Volume 11, Issue 4 (Autumn 2022)
aumj 2022, 11(4): 524-531 |
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Mahmoodi S M M, Javanmardi F. Evaluation of Antibacterial Effect and Synergism of Prodigiosin with a Number of Common Antibiotics. aumj 2022; 11 (4) :524-531
URL: http://aums.abzums.ac.ir/article-1-1593-en.html
URL: http://aums.abzums.ac.ir/article-1-1593-en.html
1- Assistant Professor, Department of Microbiology, Faculty of Basic Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran
2- Assistant Professor, Department of Biology, Faculty of Basic Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran
2- Assistant Professor, Department of Biology, Faculty of Basic Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran
Abstract: (1245 Views)
Aim and objective: Today, the main treatment for bacterial infections is the use of antibiotics, but due to side effects and increased antibiotic resistance, the use of complementary or alternative methods to treat infectious diseases has become particularly important.
Material and Method: In this study, prodigiosin pigment was produced by a strain of Seratia marcescens and its antibacterial effect on a number of gram-positive and gram-negative pathogenic bacteria was investigated by determining the MIC and MBC of the pigment. The synergism effect of pigment with a number of common antibiotics was also investigated.
Results: The results of this study showed that produced prodigiosin, at concentrations of 32, 64, 256 and 512 μg / ml could inhibit the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Klebsiella oxytoca respectively. The study of synergism phenomenon also showed that, this pigment has a synergistic effect with the antibiotics oxacillin, ceftriaxone and vancomycin.
Conclusion: According to the results, it seems that gram-positive bacteria are more sensitive to produced prodigiosin and also the synergistic effect of this pigment is mainly with antibiotics that affect the cell wall of bacteria. If the harmlessness and non-toxicity of this pigment is proven in living animal and human models, we can hope that this pigment will be used as a complementary drug or even as an alternative to antibiotics.
Material and Method: In this study, prodigiosin pigment was produced by a strain of Seratia marcescens and its antibacterial effect on a number of gram-positive and gram-negative pathogenic bacteria was investigated by determining the MIC and MBC of the pigment. The synergism effect of pigment with a number of common antibiotics was also investigated.
Results: The results of this study showed that produced prodigiosin, at concentrations of 32, 64, 256 and 512 μg / ml could inhibit the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Klebsiella oxytoca respectively. The study of synergism phenomenon also showed that, this pigment has a synergistic effect with the antibiotics oxacillin, ceftriaxone and vancomycin.
Conclusion: According to the results, it seems that gram-positive bacteria are more sensitive to produced prodigiosin and also the synergistic effect of this pigment is mainly with antibiotics that affect the cell wall of bacteria. If the harmlessness and non-toxicity of this pigment is proven in living animal and human models, we can hope that this pigment will be used as a complementary drug or even as an alternative to antibiotics.
Type of Study: Research |
Subject:
Special
Received: 2022/08/01 | Accepted: 2022/08/01 | Published: 2022/08/01
Received: 2022/08/01 | Accepted: 2022/08/01 | Published: 2022/08/01
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