Alborz University of Medical sciences Alborz University Medical Journal 2322-3839 1 2 2012 3 1 Knowledge, Attitude and Behaviors of People Referred to Health Centers of Tehran About Iranian Traditional Medicine 65 70 FA N. Zafarghandi Obstetrician & Gynecologist , Shahed University, Tehran, Iran A. Pirasteh Health & Social Medicine Department, School of Medicine, Shahed University, Tehran, Iran K. Khajavi Health & Social Medicine Department, School of Medicine, Shahed University, Tehran, Iran F.S. Bateni MD, School of Medicine, Shahed University, Tehran, Iran Background: Traditional medicine in Iran with the long and old background from ancient period until now has very beneficial practical and technical experience. At present despite development of conventional medicine, many patients refer to traditional medicine. This study aimed to investigate knowledge, practice and attitude toward Iranian Traditional Medicine. Methods: This study is cross-sectional and the sample of the study was 350 persons who refer to health centers of Tehran (older than 15 year). Our data was collected via standard questionnaire. Results: Mean age of participant was 34.1 SD 1.21 and 60.9% were women. Their knowledge about Iranian traditional medicine was 26.3% and 69% of them has used at least one of the traditional medicine methods that the most of them were herbal therapy(70.1%) and Hejamat(44%).generally the attitude was positive and (37%)had extremely positive and (57.6%)positive attitude toward traditional Iranian Medicine. Conclusion: In light of this result it is clear that Iranian people have a positive tendency toward Iranian Traditional medicine, so the best and complete researches for better planning is recommended.

Alborz University of Medical sciences Alborz University Medical Journal 2322-3839 1 2 2012 3 1 Epidemiological Study of Poisoning in Teaching Hospitals in Shiraz in 1387 71 76 FA M. Aryaie Department of Epidemiology, School of Public Health Tehran University of Medical Sciences, Tehran, Iran R. Dokoohaki Faculty Mentor Nursing and Midwifery, Shiraz University of Medical Sciences A. Rezaeian Mehrabadi Department of Toxicology, School of Pharmacy, Shiraz University of Medical Sciences F. Bakhsha Department of Anesthesiology, School of Paramedical, Golestan University of Medical Sciences, Gorgan, Iran Background/Objective: Poisoning is One common cause of referred cases , especially in the adolescent and young group to hospital emergency department. This study was designed to determine Epidemiologic of poisoning in teaching hospitals, shiraz in 1387 Methods: This is a cross-sectional study that 266 sample via random sampling with 95% confidence interval and α 0.05 were considered. Results: There were 47% female and 53% male. 67.2 percent of poisoned patient were single and 32.8% were married. This study showed, highest rate of poisoning was between the age of 20-35 years. Most common season of poisoning was in spring. Overall mortality of our study was 1.6 percent. Conclusions: Regional epidemiological information, make rational use of resources in order to prevention and control of poisoning and with using analysis of effective factors will be reduced poisoning by policymakers and planners.

Alborz University of Medical sciences Alborz University Medical Journal 2322-3839 1 2 2012 3 1 Evaluation of Inhibitory Effects of Berberine on Apoptosis Due to Measles Virus Strain AIK-HDC 77 84 FA K. Haratian Department of Pathobiology, Alborz University of Medical Sciences, Karaj, Iran A. Mohseni Meybodi Department of Genetics, Reproduction Biomedicine Research Center, Royan Institute for Reproduction Biomedicine, ACECR, Tehran, Iran Background: Measles virus (MV) is a highly contagious agent which causes a major health problem in developing countries. We studied the effect of BERBERINE on the replication of an AIK-HDC strain of MV and its induced apoptosis in Vero cell lines. Methods: In this study, toxicity of BERBERINE on Vero cells was investigated first, resulted in determination of sub-lethal or non-toxic concentration zone of BERBERINE for cells. Next, anti-viral effect of BERBERINE at various time limits was evaluated and virus titer was determined at each stage either as 50% tissue culture infective dose TCID50 or by plaque assay method. Using specific anti-measles IgG, anti-viral effect of BERBERINE on MV replication cycle was evaluated through indirect immunofluorescence assay, meanwhile presence of viral RNA was investigated by RT-PCR and gel- electrophoresis. Results: According to the experiments, BERBERINE, at concentration of 50 μM, markedly inhibited the cytopathic effect (CPE) induced by MV. BERBERINE also significantly inhibited apoptosis induced by MV. BERBERINE either influences replication of MV genome, or may inhibit virion formation. Conclusion: These results suggest that the inhibition of CPE and apoptosis by BERBERINE induced by MV may be associated with the effect of BERBERINE on viral RNA genome. Therefore, it is suggested that MV infections can induce apoptosis through the activation of a common pathway that can be blocked by BERBERINE or some of its ingredients.

