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:: Volume 6, Issue 4 (11-2017) ::
aumj 2017, 6(4): 227-240 Back to browse issues page
Molecular Biology of Aminoglycoside and Relationship of Aminoglycoside Modifying Enzymes with Altering Resistance
Neda Soleimani
Assistant Professor Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran , N_soleimani@sbu.ac.ir
Abstract:   (455 Views)
The clinical significance of aminoglycosides is due to effect of gram-negative bacteria, staphylococcus aureus and some streptococcus. It is most application in the treatment of infections caused by facultative aerobic gram-negative bacilli. Combination of an aminoglycoside with beta-lactam or glycopeptide has synergistic effect on sensitive bacteria and can be effective in the treatment. Today, some bacteria have multiple resistances to some antibiotics, including aminoglycosides. Acquired resistance to aminoglycosides in Gram-negative bacteria and gram-positive bacteria have been reported. Three resistance mechanisms involve a change in the position of the ribosomal binding of drugs, decreasing drug permeability and enzymatic drug inactivation. So, Identification of resistance mechanisms and find new functional groups is important in reducing resistance.
Keywords: Aminoglycoside, Antibiotic resistant, Gene
Full-Text [PDF 405 kb]   (116 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/01/10 | Accepted: 2018/01/10 | Published: 2018/01/10
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Soleimani N. Molecular Biology of Aminoglycoside and Relationship of Aminoglycoside Modifying Enzymes with Altering Resistance. aumj. 2017; 6 (4) :227-240
URL: http://aums.abzums.ac.ir/article-1-675-en.html


Volume 6, Issue 4 (11-2017) Back to browse issues page
نشریه دانشگاه علوم پزشکی البرز Alborz University Medical Journal
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