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Importance of Chromosomal Studies in Cell Therapy and Its Applications
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Fatemeh Mansouri    , Ali Golchin |
| Department of Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran , ansouri1600@hotmail.com |
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Abstract: (1030 Views) |
Currently, the use of cell therapy is an effective treatment method in some types of diseases. The use of stem cells and somatic cells, due to the complete genetic similarity with individual cells, has led to the development of cell therapy methods. In recent years, significant advances have been made in the methods of culturing, isolating, and long-term cell maintenance. However, there are still problems and concerns related to their clinical use, the resolution of which requires more detailed studies in this area. One of these problems is genomic changes in cells that can affect the potential for differentiation of stem cells. Genetic abnormalities occur during successive cultures during the process of proliferation and differentiation, and can affect cell behavior and subsequent laboratory results. The aim of this study is to investigate the importance of chromosomal studies in cell therapy for the analysis of chromosomes and summarize the applications and limitations of these methods in the medical sciences.
Conclusion: The results of this discussion show that the use of different techniques of chromosomal studies can be considered in the final evaluation and obtaining confirmation of the accuracy of cellular products in treatment. Periodic and regular examinations of genomic stability in cells before their clinical use are essential. |
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| Keywords: Stem cells, Chromosome, Cell therapy, Genetic abnormalities |
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Full-Text [PDF 1719 kb]
(423 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2021/10/16 | Accepted: 2021/10/02 | Published: 2021/10/02
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