@article{ author = {Sheibani, Mohamad and Azarsina, Salman and Najafi, Arvin and Mirhoseini, Mohammad Sajjad and SeyyedGhasemi, Elham al-Sadat and Rastgo, Mohadese and Khani, Yosef}, title = {Investigating the average duration between hospitalization and surgery and discharge of orthopedic patients with peritrochanteric fracture in patients over 60 years old in Shahid Madani Hospital in 2022}, abstract ={Background and objectives: Usually, patients with femur fractures, including peritrochanteric fractures, have associated comorbidities, which increase the duration of hospitalization, increase the rate of complications, and increase mortality. The aim of this study was to determine the average time between hospitalization and surgery and discharge of patients over 60 years old with peritrochanteric fracture in Shahid Madani Hospital in 2022. Materials and methods: The current study is a cross-sectional study. Demographic information, underlying diseases, BMI, length of time between hospitalization and surgery, surgery and discharge, and hospitalization and discharge were collected. The relationship between prognostic factors and length of hospitalization was investigated and the significance level of p value was less than 0. 05 was considered. Findings: A total of 250 patients (114 women and 136 men) with an average age of 75.6 ± 98 years were included in the study. The average time between hospitalization and surgery was 60.7 ± 23.8 hours, and the time between surgery and discharge was 24. 63.3 ± 4 hours and the time between hospitalization and discharge was 124.1 ± 35.9 hours. In female gender, age over 75 years and suffering from diabetes, cardiovascular disease, hypertension and respiratory disease, the time between hospitalization and Surgery was significantly higher. In female gender, age over 75 years, increased BMI, diabetes and respiratory disease, the duration between surgery and discharge was significantly higher. In general, increasing the length of time between hospitalization and discharge was significantly related to female gender, age over 75 years, increased BMI and diabetes, cardiovascular disease, hypertension, and respiratory disease. Conclusion: Conducting this study led to the identification of risk factors that can be adjusted in patients, so that by reducing the complications of fracture and surgery, as well as reducing the duration of hospitalization, the chances of recovery and faster return to daily life can be increased.}, Keywords = {Peritrochanteric fracture, Prognosis, Hospitalization period}, volume = {13}, Number = {0}, pages = {1-8}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.1}, url = {http://aums.abzums.ac.ir/article-1-1787-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1787-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Azarsina, Salman and Najafi, Arvin and Mirhosseini, Mohammad Sajjad and Yazdani, Shahrooz and Sheibani, Mohammad and Khani, Yosef and Bahramian, Mehran and Baniamrian, Arash}, title = {Investigating factors affecting the delay in surgery and the increase in one-month mortality of patients with proximal femur fractures in patients referred to Shahid Madani Alborz Hospital during 2020-2021}, abstract ={Introduction and goal: With the aging of the population, hip fracture in the elderly has become a growing medical and social concern. Whether early surgery is beneficial in such patients is a long-standing debate and a constant clinical concern in the management of patients with hip fracture. Is What seeming necessary is to review the guidelines on how to deal with such patients in different health care systems. Therefore, this study was conducted with the aim of investigating factors affecting the delay in surgery and the increase in one-month mortality of patients with proximal femur fractures in patients referred to Shahid Madani Alborz Hospital during 2020-2021. materials and methods: This cross-sectional analytical study was conducted on 126 patients in Shahid Madani Hospital in Karaj city during the years 2013-1400. Patients were divided into six groups according to the time taken until surgery (less than 24 hours to more than 120 hours). After that, the death and its cause in one month after the surgery were investigated by phone calls and examination of patients' files in the clinic. Data were collected using pre-designed forms and information recorded in patients' files, as well as using the same device and operator for each patient. findings: Among the 126 patients included in the study, 103 (81.74) were women and 13 (18.26) were men. 4 patients (2.5%) underwent urgent surgery. 17 patients (13.8%) underwent surgery within 24 hours after admission and 82 patients (64.9%) underwent surgery more than 48 hours after admission. The results showed that the mortality rate increases significantly with a delay of more than 120 hours. Lack of available operating room for planned surgery (60.3%) was the most common cause of surgical delay. Older age, dementia, and the need for assistance with activities of daily living before the fracture were also associated with higher rates of medical complications. Conclusion: In summary, our study showed that very long delays increase the patient's stay in the hospital and thus may increase the risk of mortality and some medical complications.}, Keywords = {Proximal femur fracture, delay in surgery, complications after surgery}, volume = {13}, Number = {0}, pages = {9-18}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.9}, url = {http://aums.abzums.ac.ir/article-1-1639-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1639-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Maghsoudi, Mohammadreza and Mahdavi, Fatemehsadat}, title = {Aortic aneurysm with dysphagia}, abstract ={A 66-year-old male suffering from dysphagia with progressive severity of about three months’ duration was admitted to the Emergency department. During the last week, he had drooling and hoarseness. In the past week, he described two times of syncope. And he indicated chronic cough and mild sputum recently. An incidental chest radiography showed evidence of marked dilation of the aortic arch and deviation of trachea. Echocardiography revealed LVEF of 55% and a grade 1 left ventricular diastolic dysfunction. Also, aneurysmal dilation of thoracic aortic curve containing crescentric form thrombosis with calcification mostly suggestive of thrombosis within aneurysm was seen. With 100% stenosis of LAD, Major Diagonal and RCA, he was recommended for CABG. Aneurysm of the thoracic aorta is a very rare cause of dysphagia and it must be differentiated from other causes, since proper managements can significantly reduce the morbidity and mortality of this disease. Discussion: Etiologies of esophageal dysphagia include neuromuscular disorders (such as achalasia and scleroderma), intrinsic structural lesions (like esophageal carcinoma, esophageal rings and webs and eosinophilic esophagitis) and extrinsic structural lesions (like mediastinal lesions and vascular compression).Aneurysm of the thoracic aorta is a very rare cause of dysphagia and it must be differentiated from other causes, since proper managements (like urgent surgical interventions if needed) can significantly reduce the morbidity and mortality of this disease. Treatment of dysphagia caused by aortic aneurysm can be conservative, surgical or palliative depending on the severity of the symptom. By accurate management, prognoses of the patients are almost always good. In coping with dysphagia, gastrointestinal disorders should not be the only complications that is payed attention and dysphasia must be considered as a rare sign of aneurysms. The case report on this rare cause should contribute to better diagnosis of dysphagia aortica and swallowing difficulties in general.}, Keywords = {Aortic aneurysm, dysphagia}, volume = {13}, Number = {0}, pages = {19-24}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.19}, url = {http://aums.abzums.ac.ir/article-1-1788-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1788-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {ZebarjadiBagherpour, Javad and Bahri, Mohamad Hadi and Bozorgmehr, Ramin and Ahmadinejad, Mojtaba and Sheikhi, Saman and Hajimaghsoudi, Leila and Pak, Haleh and Soltanian, Ali}, title = {Spontaneous pneumothorax caused by Covid-19; A Review Article}, abstract ={Three years after the announcement of the 2019 coronavirus disease (COVID-19) as an epidemic, the investigation of its signs and symptoms in different body systems continues. These clinical manifestations can be investigated both at the acute level and at the complication level. Within the respiratory system, the most common manifestation is pneumonia, which is often characterized bilaterally and involves the periphery of the lung, coming to the center of the lung, which is often accompanied by leukopenia and lymphopenia. Several cases of spontaneous pneumothorax have been reported in the context of Covid-19, this study aims to provide more comprehensive information by reviewing past studies that are often case reports of spontaneous pneumothorax.