Volume 12, Issue 3 (Summer 2023)
aumj 2023, 12(3): 341-353 |
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Lalvand M, Hashemi Hazaveh J, Bayat M. Investigating Terbinafine in the Treatment of dermatophytosis created in Indian pigs and comparing it with the amount of efficient terbinafine in the commercial drug. aumj 2023; 12 (3) :341-353
URL: http://aums.abzums.ac.ir/article-1-1752-en.html
URL: http://aums.abzums.ac.ir/article-1-1752-en.html
1- PhD student in Veterinary Medicine, Department of Basic Sciences, Faculty of Veterinary Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran
2- ssociate Professor of Veter-inary Medicine, Department of Pathobiology Sciences, Faculty of Veterinary Scien-ces, Islamic Azad University, Science and Research Bran-ch, Tehran, Iran
3- Professor of Veterinary Medicine, Department of Pathobiology Sciences, Fac-ulty of Veterinary Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran
2- ssociate Professor of Veter-inary Medicine, Department of Pathobiology Sciences, Faculty of Veterinary Scien-ces, Islamic Azad University, Science and Research Bran-ch, Tehran, Iran
3- Professor of Veterinary Medicine, Department of Pathobiology Sciences, Fac-ulty of Veterinary Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran
Abstract: (704 Views)
Introduction: In general, animals are an important source of alopecia for humans, both in urban and rural areas. Therefore, the issue of controlling dermatophytosis in animals is important for public health. The presence of infected epidermal shells in public places can be a potential source of infection. Given the high prevalence of dermatophytosis and considering the treatment of problems in some forms of the disease and the side effects of antifungal drugs, the need for appropriate replacement with current drugs seems essential.
Materials and Methods: Standard Trichophyton mentagrophytes ATCC18748 isolate and clinical isolates of Trichophyton mentagrophytes were used in the present study. 1% terbinafine in nano-form of terbinafine). Inoculation in guinea pigs was performed by the method described by Tagami et al. The site of daily lesion was followed for 20 days in terms of clinical symptoms.
Results: In studies performed on lesion score average in the nano-form group, terbinafine was combined on the first day of treatment, showing a score of 3 (significant redness with large crust). And for the normal form of the drug terbinafine (group 4) shows the number 4 (ulcers and scars along with those in grade 3), the process of reducing the degree of lesions in the treatment groups of nano-drugs, occurred between 10 and 15 days. Which is accompanied by an increase in the next 5 days. And continued with a logical process until the 40th day. On day 40, all groups had a zero score except for positive control.
Conclusion: This study shows that nano-drugs are suitable for the treatment of dermatophytosis caused by Trichophyton mentagrophytes and in terms of the effectiveness of treatment with the usual form of drugs have a more comparable intensity and speed of recovery.
Materials and Methods: Standard Trichophyton mentagrophytes ATCC18748 isolate and clinical isolates of Trichophyton mentagrophytes were used in the present study. 1% terbinafine in nano-form of terbinafine). Inoculation in guinea pigs was performed by the method described by Tagami et al. The site of daily lesion was followed for 20 days in terms of clinical symptoms.
Results: In studies performed on lesion score average in the nano-form group, terbinafine was combined on the first day of treatment, showing a score of 3 (significant redness with large crust). And for the normal form of the drug terbinafine (group 4) shows the number 4 (ulcers and scars along with those in grade 3), the process of reducing the degree of lesions in the treatment groups of nano-drugs, occurred between 10 and 15 days. Which is accompanied by an increase in the next 5 days. And continued with a logical process until the 40th day. On day 40, all groups had a zero score except for positive control.
Conclusion: This study shows that nano-drugs are suitable for the treatment of dermatophytosis caused by Trichophyton mentagrophytes and in terms of the effectiveness of treatment with the usual form of drugs have a more comparable intensity and speed of recovery.
Type of Study: Research |
Subject:
Special
Received: 2022/10/06 | Accepted: 2023/03/13 | Published: 2023/09/01
Received: 2022/10/06 | Accepted: 2023/03/13 | Published: 2023/09/01
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