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Balanced Reciprocal Translocation in A Case of Recurrent Miscarriage
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Masoumeh Farahani1    , Samira Saee Rad2 , Mina Ataei1 , Mahnaz Jamee * 3 |
1- Department of Obstetrics and Gynecolog, Alborz University of Medical Sciences, Karaj, Iran
2- Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran
3- Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran , mahnaz.jamee@gmail.com |
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Abstract: (1521 Views) |
| Reciprocal translocation carriers have reduced fertility, increased risk of spontaneous abortion or unbalanced karyotype in their offspring. Here, we report the inheritance of a translocation between chromosomes 12 and 16 in a family with a history of five consecutive blighted ova and an offspring with three cell lines of different genotypes. We assessed parental karyotypes and identified a heterozygous reciprocal translocation in the father (46, XY.t (12; 16) (q24.12; p13.2)). The t (12; 16) is associated with fetal wastage and may play a role in the etiology of the family's miscarriage. These findings can be used as an effective tool for reproductive guidance and genetic counseling. |
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| Keywords: Mosaicism in fetus, Parental translocation, Reciprocal translocation, Recurrent miscarriages |
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Full-Text [PDF 1150 kb]
(553 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2021/07/11 | Accepted: 2021/05/31 | Published: 2021/05/31
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