}, Keywords = {Covid-19, pneumothorax}, volume = {13}, Number = {0}, pages = {25-31}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.25}, url = {http://aums.abzums.ac.ir/article-1-1791-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1791-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Zanjani, Amir Poya and Rezaee, Mehdi and Samadi, Shahram and Nabavian, Omid and EmamiMeibodi, Seyed Ali and KordValeshabad, Ali}, title = {Investigating the effect of adding doses of 100 and 200 mg of tramadol as adjuvant in interscalene block by bupivacaine 0.25% on increasing the duration of analgesia after arthroscopic shoulder surgery in Imam Khomeini Hospital (RA) in Tehran during the years 2016-2017}, abstract ={Background: Anesthesiologists and surgeons strive as a team to minimize postoperative patient reported pain scores by using modern multimodal pain management protocols. This study was designed to examine the effects of adding different doses of adjuvant tramadol to bupivacaine solution in interscalene block (ISB) in patients undergoing shoulder arthroscopic surgery. Methods: In this prospective controlled randomized double-blinded trial, 60 consecutive eligible subjects candidate for arthroscopic shoulder surgery were assigned randomly into 3 groups. The patients were assigned to receive one of the specific doses of tramadol in bupivacaine mixture in their preoperative ultrasound-guided ISB. In the control group (T0), the ISB was performed with 30 ml solution of perineural 0.25% bupivacaine and epinephrine. The block was performed with the same solution mixed with 100 or 200 mg of adjuvant tramadol with a total volume of 30 ml in patient in T100 and T200 groups, respectively. The required postoperative duration of analgesia, 24 hours postoperative analgesic consumption, observational and patient-reported pain scores, and side effects were recorded in the recovery room and up to 24 hours. Results: Mean postoperative analgesia duration was significantly longer in group T200 (681 ± 270 min) than in Group T100 (501 ± 298 min) and Group T0 (402 +/- 223 min) (P =0.006). A statistically significant difference was found in the first 24 hour postoperative cumulative opioid consumption among groups T200 (5.5 +/- 3.2 mg), T100 (9.0 +/- 4.5 mg) and T0 (9.30+/- 4.78 mg) (P=0.009).  There was no intergroup difference in intraoperative analgesic consumption, postoperative sedation score, and complications due to ISB or tramadol adverse effects. Conclusion: There is a dose-dependent prolongation of ISB with adjuvant tramadol for arthroscopic shoulder surgeries.}, Keywords = {interscalene block, tramadol, shoulder arthroscopy}, volume = {13}, Number = {0}, pages = {32-42}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.32}, url = {http://aums.abzums.ac.ir/article-1-1792-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1792-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {AlizadehKashani, Reza and Hatamian, Sevak and Hamidian, Siamak and Nourian, Nazani}, title = {Diagnosis of acute pulmonary embolism with EKG changes Similar to acute coronary syndrome by bedside cardiac Ultrasound evaluation: case report and review of article}, abstract ={Introduction: Acute pulmonary embolism (PE) is an emergency and life-threatening disease that despite its relatively high prevalence in ICU patients, is still difficult to diagnose due to non-specific signs and symptoms. Symptoms such as shortness of breath and chest discomfort are completely non-specific and overlap with the diagnosis of acute coronary syndrome (ACS). Materials and methods: EKG changes associated with acute pulmonary embolism are highly variable and can resemble acute coronary syndromes. Recently, changes in precordial leads in the form of inverted T wave have been described as a diagnostic clue of PE, although these changes are also seen in acute coronary syndrome. Results: In this article, we report a 92-year-old man with dyspnea and progressive hypotension. Which was initially wrongly diagnosed as acute coronary syndrome due to diffuse inverted T in precordial leads V1 to V6, and pulmonary embolism was confirmed after cardiac ultrasound evaluation at the bedside. Conclusion: In this article, we will talk about the diagnosis of this case and the review of related texts, emphasizing the limitations of EKG and the importance of using cardiopulmonary ultrasound at the bedside.}, Keywords = {Acute pulmonary embolism, acute coronary syndrome, T wave inversion, bedside cardiopulmonary ultrasound}, volume = {13}, Number = {0}, pages = {43-48}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.43}, url = {http://aums.abzums.ac.ir/article-1-1793-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1793-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Larijani, Amirhossein and BaradaranBagheri, Ali and Maleki, Hossein and Chavoshi-nejad, Mehdi and Sarchahi, Sina and Khalaji, Narges}, title = {Rotational dislocation of the atlantoaxial joint associated with type 2 odontoid fracture in high energy trauma A case report and review of articles}, abstract ={Background: The combination of atlantoaxial joint dislocation and fracture of the odontoid process is a rare but serious spine injury that causes instability. The estimated frequency of this combined  injury is less than 2% among upper cervical spine dameges. Few clinical cases of mentioned damage has been reported in scientific resources. In this article, we present the prognosis of a patient with atlantoaxial joint dislocation along with odontoid fracture and discuss how to manage this type of combined injury. Case presentation: A 19-year-old man presents with a fracture of the C2 axis in the odontoid process and posterior displacement of the atlas vertebra (C1) relative to C2 due to motor vehicle accident. posterior displacement was observed with bilateral dislocation of the lateral joints. Conservative treatment consisted axial traction with a halo head brace was performed to reduce the atlantoaxial dislocation. Because traction failed, we decided to perform surgery to reduce the dislocation and fix the C1-C2 joint.postoperative X-ray and CT scan were satisfactory. At the 6 months follow-up, the clinical picture was stable and the patient had no major functional problems. Dynamic X-ray Showed good range of motion in flexion and extension. Conclusion: The combination of  atlantoaxial joint dislocation and fracture of the odontoid process is a rare spine injury that is considered serious due to causing  instability. First, we treat the dislocation, then the treatment of the fracture of the odontoid appendage is determined based on the results of displacement and its stability. Conservative treatment of dislocation includes axial traction with a halo head brace. If traction fails, an open reduction should be performed through the posterior approach  with C1-C2 Magerl fixation. If this approach is not possible, occipitocervical fixation is performed. The rarely-used lateral approach has an advantage in this indication, because the atlantoaxial joint exposure is excellent and the option exists to perform anterior transarticular fusion.}, Keywords = {Odontoid fracture, Atlantoaxial rotational dislocation, Occipitocervical stabilization}, volume = {13}, Number = {0}, pages = {49-57}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.49}, url = {http://aums.abzums.ac.ir/article-1-1794-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1794-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {BaradaranBagheri, Ali and Kabir, Kourosh and Taherinia, Ali and Paiman, Fatima sadat}, title = {Compatibility of Brain CT_Scans with valid guidelines criteria in mild traumatic brain injury patients in emergency department of Madani medical education Center in Karaj}, abstract ={Introduction :Brain injury is a prevalent problem in emergency department. Assessing traumatic brain injury (TBI) usually needs imaging, of them Computed Tomography scanning (CT scan) is very useful for detecting brain pathology in these patients. On the other hand in mild TBI patients, CT imaging may be used without indication which leads to overuse and unnecessary harm to patients and also waste of resources. Due to the lack of data in Iran, the study aimed to assess the compatibility of Brain CT Scans with valid guidelines criteria in mild traumatic brain injury patients in emergency department of Madani medical education center in Karaj. Material and methods: A cross-sectional design study were used to assess compatibility of CT scans with different guidelines. A convenient sample of patients with mild TBI who referred to the emergency department of Madani medical education center and had underwent CT scan, entered the study. Patients with other accompanying injuries excluded from the study. Demographic data, mechanism of injury, signs and symptoms of patients were gathered using a check list. Indications for doing CT scans in adults were checked using Neworleans and Canadian guidelines. PECARN guideline also used for children. Data analyzed using SPSS software. Results: 267 patients with the mean age of 35.13 (±22.502) years were evaluated. 