Volume 6, Issue 4 (11-2017)                   aumj 2017, 6(4): 227-240 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Soleimani N. Molecular Biology of Aminoglycoside and Relationship of Aminoglycoside Modifying Enzymes with Altering Resistance. aumj 2017; 6 (4) :227-240
URL: http://aums.abzums.ac.ir/article-1-675-en.html
Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran , N_soleimani@sbu.ac.ir
Abstract:   (4496 Views)
The clinical significance of aminoglycosides is due to effect of gram-negative bacteria, staphylococcus aureus and some streptococcus. It is most application in the treatment of infections caused by facultative aerobic gram-negative bacilli. Combination of an aminoglycoside with beta-lactam or glycopeptide has synergistic effect on sensitive bacteria and can be effective in the treatment. Today, some bacteria have multiple resistances to some antibiotics, including aminoglycosides. Acquired resistance to aminoglycosides in Gram-negative bacteria and gram-positive bacteria have been reported. Three resistance mechanisms involve a change in the position of the ribosomal binding of drugs, decreasing drug permeability and enzymatic drug inactivation. So, Identification of resistance mechanisms and find new functional groups is important in reducing resistance.
Full-Text [PDF 405 kb]   (5869 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/01/10 | Accepted: 2018/01/10 | Published: 2018/01/10

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Alborz University Medical Journal

Designed & Developed by : Yektaweb