Balanced Reciprocal Translocation in A Case of Recurrent Miscarriage

Farahani, Masoumeh; Saee Rad , Samira; Ataei, Mina; Jamee, Mahnaz

doi:10.29252/aums.10.2.133

Volume 10, Issue 2 (Spring 2021) aumj 2021, 10(2): 133-136 | Back to browse issues page

‎ 10.29252/aums.10.2.133

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Farahani M, Saee Rad S, Ataei M, Jamee M. Balanced Reciprocal Translocation in A Case of Recurrent Miscarriage. aumj 2021; 10 (2) :133-136
URL: http://aums.abzums.ac.ir/article-1-1327-en.html

Balanced Reciprocal Translocation in A Case of Recurrent Miscarriage

Masoumeh Farahani¹

, Samira Saee Rad²

, Mina Ataei¹

, Mahnaz Jamee ^*³

1- Department of Obstetrics and Gynecolog, Alborz University of Medical Sciences, Karaj, Iran
2- Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran
3- Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran , mahnaz.jamee@gmail.com

Abstract: (1704 Views)

Reciprocal translocation carriers have reduced fertility, increased risk of spontaneous abortion or unbalanced karyotype in their offspring. Here, we report the inheritance of a translocation between chromosomes 12 and 16 in a family with a history of five consecutive blighted ova and an offspring with three cell lines of different genotypes. We assessed parental karyotypes and identified a heterozygous reciprocal translocation in the father (46, XY.t (12; 16) (q24.12; p13.2)). The t (12; 16) is associated with fetal wastage and may play a role in the etiology of the family's miscarriage. These findings can be used as an effective tool for reproductive guidance and genetic counseling.

Keywords: Mosaicism in fetus, Parental translocation, Reciprocal translocation, Recurrent miscarriages

Full-Text [PDF 1150 kb] (604 Downloads)

Type of Study: Research | Subject: Special
Received: 2021/07/11 | Accepted: 2021/05/31 | Published: 2021/05/31