168 (62.9%) patients were male and 99 (37.1%) were female. 35 (13.1%) patients according to PECARN+Neworleans guidelines and 127 (47.6%) patients according to PECARN+Canadian guidelines did not have any indication. Only 14 (5.2%) patients had abnormal CT findings. All of them had indications of performing CT scan. It could be estimated that 43 or 157 thousand brain CT scan are performed without indication, which result in wasting more than 23 or 84 billion rials of health system budget. Conclusion: The results of this study indicate the use of valid guideline criteria reduce unnecessary brain CTs, thus preventing the loss of cost, time, manpower and depreciation of devices and also causes reduction of disease caused by the complication of CT scan radiation.}, Keywords = {Brain CT scan, Mild traumatic brain injury, Valid guideline}, volume = {13}, Number = {0}, pages = {58-71}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.58}, url = {http://aums.abzums.ac.ir/article-1-1556-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1556-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Hemmasi, Seyedeh Homa and Hamta, Amir and ZebarjadiBagherpour, Javad and Bahri, Mohamad Hadi}, title = {Investigating the quality of "discharge training" for surgical patients and related factors in Qom educational and therapeutic hospitals in 2019}, abstract ={Background:Although anesthesia and surgery have become less complicated and more successful in the present age than in the past, surgical anxiety and postoperative complications remain strong. The education given to patients can reduce these complications. Therefore, this study was conducted to investigate the effective factors involved in post-surgery training to patients admitted to different surgical wards. Method:This study is a retrospective descriptive-analytical study that conducted in 1399 on 268 patients who underwent surgery in Nekouei, Hedayati, Forqani hospitals were informed with informed consent and in a questionnaire by an impartially trained staff through interviews with Patients were completed at the time of their discharge and the quality of education was assessed and the factors involved were investigated. The personal information of these patients remained completely confidential, so it is not clear which questionnaire belongs to which patient, and in addition, the name of the surgeon remained confidential. Results:Based on the desired surgical group, it was observed that the gender of the patients (P=0.001), the age of the patients (P=0.001), and the type of surgery in them (P=0.001) had a statistically significant relationship with their surgical group, which It is due to the difference in indicators in different surgical groups and the difference in their patients (Table 2). On the other hand, by evaluating and comparing the education status of patients with the information evaluated in them, it was observed that only education (P=0.12) and age of patients (P=0.48) had a statistically significant effect on their education status, so that With the increase in the level of education, the number of trained people has decreased, and the highest frequency and prevalence of trained people are in the age group of 18 to 50 years. Conclusion:Based on the results of this evaluation, some factors affecting the results of patient education are identified, based on this and by relying on these results, the results of education of these patients can be improved.}, Keywords = {Education at discharge, factors related to education, surgery}, volume = {13}, Number = {0}, pages = {72-78}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.72}, url = {http://aums.abzums.ac.ir/article-1-1795-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1795-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Taherinia, Ali and KhademHosseini, Peyman and Rahimi, Jamshid and MohsenZadeh, Yazdan and Toufigh, Seyed Jamal}, title = {Role of Resilience in the Anxiety Symptoms of Coronary Healing Nurses in Alborz University of Medical Sciences}, abstract ={Introduction: One of the most common psychological complications in Covid-19 care nurses is stress and anxiety, especially anxiety disorder. This type of anxiety can be considered as one of the important psychological diagnoses in nurses. One of the positive psychological mechanisms in the treatment of diseases and control of resilience anxiety is resilience. Resilience ensures people's mental health by modifying and minimizing factors such as anxiety. The aim of this study was to determine the role of resilience in anxiety symptoms of corona nurses of Alborz University of Medical Sciences.  Method: The present study is cross-sectional and correlated with the statistical population of nurses involved in Covid-19 wards. Data gathering done by sample characteristics using Beck Anxiety Questionnaire for measuring the clinical anxiety symptoms in the subjects. Using the Connor and Davidson Resilience Questionnaire to measuring resilience of the samples. Result: 28 female and 14 male nurses participated in this study. The average rate of resilience in the studied nurses was 71.05 indicates the high resilience of these people. The average anxiety of the subjects is 7.43. Discussion: The results showed that the general health scores of the nurses did not have a good health status. Resilience rate is high in the nurses. The results show that the average anxiety of the subjects is not high on average. In statistical studies, the results showed that the distribution of scores in the sample in anxiety was normal.}, Keywords = {Covid-19, Resilience, nurse}, volume = {13}, Number = {0}, pages = {79-87}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.79}, url = {http://aums.abzums.ac.ir/article-1-1658-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1658-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Forghani-Ramandi, Mohammad-Moien and Mozhgani, Sayed-Hamidrez}, title = {Determining the key genes and cellular signaling pathways involved in the pathogenesis and development of aggressive types of adult leukemia/lymphoma derived from T (ATLL) cells}, abstract ={Background: Adult T-cell leukemia/lymphoma (ATLL) is a cancer with a very poor prognosis. ATLL has four subgroups, acute, chronic, lymphoma, and smoldering, with very different prognoses. In this study, we tried to better understand the pathogenesis of ATLL and the differences between its subgroups by using gene expression data and bioinformatics methods. Methods: Genes with altered expression were identified among different types of ATLL. In order to determine the key genes, the network of protein interactions between the resulting genes was constructed. After screening the hub genes based on the network centrality indices, the cell signaling pathways related to them were identified. Results:Comparing the acute type with the chronic and silent types, the cell signaling pathways involved in regulating the function of the immune system are expressed differently. In comparison of acute and chronic type with healthy people, genes related to malignancy are involved. In comparing the silenced type with healthy individuals, the pathways related to infections are disrupted. In the secondary comparison, it was found that the genes related to cell proliferation and malignancy in the acute form were expressed more and the genes related to the immune system were less expressed in these patients than in the rest of the population. Conclusion:It seems that manipulations by the virus resulting in immune escape and also in increased proliferation of infected cells have a decisive role in the occurrence of the aggressive type of the disease. Further investigations can lead to the development of new diagnostic methods, determining prognosis and even the detection of targets for gene therapy.}, Keywords = {Adult T-cell leukemia/lymphoma, Human T-cell lymphotropic virus type 1, bioinformatics, ATLL, HTLV-1}, volume = {13}, Number = {0}, pages = {88-102}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.88}, url = {http://aums.abzums.ac.ir/article-1-1789-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1789-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Forghani-Ramandi, Mohammad-Moien and Najafi, Arvi}, title = {Determination of key genes and cellular signaling pathways involved in the resistance of patients with diffuse large B-cell lymphoma to Helicobacter pylori eradication treatment}, abstract ={Background: Diffuse large B-cell lymphoma is the most common invasive non-Hodgkin's lymphoma. There is a strong relationship between Helicobacter pylori infection and the occurrence of this malignancy. It has been seen that some patients with DLBCL in the early stages respond well to Helicobacter pylori eradication treatment, but others are resistant to it. Due to the lack of sufficient knowledge about the occurrence of this resistance, it is necessary to identify mechanisms of resistance. Methods: The gene expression data of sensitive and resistant patients were obtained from GEO site. After determining the genes with altered expression, in order to identify the key genes, the protein interaction network was constructed and the important genes were filtered based on the network centrality indices. Finally, cellular signaling pathways associated with key genes were determined. Results: CXCL8, EGFR, FN1, ICAM1, IL1B, TLR2, TLR4, TNF and VEGFA genes were identified as highly important genes according to the network analysis and the results obtained from the pathway enrichment analysis. Key genes showed a significant relationship with functions related to the regulation of immune cells activation. Conclusion: The results obtained from this study show the significant role of cell functions related to surface receptors and also the regulation of immune cells activation in the occurrence of resistance to treatment. The genes and cellular pathways identified in this study can be used as therapeutic targets and biomarkers for diagnosis, determination of the appropriate treatment method for the patients and prognosis.