Alborz University of Medical sciences Alborz University Medical Journal 2322-3839 1 2 2012 3 1 Application of the Transtheoretical Model to Predict Exercise Activities in the Students of Islamic Azad University of Sabzevar 85 92 FA M. Mohammadi Department of Health Education, School of Health, Yazd University of Medical Sciences, Iran A. Mehri Department of Health Education. School of Health, Tehran University of Medical Sciences and Lecturer Background: Based on report of World Health Organization (WHO), about 60-85% of the world's population fails to complete the recommended amount of physical activity required to induce health benefits. It is necessary to assess health status for designing and programming about exercise activities. In this study the effectiveness of Transtheoretical Model (TTM) in predicting exercise activities among the students of Islmaic Azad University of Sabzevar was examined. Methods: In this cross sectional-Correlational study. A random (clustered) sample of 234 university students in Islamic Azad university of Sabzevar, participated in the study. A standard instrument was used to measure the variables of interest based on transtheoretical model. Reliability and validity of the questionnaire was examined by a panel of experts and cronbach alpha (N=30, α=0.83-0.95). The data were analyzed by SPSS 16.00 statistical software using Path analysis based regression, t-test and ANOVA and Correlation. Results: According to the results, the average age of students was 22.5±3.8 years. The distribution of the participants according to the stages of change model was as follows: pre-contemplation 36.3%, contemplation 25.6%, preparation, 18.9%, action, 10.5% and maintenance 8.7%.These were significant differences between mean of self efficacy, process of change, decisional balance by sex (p<0.05) and stages of change (p<0.01). Behavioral process of change (β=0.399) and self efficacy (β=0.350) were the most important variables for improving levels of exercise. Conclusion: Because the most students (62%) were at precontemplation, contemplation and preparation stages and the results showed that behavioral process of change perceived barriers and self efficacy are the most important predictors for improving levels of exercise. Thus, policies and programs to strengthen these factors to promote exercise activities among students is recommended.

Alborz University of Medical sciences Alborz University Medical Journal 2322-3839 1 2 2012 3 1 Reviewing Sexual Function After Delivery and Its Association with Some of the Demographic Marital Satisfaction Factors 93 99 FA Kh. Broumandfar Department of Social Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Z. Farajzadegan Department of Social Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran H. Hoseini Department of Nursing Health, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran M. Ghaed Rahmati Department of Nursing Health, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran Background: Desirable sexual function has an important role in strengthening the marital life of the couples. Sexual disorders can cause mental pressure and affect quality of life and marital relationship. Methods: This was a descriptive correlation study in one group and one phase covering multivariables. The study sample included 384 women after delivery period that had the following inclusion criteria: the age of at least 18 years, delivery in 38-42 pregnancy weeks, primiparous and multiparous women, living in the city, single pregnancy, and twelve months elapsed from the delivery. The required data such demographic, marital satisfaction and sexual function index were collected through reporting questionnaire. The data were analyzed using descriptive and inferential statistical methods using software SPSS. Results: The findings of the study indicated that the most prevalent disorder of the sexual relationship in postpartum was dyspareunia and the least prevalent was the sexual desire. There was no significant association between sexual function and, age, education degree , body mass index ,body size and job, but there was a significant association for other factors such as the economic, residence and marital satisfaction (p<0.01). Conclusion: It is recommended that sexual problems after delivery be placed on the list of health teaching issues to pass easily this period of time. Women should be assured that these problems gradually would be improved and they should learn using proper techniques to decrease dyspareunia which is a sexual disorder in postpartum period.

Alborz University of Medical sciences Alborz University Medical Journal 2322-3839 1 2 2012 3 1 Assessment of Medical Science Students‘ Knowledge Regarding the Role of Nutrition in Prevention or Incidence of Cancer in Tabriz University 100 108 FA L. Payahoo Department of Food Science, Faculty of Health and Nutrition. Tabriz University of Medical Sciences B. Alipoor Department of Food Science, Faculty of Health and Nutrition. Tabriz University of Medical Sciences J. Baghdadchi Department of Food Science, Faculty of Health and Nutrition. Tabriz University of Medical Sciences Background: Cancer is chronic disease that its prevalence is growing in recent years. Genetics and environmental factors such as energy balance and nutritional habits are involved in its incidence. The nutrition plays an important role in prevention and incidence of cancer due to protective and harmful factors, respectively. The aim of this study was to assess the knowledge of medical sciences students regarding the role of nutrition in prevention or incidence of cancer in Tabriz University. Methods: This Cross- sectional study conducted on 565 (219 male and 346 Female) senior students of medical sciences. A self-administered questionnaire with two part completed by students. the one was about the demographic characteristics (age, gender, course, level of education, passing nutrition unit through the school and source of nutritional information) and the other one with 22 closed and open questions was about nutritional knowledge. Data analyzed by using descriptive statistics and presented as frequency and percent. Assessment of relationship between nutritional knowledge and demographic variable were used the Pearson correlation and ANOVA. Results: About 13% of students had low level of nutritional knowledge and 41% and 45.6% had acceptable and high level of knowledge, respectively. Relationship between course, level of education, passing nutrition unit through the school and source of nutritional information of students with nutritional knowledge were statistically significant and with age and gender were no statistically significant relationship. Conclusion: Nutritional factors had important role in incidence of cancer and individual knowledge in this regard is important. In our study, medical knowledge of students, as future provider of health information hadn´t adequate level, so using of efficient co-educational materials for increasing their knowledge may be beneficial.

