Alborz University

Background: Thioacetamide causes disorder of lipid function . The present study was done to evaluate the protect effects omega3 fish oil supplements on disorder of lipid function induced by thioacetamide in male rats.           

Material and Methods: 42 male rats were divided into 6 groups: Control group, Sham group . Animals of this group received 0/4ml olive oil as a solvent omega3 fish oil supplements orally per day for 3 months. Thioacetamide group. Animals of this group received150 mg/kg of TAA intraperitonealy in a single dose for 3 months. Experimental groups 1,2 and 3. Animals of this groups received 100,200 and 300 mg/kg of omega3 fish oil supplements orally per day for 3 months and 150 mg/kg of TAA intraperitonealy in a single dose for 3months. All animals bled after 3 months. The provided blood samples were tested for total cholesterol, LDL and HDL cholesterol, triglyceride and glucose serum levels by enzymatic methods.            

Results: Pretreatment with 300 mg/kg of omega3 fish oil supplements significant reduced the serum level of total cholesterol comparing with thioacetamide group. Pretreatment with the omega3 fish oil supplements all doses increased the serum level of glucose comparing with thioacetamide group but there was no significant difference. Pretreatment with the omega3 fish oil supplements at all doses showed no significant difference in serum levels of LDL, HDL cholesterol and triglyceride comparing with thioacetamide group.

Conclusion: Therefore, the result show that the protective effects of omega3 fish oil supplements on disorder of lipid function induced by thioacetamide in male rats. The protective effects of omega3 fish oil supplements can be due to their antioxidant effects.