}, Keywords = {Diffuse large B-cell lymphoma, DLBCL, Bioinformatics, Helicobacter pylori}, volume = {13}, Number = {0}, pages = {103-113}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.103}, url = {http://aums.abzums.ac.ir/article-1-1797-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1797-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Torabizadeh, Roya and Bairami, Amir and Hatami, Shiva and sharifipour, Zhil}, title = {Investigation of Enteropathogenic Bacteria (Salmonella, Shigella ,Escherichia coli) among labour children of Karaj city in the year 2019-2020}, abstract ={Introduction:  Labour child is defined as a child  who is employed between the ages  of 5-17 years and is deprived of the education , training and physical activities necessary for growth that other children benefit from them. Currently, the number of these children is decreasing in developed countries, but it has been increasing in developing countries such as Iran. Due to the unfavorable living conditions these children are prone to contracting various infectious diseases. Such as Bacterial or Parasitic intestinal infections . the purpose of this study was to investigate the prevalence of intestinal bacterial in labour children of( Karaj city,Iran) in order to diagnose and treatment them. Methods: 200 labour or working children were included in the study ,stool samples were collected from them, and intestinal pathogens were examined by direct culture and direct smear method. Results: In 35 samples, E.coli prevailed, in 27 samples klebsiella prevailed and  in 10 samples salmonella prevailed, also by using E.coli antisera it was determine that the number of EPEC serovar was 15 including : E.coli polygroupI(O26,O55,O111) 7cases،E.coli polygroupII(O86,O127) 3cases،E.coli polygroupIII (O125,O126 ,O128) 3 cases ,E.coli polygroup IV(O20 ,O114) 2 cases  and STEC( O157H7) 4 cases. Discussion and conclusion: Living on the street can expose working children to many social harms and various diseases, according to the presence of pathogenic bacteria in the samples found from working children.}, Keywords = {Child labour, Enteropathogenic Bacteria, Salmonella, Shigella, Escherichia coli}, volume = {13}, Number = {1}, pages = {1-8}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.1.1}, url = {http://aums.abzums.ac.ir/article-1-1676-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1676-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Aghaie, Tayebe and Gorgani, Melika and Motallebnezhad, Morteza and Jazayeri, Mir Hadi}, title = {Comparison of the PD-1 expression level in peripheral blood of Multiple Sclerosis and Neuromyelitis Optica patients}, abstract ={Programmed cell death-1 (PD-1) is one of the important co-inhibitory receptors in maintaining tolerance and inhibiting the proliferation and activity of activated immune cells. PD-1: PD-L pathway enhances regulatory T cells proliferation and inhibition of autoreactive T cells and regulates central and peripheral tolerance. This pathway has affected various aspects of the immune system and is of particular importance in a variety of diseases, such as autoimmune diseases. Multiple sclerosis (MS) and Neuromyelitis Optica (NMO) are neurological disorders characterized by inflammation, demyelination by the immune system, and axonal and neuronal damage in the CNS. The clinical manifestations of NMO are very similar to MS and lead to a misdiagnosis. Therefore, the existence of specific diagnostic markers is of particular importance for correct diagnosis. Here, we examined the expression of the PD-1 gene in 40 MS patients, 20 NMO patients, and 15 healthy individuals. Thus, after RNA extraction from human blood and cDNA synthesis, gene expression of PD-1 was investigated using quantitative real-time PCR technique. The results show that the PD-1 mRNA expression in the peripheral blood of the MS group was significantly increased in comparison to that of the NMO group and healthy group (p= 0.0008, p= 0.0024, respectively). However, there was no significant difference in PD-1 mRNA expression between the NMO group and the healthy group.}, Keywords = {Multiple sclerosis, Neuromyelitis Optica, Misdiagnosis, PD-1, PD-L, T cell, Gene expression}, volume = {13}, Number = {1}, pages = {9-16}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.1.9}, url = {http://aums.abzums.ac.ir/article-1-1666-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1666-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {DehghanBanadkooki, Somayeh and Donyavi, Zakiyeh and Hafedi, Avi}, title = {Effect of Spreader Taper on Root Fracture Resistance in Canals Obturated with Gutta-Percha/AH26 By Lateral Condensation Technique}, abstract ={Aim and background: This study was performed to investigate the effect of taper of stainless-steel spreader on root fracture resistance by applying the same force. Materials and methods: This study was performed on forty extracted lateral maxillary teeth. Root canal preparation was performed on all samples. Before canal obturation, samples were divided in four groups randomly. Group 1, lateral condensation using a stainless-steel spreader with 2% taper. Group 2 was obturated with a stainless-steel spreader of the same material but with 4% taper, as in group one. In group three or negative control, the canals were not obturated, and in group four or positive control, lateral condensation technique was performed until cracks were created in the root. After 72-hour incubation and thermocycling, fracture resistance test was done. Data obtained were statistically analysed using SPSS, one way ANOVA and post Hoc Bonferouni. Results: For statistical analysis, the significance level was p<0.05.  Fracture resistance values were as follow, respectively: negative control> 25/0.02 spreader group> 25/0.04 spreader group> positive control. Fracture resistance in obturated canals by 25/0.02 or 25/0.04 spreaders and unobturated canal was significantly more than positive control, although pair by pair comparison of these three groups showed no significant difference. Conclusion: Using 25/0.02 and 25/0.04 stainless steel spreaders in lateral condensation technique didn’t make a significant reduction in fracture resistance values of the roots.}, Keywords = {Fracture Resistance, Lateral condensation, Taper,Spreader}, volume = {13}, Number = {1}, pages = {17-25}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.1.17}, url = {http://aums.abzums.ac.ir/article-1-1634-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1634-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Azimi-Alamouty, Mohammad and Habibi, , Mohammad-Amin and Ebrahimi, Amin and Jamalpoor, Zahr}, title = {Investigating the effect of amniotic membrane solution on the behavior of human umbilical cord mesenchymal stem cells in an in vitro condition}, abstract ={Introduction and objectives: Mesenchymal stem cells are a promising approach for the regeneration of damaged tissues. Engineered scaffolds loaded with cells is one of the methods of cell transplantation at the site of injury. However, viability of the cells loaded in the scaffold is still a challenge. Growth factors have a proven role in increasing the metabolic activity of cells. Amniotic membrane solution is a rich source of growth factor. The aim of this study was to determine the optimal concentration of amniotic membrane solution on the behavior of mesenchymal stem cells in in vitro.   Methods: Amniotic membrane solution was prepared by enzymatic method in predetermined concentrations. Mesenchymal stem cells loaded in hydrogel were treated with different concentrations. The viability, proliferation, and metabolic activity of the cells were evaluated. Results: Cytotoxicity of amniotic membrane solution was measured by MTT method. Increasing the concentration from 0.1 to 1 mg/ml did not show any toxicity, and at the concentration of 1.5 mg/ml, a decrease in optical density (OD=0.58±0.012) was observed compared to the control (OD=0.39±0.014). The metabolic activity of the cell loaded in the hydrogel at a concentration of 1 mg/ml had a significant increase compared to the control group ( p 0.012) and the amount of DNA content in this group (19.6 ± 0.9 ng/matrix) confirmed it. Conclusion: It is suggested that amniotic membrane solution as a rich source of growth factor with an optimal dose of 1mg/ml increases the viability and metabolic activity of the MSCs-loaded scaffold for cell therapy.