Alborz University of Medical sciences Alborz University Medical Journal 2322-3839 1 2 2012 3 1 Induction of Apoptosis in K562 Leukemia Cells Upon Exposure to a Derivative from 4-aryl-4H Chromenes Family 109 116 FA M.H. Naseri Alborz University of Medical Sciences, Karaj, Iran S. Hesami Tackallou Department of Biology, Islamic Azad University, Garmsar Branch, Garmsar, Iran M. Mahdavi Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran M.A. Moosavi Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran S. Abasalti Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran A. Foroumadi Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran A. Hadizade Baqiyatallah, University of Medical Sciences, Tehran, Iran Objective: It has been recently reported the activity of 4-aryl-4H-chromenes family to induce apoptosis in human cancer cells. Herein we report a derivative of 4-aryl-4H-chromene compound with higher apoptotic activity against Chronic Myelogenous Leukemia K562. The cells were seeded in 24-well plates at 1×105 cells/well and treated with 5-30 nM of the 2-amino-4-(3-bromo 4,5 dimethoxy-phenyl) -3-cyano -7-(dimethylamino) -4H-chromene (3-BMPC). This compound was found to be highly active growth inhibitor with IC50 of 10±3.1 nM as determined by MTT assay. Proliferation of K562 cells was diminished by more than 80% and viability was decreased by about 50% upon 96 h of treatment with 30 nM concentration of the compound. Apoptosis as the mechanism of cell death was investigated morphologically by Hoechst 33258 staining, as well as the formation of DNA ladder. K562 cells underwent apoptosis upon a single dose (at IC50 value) of the compound. These data further suggest that 3-BMPC may provide a novel therapeutic approach for the treatment of leukemia.

Alborz University of Medical sciences Alborz University Medical Journal 2322-3839 1 2 2012 3 1 Study of Effectiveness of Human Factors Engineering Interference in Cumulative Trauma Disorders Rate Decreasing in the Tehran South Health Center 2005-2006 117 122 FA M. Noorisepehr Alborz University of Medical Sciences, Karaj, Iran J. Rahimi Hamedan University of Medical Sciences M.B. Delkhosh Semnam University of Medical Sciences A. Kabolizadeh Alborz University of Medical Sciences, Karaj, Iran R. Golmohammadi Hamedan University of Medical Sciences Introduction: Up to now accomplished many investigations about cumulative trauma disorders (CTD) accession. For the most part sitting pattern and unsuitable task posture has been specified reason of these complications. In the publicized stats from a foreign source ambit of 44 percent of people who worked with computer has been afflict to the CTD's. The aim of this paper is to find and measurement of CTD and ergonomic intervention and investigation rate of this intervention's effect in the Tehran south health center. This center use paperless system. Methods: In this research Nordic questionnaire distribute between 68 persons of the center to determine CTD's. By technical expert inspection specified reason of complications. Observantly to state methods reason which create more severity and frequency CTD's has been recognized and interference with human factors engineering. For the more efficiency of interference Anthropometry has been used for all of Work stations and for any person designed a significant posture. Results: results that obtained before interference indicate that were CTD's complications at more of employees which 90 percent of them suffered of up spine pain. Also 27.4 percent of them had shoulder pain and 20.4 percent had neck pain. After the interference these measures decreased. And complaint of employee decreased 40.8 percent to up spine pain. Also for the shoulder pain it reached to 22 and neck pain 17.6 percent. With state test identified that there are significant difference between CTD after and before of intervention (p<0.005). Conclusion: Being unsuitable task posture is main cause of CTD's in the Work stations. We can prevent to increasing these complications in the work place by simple approach like adjustment in the desk and chair height, correct performance working training and doing simple exercise.