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:: Volume 4, Issue 2 (5-2015) ::
aumj 2015, 4(2): 129-136 Back to browse issues page
The Synthesis and Characterization of Magnetic Nano Gold and Their Application for Antibody Immobilization
A. Ahmadi, N. Zarghami, H. Shirazi, N. Poorbagher, K. Omidfar
Endocrinology research center,Tehran University of Medical Sciences,Iran , omidfar@tums.ac.ir
Abstract:   (3557 Views)

Background: Gold (Au) Fe oxide core-shell nanostructure is a major class of nanoscale material that has attracted a considerable attention due to the biotechnological and biomedical applications and specific properties. Methods: Here we synthesized the magnetite nanoparticles (MNPs) with an average size of 10-12 nm in diameter using the chemical co-precipitation of Fe2+ and Fe3+ in strong alkaline material. Then, an Au coated Fe oxide core-shell nanocomposite with an average diameter of 18-20 nm was produced in the presence of sodium citrate as the reducing agent. The structures of Au shell and magnetic core (Au–Fe oxide) were studied by transmission electron microscopy (TEM), X-ray diffraction (XRD) and fourier transformed infrared spectroscopy (FTIR). Results: Results showed that the NPs were agglomerate-free and shaped regularly, with a narrow sized distribution. The Au-coated Fe oxide NPs exhibited a surface plasmon resonance peak in the range of 500-650 nm with a remarkable peak at 550 nm. Conclusions: Immobilization studies with antibody (Ab) demonstrated that the Au Fe oxide core-shell nanostructure can be used to immobilize Ab, making them valuable for biomedical and biological applications.

Keywords: Antibody, Au Fe oxide NPs, Core-shell nanocomposite, Immobilization
Full-Text [PDF 302 kb]   (1933 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/08/04 | Accepted: 2015/08/04 | Published: 2015/08/04
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ahmadi A, zarghami N, shirazi H, poorbagher N, omidfar K. The Synthesis and Characterization of Magnetic Nano Gold and Their Application for Antibody Immobilization. aumj. 2015; 4 (2) :129-136
URL: http://aums.abzums.ac.ir/article-1-313-en.html

Volume 4, Issue 2 (5-2015) Back to browse issues page
نشریه دانشگاه علوم پزشکی البرز Alborz University Medical Journal
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