Volume 12, Issue 3 (Summer 2023)
aumj 2023, 12(3): 341-353 |
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Lalvand M, Hashemi Hazaveh J, Bayat M. Investigating Terbinafine in the Treatment of dermatophytosis created in Indian pigs and comparing it with the amount of efficient terbinafine in the commercial drug. aumj 2023; 12 (3) :341-353
URL: http://aums.abzums.ac.ir/article-1-1752-en.html
URL: http://aums.abzums.ac.ir/article-1-1752-en.html
1- PhD student in Veterinary Medicine, Department of Basic Sciences, Faculty of Veterinary Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran
2- ssociate Professor of Veter-inary Medicine, Department of Pathobiology Sciences, Faculty of Veterinary Scien-ces, Islamic Azad University, Science and Research Bran-ch, Tehran, Iran
3- Professor of Veterinary Medicine, Department of Pathobiology Sciences, Fac-ulty of Veterinary Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran
2- ssociate Professor of Veter-inary Medicine, Department of Pathobiology Sciences, Faculty of Veterinary Scien-ces, Islamic Azad University, Science and Research Bran-ch, Tehran, Iran
3- Professor of Veterinary Medicine, Department of Pathobiology Sciences, Fac-ulty of Veterinary Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran
Abstract: (705 Views)
Introduction: In general, animals are an important source of alopecia for humans, both in urban and rural areas. Therefore, the issue of controlling dermatophytosis in animals is important for public health. The presence of infected epidermal shells in public places can be a potential source of infection. Given the high prevalence of dermatophytosis and considering the treatment of problems in some forms of the disease and the side effects of antifungal drugs, the need for appropriate replacement with current drugs seems essential.
Materials and Methods: Standard Trichophyton mentagrophytes ATCC18748 isolate and clinical isolates of Trichophyton mentagrophytes were used in the present study. 1% terbinafine in nano-form of terbinafine). Inoculation in guinea pigs was performed by the method described by Tagami et al. The site of daily lesion was followed for 20 days in terms of clinical symptoms.
Results: In studies performed on lesion score average in the nano-form group, terbinafine was combined on the first day of treatment, showing a score of 3 (significant redness with large crust). And for the normal form of the drug terbinafine (group 4) shows the number 4 (ulcers and scars along with those in grade 3), the process of reducing the degree of lesions in the treatment groups of nano-drugs, occurred between 10 and 15 days. Which is accompanied by an increase in the next 5 days. And continued with a logical process until the 40th day. On day 40, all groups had a zero score except for positive control.
Conclusion: This study shows that nano-drugs are suitable for the treatment of dermatophytosis caused by Trichophyton mentagrophytes and in terms of the effectiveness of treatment with the usual form of drugs have a more comparable intensity and speed of recovery.
Materials and Methods: Standard Trichophyton mentagrophytes ATCC18748 isolate and clinical isolates of Trichophyton mentagrophytes were used in the present study. 1% terbinafine in nano-form of terbinafine). Inoculation in guinea pigs was performed by the method described by Tagami et al. The site of daily lesion was followed for 20 days in terms of clinical symptoms.
Results: In studies performed on lesion score average in the nano-form group, terbinafine was combined on the first day of treatment, showing a score of 3 (significant redness with large crust). And for the normal form of the drug terbinafine (group 4) shows the number 4 (ulcers and scars along with those in grade 3), the process of reducing the degree of lesions in the treatment groups of nano-drugs, occurred between 10 and 15 days. Which is accompanied by an increase in the next 5 days. And continued with a logical process until the 40th day. On day 40, all groups had a zero score except for positive control.
Conclusion: This study shows that nano-drugs are suitable for the treatment of dermatophytosis caused by Trichophyton mentagrophytes and in terms of the effectiveness of treatment with the usual form of drugs have a more comparable intensity and speed of recovery.
Type of Study: Research |
Subject:
Special
Received: 2022/10/06 | Accepted: 2023/03/13 | Published: 2023/09/01
Received: 2022/10/06 | Accepted: 2023/03/13 | Published: 2023/09/01
References
1. Abad MJ, Bedoya LM, Apaza L, Bermejo P. The Artemisia L. genus: a review of bioactive essential oils. Molecules 2012;17(3): 2542-66. [DOI:10.3390/molecules17032542]
2. Machado GAC. Dermatopatias diagnosticadas em cães no hospital de medicina veterinária da Universidade Federal da Bahia por avaliações histopatológicas (2007-2016) e clínico-laboratoriais (2015-2017). 2017.
3. Jungerman PF, Schwartzman RM. Veterinary medical mycology1972.
4. John H, David A. Reference method for broth dilution antifungal susceptibility testing of yeast fungi. Approved standard second edition (formerly NCCLS m27A2), Clinical and Laboratory Standards Institute, Pennsylvania, USA 2008;16.
5. Knoll MA, Ulmer H, Lass-Flörl C. Rapid Antifungal Susceptibility Testing of Yeasts and Molds by MALDI-TOF MS: A Systematic Review and Meta-Analysis. Journal of Fungi 2021;7(1): 63. [DOI:10.3390/jof7010063]
6. Muller G, Kirk R, Scott D, et al. Immune-mediated disorders. Muller & Kirk's Small Animal Dermatology, 6th ed WB Saunders Co, Philadelphia, Pennsylvania 2001: 667-779. [DOI:10.1016/B978-0-7216-7618-0.50013-4]
7. Scott DW, Miller Jr WH, Griffin CE. Dermatoses of pet rodents, rabbits, and ferrets. Muller & Kirk's Small Animal Dermatology 2001: 1415. [DOI:10.1016/B978-0-7216-7618-0.50025-0]
8. Daar J, Khan A, Khan J, et al. Studies on self-nanoemulsifying drug delivery system of flurbiprofen employing long, medium and short chain triglycerides. Pak J Pharm Sci 2017;30(2): 601-6.
9. Atan NAD, Koushki M, Motedayen M, et al. Type 2 diabetes mellitus and non-alcoholic fatty liver disease: a systematic review and meta-analysis. Gastroenterology and hepatology from bed to bench 2017;10(Suppl1): S1.
10. Shimamura T, Kubota N, Shibuya K. Animal model of dermatophytosis. Journal of Biomedicine and Biotechnology 2012;2012. [DOI:10.1155/2012/125384]
11. Siripatrawan U, Harte BR. Physical properties and antioxidant activity of an active film from chitosan incorporated with green tea extract. Food hydrocolloids 2010;24(8): 770-5. [DOI:10.1016/j.foodhyd.2010.04.003]
12. Chen W, Vermaak I, Viljoen A. Camphor-a fumigant during the black death and a coveted fragrant wood in ancient Egypt and Babylon-a review. Molecules 2013;18(5): 5434-54. [DOI:10.3390/molecules18055434]
13. Dash M, Chiellini F, Ottenbrite RM, Chiellini E. Chitosan-A versatile semi-synthetic polymer in biomedical applications. Progress in polymer science 2011;36(8): 981-1014. [DOI:10.1016/j.progpolymsci.2011.02.001]
14. Kong M, Chen XG, Xing K, Park HJ. Antimicrobial properties of chitosan and mode of action: a state of the art review. International journal of food microbiology 2010;144(1): 51-63. [DOI:10.1016/j.ijfoodmicro.2010.09.012]
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