1- Department of Obstetrics and Gynecolog, Alborz University of Medical Sciences, Karaj, Iran
2- Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran
3- Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran , mahnaz.jamee@gmail.com
Abstract: (1704 Views)
Reciprocal translocation carriers have reduced fertility, increased risk of spontaneous abortion or unbalanced karyotype in their offspring. Here, we report the inheritance of a translocation between chromosomes 12 and 16 in a family with a history of five consecutive blighted ova and an offspring with three cell lines of different genotypes. We assessed parental karyotypes and identified a heterozygous reciprocal translocation in the father (46, XY.t (12; 16) (q24.12; p13.2)). The t (12; 16) is associated with fetal wastage and may play a role in the etiology of the family's miscarriage. These findings can be used as an effective tool for reproductive guidance and genetic counseling.
Type of Study:
Research |
Subject:
Special Received: 2021/07/11 | Accepted: 2021/05/31 | Published: 2021/05/31