}, Keywords = {amniotic membrane, mesenchymal stem cell, cell migration, cell proliferation}, volume = {13}, Number = {1}, pages = {26-33}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.1.26}, url = {http://aums.abzums.ac.ir/article-1-1610-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1610-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {GhorbanFallah, Faezeh and Habibollahi, Hadi and AhmadSharbafi, Mehrnaz}, title = {Studying the change in transcription level of beta-catenin gene in PANC-1 pancreatic cancer cell line treated with clove extract}, abstract ={Pancreatic cancer development is a complex biological process in which various genes are involved. The β-catenin/Wnt signaling pathway plays an important role in the development of pancreatic cancer. In this research, the effect of clove polyphenol extract on PANC-1 pancreatic cancer cell line and the changes in β-catenin gene expression were evaluated. PANC-1 pancreatic cancer cell line was purchased from the Royan center of Isfahan. After successive passages in order to perform MTT assay, the cells were cultured in 96-well culture plates and treated for 24 hours with different concentrations of clove plant extract, and the absorbance of the samples was determined at a wavelength of 570 nm. By interpreting the results of the MTT test, the IC50 value of clove extract was determined. Based on IC50, PANC1 cells were cultured under treatment with extract and without treatment (control), and then using the kit, RNA extraction and cDNA synthesis were done from the cells. Using specific primers for β-catenin gene and actin reference gene, real-time PCR was performed and then interpreted by 2-DDCT method. The compounds in clove extract were also determined by mass GC method. The results of MTT assay showed that the IC50 of clove extract in PANC1 cell line is in the range of 10 mg/ml and with increasing concentration of clove extract, cell survival is completely decreased. Examining the transcriptional change of β-catenin gene under the treatment of IC50 concentration of clove extract also showed that this extract is able to decrease the expression of this gene by 1.29 times at the level of transcription at a significant level of p<0.05, which due to the unconventional increase of β-catenin catenin in all types of cancer, reducing the expression of this gene under the treatment of clove extract can be desirable.}, Keywords = {Pancreatic cancer, PANC-1 cell line, beta-catenin gene, clove extract}, volume = {13}, Number = {1}, pages = {34-43}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.1.34}, url = {http://aums.abzums.ac.ir/article-1-1674-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1674-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Mokhtari, Mokhtar and Shariati, Mehrdad and Ajdari, Dorna and Moghadamnia, Davoo}, title = {The effect of saffron hydroalcoholic extract on changes in liver-related biochemical factors following chronic vitamin A intoxication in adult male rats}, abstract ={Background: Saffron has anti-seizure, anti-depressant, anti-inflammatory, anti-tumor and memory improvement drugs. In this study, the effect of saffron hydroalcoholic extract on changes in liver-related biochemical factors following chronic vitamin A intoxication in adult male rats was investigated. Methods: For this purpose, 48 adult male Wistar rats weighing approximately 200±20 g were divided into 6 groups of 8. Control group: did not receive any drug treatment, sham group: received only solvent extract, experimental groups 1: Hydroalcoholic extract of saffron alone received 50 mg / kg for 15 days. Experimental group 2: Vitamin A received 50,000 IU for 15 days. Experimental groups 3 and 4: First, they received 50,000 IU of vitamin A for 15 days and then received saffron hydroalcoholic extract at 50 and 80 mg / kg, respectively, for 21 days. At the end of the experiment, the body weight of the animals was measured. Blood samples were taken from the heart and albumin, bilirubin and total protein levels were measured. The results were analyzed using ANOVA and Tukey test. Results: The mean body weight in the groups receiving vitamin A and saffron hydroalcoholic extract together and alone did not show a significant change compared to the control and sham groups. Mean serum levels of total protein and albumin in experimental group 2 receiving vitamin A and experimental group 3 showed a significant decrease compared to control and control groups. The mean serum levels of total protein and albumin in experimental group 4 showed a significant increase compared to experimental group 2 receiving vitamin A. The mean serum level of total bilirubin in experimental group 2 receiving vitamin A and experimental group 3 showed a significant increase compared to the control and sham groups. The mean serum level of total bilirubin in experimental group 4 showed a significant decrease compared to experimental group 2 receiving vitamin A (P> 0.05). Conclusion: Saffron hydroalcoholic extract has a protective effect on changes in liver-related biochemical factors following chronic vitamin A poisoning in adult male rats.}, Keywords = {Saffron, Albumin, Total protein, Bilirubin, Adult male rat}, volume = {13}, Number = {1}, pages = {44-52}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.1.44}, url = {http://aums.abzums.ac.ir/article-1-1533-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1533-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Hormati, Najmeh and Hosseini, Seyed Ebrahim and Fereidooni, Faeze and Mottaghi, Rez}, title = {Comparison of the effect of Iranian and non-Iranian wordless Quiet music (Mozart\'s modern classical style) on the concentration level of 5-8 year old children with attention deficit/hyperactivity disorder in special care centers for these children in Shiraz city}, abstract ={Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is one of the relatively common diseases of children all over the world, which is associated with symptoms such as aggression, hyperactivity, anxiety and lack of concentration. Considering the side effects of drug therapy, the use of non-pharmacological methods should be considered. This study was conducted with the aim of comparing the effect of Iranian and non-Iranian soft wordless music on the improvement of ADHD symptoms. Materials and methods: The current semi-experimental research with a pre-test and post-test design with a control group was conducted in 2014 at Zand Institute of Higher Education in Shiraz on 60 ADHD children. With the available sampling method, 60 children with attention deficit/hyperactivity disorder were randomly divided into two experimental groups and one control group (20 people in each group). Experimental groups 1 and 2 were subjected to 20 sessions of 60-minute Iranian and non-Iranian music therapy (Mozart), respectively. The participants were evaluated with the demographic information form and Connors parent test (1960) in 2 stages. Data analysis was done by one-way covariance analysis with the SPSS version 24 statistical package at a significance level of p<0.05. Findings: There was no significant difference between the groups in terms of age and gender (P<0.05). The results showed that there is a significant difference between the average scores of Iranian and non-Iranian Aram music groups at p<0.05. There is a significant difference between the average scores of Iranian Aram music groups and the control at p<0.001, but there is no significant difference between the average scores of non-Iranian Aram music groups and the control. Conclusion: The results of the present research in relation to the comparison of 2 types of calm and wordless Iranian music by Chashm Azar and classical and modern music by Mozart show that music that is compatible with the patient's culture can improve children with ADHD.