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Cerebral Cortex Thickness in Patients with Temporal Lobe Epilepsy Using Magnetic Resonance Imaging
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Iman Sarbisheh1    , Leili Tapak * 2, Alireza Fallahi3 , Javad Fardmal4 , Majid Sadeghifar5 , Mohammad Reza Nazemzadeh6 , Jafar Mehvari Habibabadi7 |
1- Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Biostatistics, School of Public Health and Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Hamedan University of Technology, Hamadan, Iran
4- Department of Biostatistics, School of Public Health and Modeling of Noncommunicable Diseases Research Center,, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Statistics, Faculty of Sciences, Bu-Ali Sina University, Hamadan, Iran
6- Research Center for Molecular and Cellular Imaging, Advanced Medical Technologies and Instruments Institute (AMTII), Tehran University of Medical Sciences, Tehran, Iran
7- Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran |
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Abstract: (1026 Views) |
Background: Abnormalities in the structure of the cerebral cortex of patients with temporal lobe epilepsy can be detected by magnetic resonance imaging (MRI). However, many of these patients have a normal MRI even a few years after the disease. The aim of this study was to evaluate and compare the cortical thickness of patients with left and right temporal lobe epilepsy with healthy individuals using MRI images.
Methods: In the present study, MRI images of healthy control cases (n = 20) and patients with left temporal lobe epilepsy (n = 19) and right temporal lobe epilepsy (n = 14) were used. The mean cortical thickness of these patients was calculated using FREESURFER software. Finally, areas of the cerebral cortex affected by epilepsy were identified and introduced by Mann-Whitney U test.
Results: Patients with left temporal lobe epilepsy had less cortical thickness than healthy individuals in the cingulate, anterior, occipital, and parietal lobes. Cortical thickness atrophy was seen in patients with right lobe epilepsy compared to healthy control individuals in the right hemisphere in the occipital lobe in the lateral occipital region. There was no significant difference between the mean cortical thickness in patients with right and left temporal lobe epilepsy.
Conclusion: In the present study, changes and disturbances in the thickness of gray matter in different areas of the cerebral cortex of patients with temporal lobe epilepsy have been identified as the effects of this disease on the cerebral cortex.
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| Keywords: Cortical thickness, Magnetic resonance imaging, Temporal lobe epilepsy, False discovery rate |
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Full-Text [PDF 365 kb]
(784 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2022/07/31 | Accepted: 2022/08/01 | Published: 2022/08/01
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