Volume 14, Issue 1 (Winter 2024)
aumj 2024, 14(1): 82-91 |
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Ethics code: IR.ABZUMS.REC.1402.133
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Sharifian zade M, Khalili A, Zibaei M, Miahipour A. Assessment of the Cannabidiol on the Lethality of Protoscolexes of Hydatid Cyst. aumj 2024; 14 (1) :82-91
URL: http://aums.abzums.ac.ir/article-1-1805-en.html
URL: http://aums.abzums.ac.ir/article-1-1805-en.html
1- Department of Medical Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
2- Department of Physiology, Pharmacology and Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
3- Department of Medical Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran ,amiahipour@yahoo.com
2- Department of Physiology, Pharmacology and Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
3- Department of Medical Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran ,
Abstract: (246 Views)
Background and Objective: Hydatid cysts are significant zoonotic diseases, with surgical intervention being the most effective treatment, particularly for large cysts located in critical areas such as the brain or heart. However, the use of chemical scolicidal agents to prevent protoscolex leakage during surgery has been limited due to their adverse side effects. Consequently, there is increasing interest in exploring new antimicrobial compounds, particularly from plants, as promising alternatives. This study aimed to investigate the lethal effects of cannabidiol, a well-known cannabinoid derived from the cannabis plant, on hydatid cyst protoscolexes.
Methods: Protoscoleces were extracted from the livers of animals infected with hydatid cysts and subsequently exposed to various concentrations of cannabidiol (1, 5, and 10 μg/ml) for 10, 30, 60, and 120 minutes. The viability of the protoscoleces was assessed using 0.1% eosin staining, with albendazole serving as a standard control for comparison.
Results: Cannabidiol exhibited significant scolicidal activity across all tested concentrations, demonstrating a direct relationship between concentration and effectiveness. While albendazole produced a scolicidal effect of 30.82 ± 0.5% after two hours, cannabidiol at concentrations of 5 and 10 μg/ml achieved scolicidal effects of 42.52 ± 0.2% and 51.04 ± 0.44%, respectively.
Conclusion: This study demonstrates that cannabidiol effectively induces significant destruction of protoscolexes, with efficacy positively correlated to concentration. These findings suggest that cannabidiol could be a valuable candidate for further research as a potential therapeutic agent in the management of hydatid cysts, warranting additional studies to explore its applicability in clinical settings.
Methods: Protoscoleces were extracted from the livers of animals infected with hydatid cysts and subsequently exposed to various concentrations of cannabidiol (1, 5, and 10 μg/ml) for 10, 30, 60, and 120 minutes. The viability of the protoscoleces was assessed using 0.1% eosin staining, with albendazole serving as a standard control for comparison.
Results: Cannabidiol exhibited significant scolicidal activity across all tested concentrations, demonstrating a direct relationship between concentration and effectiveness. While albendazole produced a scolicidal effect of 30.82 ± 0.5% after two hours, cannabidiol at concentrations of 5 and 10 μg/ml achieved scolicidal effects of 42.52 ± 0.2% and 51.04 ± 0.44%, respectively.
Conclusion: This study demonstrates that cannabidiol effectively induces significant destruction of protoscolexes, with efficacy positively correlated to concentration. These findings suggest that cannabidiol could be a valuable candidate for further research as a potential therapeutic agent in the management of hydatid cysts, warranting additional studies to explore its applicability in clinical settings.
Type of Study: Research |
Subject:
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Received: 2024/04/14 | Accepted: 2024/08/14 | Published: 2024/12/30
Received: 2024/04/14 | Accepted: 2024/08/14 | Published: 2024/12/30
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