}, Keywords = {ADHD, Iranian music, Mozart's music}, volume = {13}, Number = {1}, pages = {53-62}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.1.53}, url = {http://aums.abzums.ac.ir/article-1-1646-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1646-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Mazloom, Roham and Bayat, Gholamreza and Khalili, Azadeh and Arabi, Mohse}, title = {An overview of the Physiome Project; a perspective focusing on interdisciplinary studies in the medical sciences}, abstract ={The concept of the Physiome Project was presented to provide a quantitative description of the physiological dynamics and functional behavior of the intact organism as a whole. The human body is a complex system, and this complexity is present in all components from genes to environment, lifestyle, and aging. The definitive goal of the Physiome Project is to create a "virtual physiological human" by assembling reliable and advanced computational models so that it can be studied and evaluated with a holistic perspective through system's theory in the laboratory and therapeutic settings. This process is started through the creation of modeling at molecular and cellular levels, and by connecting its components with the help of virtual reality, it will be considered as a connected whole to form a virtual physiological human. To achieve this goal in the Physiome Project, other branches of knowledge along with medical sciences are used as interdisciplinary collaborations. Although this project has had various ups and downs, but in general, it has made acceptable progress in applying different sciences together, and therefore, it seems that the process of the Physiome Project can be used to create a suitable model in the formation of interdisciplinary studies.}, Keywords = {Physiology, Virtual Reality, Systems Theory, Computational Models}, volume = {13}, Number = {1}, pages = {63-70}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.1.63}, url = {http://aums.abzums.ac.ir/article-1-1602-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1602-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Hakemi, Monir Sadat and Tavakoli, Farnaz and Abdollahpour, Esmat and Masoudi, Yasin and Nassiri, Amir Ahm}, title = {Evaluation of prevalence and risk factors for superior vena cava stenosis in patients on hemodialysis through a tunneled cuffed catheter}, abstract ={Background:Superior vena cava (SVC) stenosis is a major cause of vascular access problem and is associated with morbidity and mortality in hemodialysis patients. This study was done to determine the prevalence and risk factors for SVC stenosis in patients on HD by tunneled cuffed catheter (TCC) in Shariati hospital. Methods:All patients on chronic HD with TCC were enrolled in the study. SVC stenosis was defined as diameter reduction more than 50% by CT Angiography. Demographic characteristics including age, gender, BMI, history of diabetes mellitus (DM) were evaluated. Moreover, location of TCC insertion (subclavian, Jugular), duration of catheter carriage, and history of previous catheterization were recorded. Results:This study was done on 40 patients. SVC stenosis was diagnosed in 3 out of 40 (7.5%) patients. Only one patient was symptomatic and presented with face and neck edema. All 3 patients were female. However, there was no significant correlation between gender of the patients and SVC stenosis. Two of patients with SVC stenosis had history of DM, but we did not find significant relationship between DM and SVC stenosis. SVC stenosis was significantly more common in patients with subclavian catheter in comparison to jugular catheter (P=0.02). There was significant correlation between duration of catheter carriage and SVC stenosis (P=0.02). Conclusion:SVC stenosis was not common and it could be asymptomatic. However, we should consider it in patients on HD by TCC. The duration of TCC carriage should be restricted and subclavian catheterization must be avoided.}, Keywords = {hemodialysis, cuffed catheter, central vein stenosis}, volume = {13}, Number = {2}, pages = {71-76}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.2.71}, url = {http://aums.abzums.ac.ir/article-1-1731-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1731-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Moshaverinia, Maryam and Manifar, Soheila and Fathi, Yaser and Jalouti, Nim}, title = {Assessment of the relationship between background factors and quality of life in head and neck cancer patients undergoing radiotherapy in Imam Khomeini hospital in 2023}, abstract ={Background: Oral complications during and after radiotherapy are common and affect the quality of life.This study was aimed to assess the relationship between underlying factors and oral health related quality of life in head and neck cancer patients undergoing radiotherapy. Methods: This Descriptive-analytical and cross-sectional study was conducted on 85 patients with head and neck cancer referred to the Radiotherapy Center of the Cancer Institute of Imam Khomeini Hospital Complex in Tehran. Sampling was done by "available" sampling method from April to June 2023. Demographic information and information related to the disease were checked in a questionnaire. Also, for the oral health related quality of life, a questionnaire including 26 questions was designed based on the complications and symptoms caused by radiotherapy. Results: There was no significant relationship between age, gender, education, history of smoking or alcohol consumption, smoking or alcohol consumption at the time of completing the questionnaires, type of lesion, week of the radiotherapy course in which the questionnaire was completed, area of ​​malignant lesion and the quality of life questionnaire score.(P>0.05) There was a significant relationship between occupation, marital status, underlying diseases and the quality of life questionnaire score.(P<0.05) Conclusion: The results of this article show a general decrease in the quality of life of head and neck cancer patients undergoing radiotherapy. People with a better job status and married people had a higher quality of life, which could be due to better financial and emotional conditions in these people. People with underlying diseases also reported a higher quality of life, which could be due to getting used to the conditions of the disease and starting radiotherapy with a lower quality of life. These results can help in better implementation of care and in providing necessary support for these people.}, Keywords = {radiotherapy, quality of life, head and neck cancer}, volume = {13}, Number = {2}, pages = {77-88}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.2.77}, url = {http://aums.abzums.ac.ir/article-1-1714-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1714-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Amiri, Siamak and BahramiBabaheidari, Tooran and Hajfiroozabadi, Marj}, title = {The Role of Self-Esteem Dimensions in the Academic Performance of Medical Sciences Students}, abstract ={Introduction: Self-esteem is one of the essential components in maintaining mental and physical health. Individuals who have positive self-esteem are more flexible and able to accept their strengths and weaknesses. The results of studies have shown that increasing self-esteem leads to increased self-confidence and efficiency in students. The aim of this study is to investigate the relationship between different dimensions of self-esteem and academic performance in students of Alborz University of Medical Sciences. Method: This descriptive-correlational study was conducted among 704 students of Alborz University of Medical Sciences in 2020. Data were collected using Cooper Smith's standard self-esteem questionnaire and demographic characteristics questionnaire. The samples were selected randomly and classified according to the number of students in each field. Students' academic performance was obtained using the cumulative grade point average of the past semesters by self-report method. Data were analyzed using descriptive statistics, Pearson correlation tests and multivariate linear regression. Results: The results showed that the mean and standard deviation of self-esteem in the general dimension was 18.24 (4.1), in the social dimension was 5.03 (1.79), in the family dimension was 5.7 (2.15), and in the academic dimension was 5.65 (1.67). Also, there was a significant correlation between academic performance and self-esteem in the general dimension (p < 0.01, r=0.12), social dimension (p < 0.01, r=0.14), family dimension (p < 0.01, r=0.20), and academic dimension (p < 0.01, r=0.34). Multiple linear regression results showed that the academic self-esteem dimension had the greatest effect on academic performance, so with other variables constant, on average, with an increase of one unit in academic self-esteem score, academic performance would increase by 37%. Conclusion: The highest correlation between academic self-esteem and academic performance was observed. It is recommended that instructors pay more attention to this dimension of self-esteem in students in order to improve academic performance in classroom and clinical environments.