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Assessment of Maternal Vitamin D and CRP Plasma Levels Correlation to Preeclampsia and Its Severity: Case Control Study
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Bita Badehnoosh1    , Ramin Tajbakhsh2 , Kourosh Kabir3 , Kiarash Azadi * 4 |
1- Department of Obstetrics & Gynecology, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran
2- Department of Internal Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
3- Department of Statistics and Epidemiology, Alborz University of Medical Sciences, Karaj, Iran
4- Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran , kiarash.ai.20@gmail.com |
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Abstract: (1424 Views) |
Introduction:Preeclampsia is a serious, inflammatory-mediated hypertensive disorder of pregnancy affecting approximately 8% of all pregnancies. Based on recent studies, women with vitamin D deficiency may have an increased risk of developing preeclampsia. The aim of the study was to evaluate the vitamin D and CRP levels and explore the role and correlation between each other and also occurrence of preeclampsia.
Material and methods:55 preeclamptic women and 55 healthy pregnant women were selected from Kamali hospital in karaj, Iran. 6 ml of venous blood sample was collected from each pregnant woman and the serum 25-OH-D and CRP levels were measured by ELISA which reported in ng/mL and mg/dL, respectively. Data were analyzed by independent t-test, Mann-Whitney U test, Chi square and logistic regression.
Results:Preeclamptic women (n=55) were noted to have decreased total 25-OH-D and elevated CRP levels relative to healthy control women (n=55; P<0.001). This difference in vitamin D deficiency remained significant after adjustment for maternal age and BMI [odds ratio (OR) = 12.54, confidence interval (CI) = 1.03–154.95, P=0.047].
Conclusion: These results showed that vitamin D deficiency and abnormal inflammatory status have a statistically significant relationship with preeclampsia and support the hypothesis that vitamin D deficiency may be a risk factor for preeclampsia in the context of an inflammatory condition. |
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| Keywords: Vitamin D, Pregnancy, Preeclampsia, C-reactive protein |
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Full-Text [PDF 1469 kb]
(617 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2021/07/12 | Accepted: 2021/05/31 | Published: 2021/05/31
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