Conclusion: According to this study, possible influence of H.Pylori eradication on glycemic control in diabetic patients (reduction in HbA₁C); it is recommended to more studies about screening diabetic patients to identify and eradication H.Pylori infection to assess better glycemic control.