The Role of Vitamin D in Multiple Sclerosis: An Interaction Between Genes and Environment

Jalehjoo, N.; Movahedian-Attar, A.

doi:10.18869/acadpub.aums.3.2.65

Volume 3, Issue 2 (4-2014) aumj 2014, 3(2): 65-76 | Back to browse issues page

‎ 10.18869/acadpub.aums.3.2.65

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Jalehjoo N, Movahedian-Attar A. The Role of Vitamin D in Multiple Sclerosis: An Interaction Between Genes and Environment. aumj 2014; 3 (2) :65-76
URL: http://aums.abzums.ac.ir/article-1-193-en.html

The Role of Vitamin D in Multiple Sclerosis: An Interaction Between Genes and Environment

N. Jalehjoo¹

, A. Movahedian-Attar ^*²

1- Department of Clinical Biochemistry, Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2- Department of Clinical Biochemistry, Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran , movahedian@pharm.mui.ac.ir

Abstract: (5124 Views)

Multiple sclerosis (MS) is a neurodegenerative chronic inﬂammatory disease with neurological and cognitive manifestations which involves the central nervous system. The etiology of it is unknown, however, it appears several factors like genetic factors, environmental factors and their interactions play key roles in the development of MS. Many studies show that vitamin D deficiency is a risk factor for MS disease. In the 21st century, about 1 billion people worldwide are vitamin D deficient. In this article, mechanisms which are associated with protective roles of vitamin D in MS based on epidemiological, immunological, experimental, molecular and clinical studies are discussed.

Keywords: Multiple Sclerosis, Vitamin D, Genetic, Environment

Full-Text [PDF 550 kb] (2538 Downloads)

Type of Study: Research | Subject: Special
Received: 2014/08/23 | Accepted: 2014/08/23 | Published: 2014/08/23