}, Keywords = {Self-esteem, Academic Performance, Medical sciences students}, volume = {13}, Number = {2}, pages = {89-98}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.2.89}, url = {http://aums.abzums.ac.ir/article-1-1683-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1683-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Choobsaz, Aida and Taher, Mahboobe and Tabatabaee, Seyed Mosa and Hosseinkhanzadeh, Abbas Ali}, title = {The Effectiveness of Emotional Schema Therapy on Death Anxiety Nurses with Obsessive-Compulsive Pathological Personality Traits Working in The Corona Ward}, abstract ={background: The present study was conducted to investigate the effectiveness of emotion-oriented schema therapy on death anxiety in nurses with obsessive-compulsive personality traits. methods: This research was practical and semi-experimental (pre-test, post-test, and follow-up) with a control group. The statistical population was nurses working in social security hospitals from 2021. The statistical sample consisted of 13 people in the experimental group and 13 people in the control group from nurses working in the Corona department, who had an average score on the personality questionnaire of the fifth diagnostic statistical guide and Templer's death anxiety. Experiment and control (13 people in each group) were randomly assigned. Templer's death anxiety scale was used to measure the research variable in the pre- and post-treatment stages. The experimental group was treated with emotional schema therapy for 10 sessions of 120 minutes. The control group did not receive treatment. At the end of the treatment period, the post-test was performed. The data were analyzed with the help of SPSS-24 software and by the variance analysis method with repeated measurements.   Result: The results of the analysis showed that this therapeutic intervention reduces the death anxiety of nurses with obsessive-compulsive personality traits working in the Corona ward. P < 0.01 Conclusion: emotional schema therapy intervention can be one of the effective treatment strategies to improve the death anxiety of nurses with obsessive personality traits. Therefore, holding training courses in this field is recommended.}, Keywords = {emotional schema therapy. nurses. death anxiety}, volume = {13}, Number = {2}, pages = {99-110}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.2.99}, url = {http://aums.abzums.ac.ir/article-1-1655-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1655-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Nazari, Nasim and Imani, Saeed and Pakdaman, Shahla and Shokri, Omi}, title = {Comparison of self-regulation in adolescents with and without symptoms of attention deficit/hyperactivity disorder or sluggish cognitive tempo}, abstract ={Background: studies are trying to differentiate two disorders, Attention deficit/hyperactivity disorder and Sluggish cognitive tempo, due to their similarities. In this regard, the present study was conducted with the aim of comparing self-regulation and substance use tendencies in adolescents with and without symptoms of attention deficit/hyperactivity disorder or sluggish cognitive tempo. Methods: The study was in the frame of Causal Comparative design. The statistical population includes parents and adolescents aged 13 to 17 years with the symptoms of attention-deficit/ hyperactivity disorder, sluggish cognitive tempo and normal adolescents in Karaj in 2022. The method of sampling was available and using it, 150 people (50 with attention deficit/hyperactivity, 50 with sluggish cognitive tempo and 50 normal adolescents) were selected. The tools of data collection were the Rating of Attention deficit hyperactivity disorder, Sluggish Cognitive Tempo Inventory, Adolescent Self-Regulatory Inventory, and Addiction Susceptibility Questionnaire-Adolescent Version. Finally, the data were analyzed using the analysis of variance and Sheffe's post hoc test. Results: The findings showed that the self-regulation scores are respectively and significantly lower in the attention deficit/hyperactivity group, the sluggish cognitive tempo group, and the normal group (p<0.05). There were no significant differences in the scores of substance use tendency between adolescents with attention-deficit/hyperactivity disorder and with sluggish cognitive tempo; But the difference between the two groups compared to normal adolescents was significant. Conclusion: It can be concluded that adolescents with and without symptoms of attention deficit/hyperactivity disorder or sluggish cognitive tempo are different in terms of self-regulation and substance use tendencies.}, Keywords = {attention deficit/hyperactivity disorder, sluggish cognitive tempo, self-regulation, substance use tendency, adolescents}, volume = {13}, Number = {2}, pages = {111-124}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.2.111}, url = {http://aums.abzums.ac.ir/article-1-1678-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1678-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Ghorbani, Ali and Akbari, Mahsa and Rajaee, Roya and Rmezani, Saeedeh and Khaki, Parisa and MoradiShalal, Marziyeh}, title = {Identifying ways to generate income in Alborz University of Medical Sciences Hospitals}, abstract ={Introduction: The transformation of hospitals into a productive center is one of the most important and fundamental issues in the country's health system, and it requires the attention of managers to make hospitals more productive. Therefore, the aim of the present study is to provide solutions to increase the revenues of Alborz University of Medical Sciences hospitals in order to make the hospitals more efficient. Therefore, the present study was conducted in the hospital in order to identify ways to reduce costs and increase income in hospitals covered by Alborz University of Medical Sciences. Methodology: The present research was conducted in a combined (quantitative and qualitative) manner in two stages. First, the current situation in the hospitals of Alborz University of Medical Sciences was examined in terms of cost and income in 1400. Then, using the panel of experts, solutions were presented to increase income and reduce costs according to the weaknesses and the existing condition of the hospitals. Findings: In terms of cost-income difference per bed, Hospital No. 4 was in a better position. Solutions to reduce costs and increase income were identified based on experts' opinions and divided into 5 groups, including human resource management, financial resource management, energy management, equipment maintenance, outsourcing, and control. Conclusion: According to the investigations carried out and the proposed solutions, hospital managers can use the solutions presented in this study to increase the income in the hospital, according to the different dimensions and angles of the quality of healthcare services and according to the plan and goals of each hospital.}, Keywords = {identification, solution, income generation, hospital}, volume = {13}, Number = {2}, pages = {125-136}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.2.125}, url = {http://aums.abzums.ac.ir/article-1-1636-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1636-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Askari, Roohollah and Shafii, Milad and Amini, Mahla and Najafi, Marziyeh and Shamsi, Farimah and Pouragha, Behrooz}, title = {Factors affecting discharge against medical advice from the emergency department of selected hospitals affiliated by Alborz University of Medical Sciences}, abstract ={Background: Examining the rate of leaving with discharge against medical advice (DAMA) despite not completing the treatment process is one of the ways to be aware of patients' satisfaction with the environment and treatment system. Therefore, the study was conducted to investigate the factors affecting emergency department (ED) discharge with personal responsibility of the patient in selected hospitals of Alborz University of Medical Sciences in 2021. Methods: The present study was a descriptive cross-sectional study that was conducted in 2021 in the emergency department of selected hospitals affiliated by Alborz University of Medical Sciences. The sample size included 200 patients leaving ED with personal consent by stratified random method. Data were created by a researcher checklist using descriptive statistics and SPSS24. Results: The most identified reasons for DAMA from the emergency room of the studied hospitals were educational (50%) and attitudinal-emotional (30%); and the least reasons were related to equipment, physical environment and amenities (12%) and Emergency procedures (7%). Conclusion: DAMA can have many undesirable and sometimes irreversible consequences for them, such as death and infection. Planning for training medical students and scheduling the presence of residents and interns in the ED to prevent overcrowding in this department, as well as identifying factors affecting the patient's attitude and feelings, including explaining the treatment process, are recommended.