|
Postbiotics; Next-generation Probiotics
|
Marzieh Sanaei1    , Mohammad Hossein Yazdi * 2, Mehdi Mahdavi3 |
1- PhD in Pharmaceutical Biotechnology, Department of Pharmaceutical Biotechnology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2- Associate Professor, Biotechnology Research Center, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3- Assistant Professor, Vaccine Research Center, Tehran University of Medical Sciences, Tehran, Iran |
|
|
Abstract: (1955 Views) |
Although for a long time it was thought that the health benefits of probiotics depend on their viability but, in the last decade, studies have shown that the passive form of these bacteria (non-viable), microbial fractions, and cell lysates also offer physiological benefits to the host. Thus from 2011 onwards, new terms such as postbiotic have emerged, indicating that viability is not necessary for health-promoting effects of probiotics. Postbiotics refers to soluble factors secreted by live bacteria or released after bacterial lysis including, enzymes, peptides, polysaccharides, organic acids, teichoic acids, and cell surface proteins. Treatment of some diseases in human and animals has been demonstrated in case of using these postbiotics. Identification of postbiotics can be associated with the production and development of drug formulations without live bacteria. With this review, we aim to provide a comprehensive picture of the postbiotics, their production and identification methods, and their application in food and pharrmaceutical industries.
|
|
| Keywords: Probiotics, Postbiotics, Cell lysates, Bacterial-derived factors, Health benefits. |
|
|
Full-Text [PDF 366 kb]
(1054 Downloads)
|
Type of Study: Research |
Subject:
Special
Received: 2022/08/01 | Accepted: 2022/08/01 | Published: 2022/08/01
|
|
|
|
|
|
|
| Add your comments about this article |
|
|
|