}, Keywords = {Discharge against medical advice, personal responsibility leave, emergency department}, volume = {13}, Number = {2}, pages = {137-148}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.2.137}, url = {http://aums.abzums.ac.ir/article-1-1685-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1685-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Rostami, Hossein and Abesy, Saeed and Alvadari, Hassan and HassanzadehSamarin, Touraj}, title = {Model design of a visionary organization (Alborz University of Medical Sciences)}, abstract ={Background and objectives: All organizations and companies, whether commercial or administrative, are created by the thoughts and ideas of individuals. Visionary organization, by imagining what the future demands and the role that the organization should play in the future, should be one step ahead of their competitors. Therefore, our goal in this study is to achieve a comprehensive model for Alborz University of Medical Sciences with the approach of a visionary organization. Methods: This research has been done in a sequential mixed method (qualitative and quantitative) in two stages. In the first stage, to identify the factors of the model of visionary organization, the data theorizing method of the foundation was used. The interviewees were 10 senior managers of Alborz University of Medical Sciences who were interviewed according to the theoretical saturation rule. In the second stage, Delphi method was used to determine the importance of indicators. Results: In this study, 72 indicators were identified through axial coding that according to causal conditions, intervening conditions, strategies and consequences were developed and the final model was presented. The Delphi method was used to determine the priority of the factors affecting capacity building for the visionary organization and the importance of the strategies found in the interview. Core values, visionary leadership, network structure, coaching, meritocracy, knowledge-based, religious culture, commitment and risk-taking, fearless goals and empowerment were of paramount importance in creating a visionary organization.    Conclusion: Awareness of the indicators of the visionary organization, and in particular the University of Medical Sciences, helps managers, employees and researchers in the optimal understanding of the visionary organization in order to promote productivity.}, Keywords = {organization, vision, visionary organization, medical sciences}, volume = {13}, Number = {2}, pages = {149-162}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.2.149}, url = {http://aums.abzums.ac.ir/article-1-1570-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1570-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Torabizadeh, Mahdi and Pourhang, Nastaran and Shakurnia, Abdolhussein and Salehipourbavarsad, Samaneh}, title = {Eleven-years study of sero-prevalence of Brucellosis among Patients attending in a medical center in southwest Iran (2011-2021)}, abstract ={Abstract Background: Human brucellosis is one of the most common zoonosis infections, with a high prevalence in some regions of the world. It is considered one of the vital health and economic problem worldwide. This study aimed to investigate the trend of seroprevalence of brucellosis among Suspected Patients attending a medical center, in Ahvaz over an 11-year period. Methods: In this cross-sectional descriptive retrospective study, the data of all suspected brucellosis patients between 2011 and 2021 were extracted and analyzed. Wright's serological test 1/80 and above; and the titer of 2ME and Combs' Wright test of 1/40 and above were considered criteria for seropositive of brucellosis. Data were analyzed using SPSS-22. Results: Out of 25241 suspected patients, 645 were seropositive of Brucellosis (seroprevalence rate, 2.6%). The frequency of seropositive cases in men with 193 cases (2.7%) was higher than in women with 452 cases (2.5%) (p=0.14). The highest frequency of positive cases was observed in the age group of 11-20 with 59 cases (3.4%) and the lowest frequency was observed in the age group 1-10 years with 14 cases (1.5%) (p=0.001). The changes trend of seroprevalence of brucellosis in this period of time did not have a constant trend; and were in a zigzag pattern. There is a statistically significant difference between the frequency of positive cases in different years (p=0.001). Conclusion: The findings of this study can be of great value to health care policy makers in understanding the epidemiology of Brucellosis in this region.}, Keywords = {Brucellosis, infectious diseases, Seroprevalence, Sero-epidemiology}, volume = {13}, Number = {3}, pages = {163-171}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.3.163}, url = {http://aums.abzums.ac.ir/article-1-1677-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1677-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Baboli, Parisa and AkbariKamrani, Mahnaz and Farid, Malihe and RajabiNaeeni, Masoumeh}, title = {Iranian Couples’ Perspectives toward Receiving Tele- Marriage Counseling Services}, abstract ={Introduction and purpose:  Premarital counseling is one of the ways to change or reduce irrational beliefs and false expectations from marriage and has effective and significant effects on the quality of people's marriages. The present study was conducted with the aim of investigating the perspective of Iranian couples regarding tele marriage counseling in Karaj city. Methods: This descriptive study was conducted in 2022 on 200 people who referred to marriage centers in Karaj. The tools used in this study include a demographic questionnaire and a telemedicine acceptance questionnaire. The collected data were analyzed using SPSS V23 software. Results: In this study, 56.5% were women and 43.5% were men. The average age of women participating in the research was 28.90 ± 7.51 years and the average age of men was 32.52 ± 5.16 years. Among the participants in this study, 43.5% did not consider premarital education sufficient. The average score obtained by the participants from the feasibility questionnaire is 59.03 ± 07.13. The lowest and highest scores are 29 and 99, respectively. The results of this study showed that almost 75% of the participants agree that using tele marriage counseling can be beneficial in starting their life together. Conclusion: The continuation of tele marriage counseling after the face-to-face meeting of health centers, which is required to register their marriage, can be beneficial in starting their joint life and solve many of their needs and questions.}, Keywords = {Feasibility, Tele Counseling, Youth, Marriage}, volume = {13}, Number = {3}, pages = {172-181}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.3.172}, url = {http://aums.abzums.ac.ir/article-1-1729-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1729-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Jirdashtani, Khorshid and Mousavi, Fatemeh and Asadpour, Leil}, title = {Identification of AmpC beta-lactamase producing clinical isolates of Klebsiella pneumoniae in Guilan and investigation of inhibitory effect of thymol on}, abstract ={Introduction and objectives: Klebsiella pneumoniae is an opportunistic pathogen that plays a major role in the development of nosocomial infections. One of the most important mechanisms of resistance to beta-lactam antibiotics is the production of beta-lactamase enzymes by this bacterium. The aim of this study was to determine the frequency of AmpC beta-lactamase producing clinical isolates of K. pneumoniae in Guilan and investigating the inhibitory effect thymol on these isolates. Methods: Sixty isolates of K. pneumoniae were isolated and identified from clinical laboratories in Rasht during 2022. The pattern of antibiotic susceptibility in isolates was determined and beta-lactamase production was investigated using combined disk method. The presence of AmpC encoding genes including FOX, CITM and DHAM beta-lactamase genes in isolates was determined by PCR. The growth inhibitory effect of thymol on these isolates was determined using disck diffusion and broth microdilution and the efflux inhibitory effect was determined by Cartwheel methods. Results: Among tested isolates 46 (76.6%) showed multi drug resistant phenotype. Of the 22 phenotypically AmpC-producing isolates, CITM and DHAM genes were detected in 12 (20%) and 7 (11.66%) isolates respectively and 4 isolates had both CITM and DHAM genes at the same time. Thymol, showed growth and efflux inhibitory effects against all tested K. pneumoniae isolates.  Conclusion: The results of the present study suggest the necessity of finding a successful treatment option to prevent the spread of infections caused by AmpC producing K. pneumoniae. According to the results, the use of thymol can provide a basis for the development of a new treatment against multi-drug resistant Klebsiella pneumoniae.}, Keywords = {Klebsiella pneumoniae, AmpC beta-lactamase, Antibiotic resistance, Thymol}, volume = {13}, Number = {3}, pages = {182-193}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.3.182}, url = {http://aums.abzums.ac.ir/article-1-1652-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1652-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Tavakoli-Far, Bahareh and Hosseini, Marjan and Goudarzvand, Hadi and Choopani, Samira and Goudarzvand, Mahdi}, title = {GABA Signaling in Spatial Memory changes in Animal Model of Alzheimer’s disease}, abstract ={Introduction: Alzheimer's disease is a progressive disease with mild memory loss that eventually leads to the loss of the ability to conduct conversation and react to the environment. Despite the proven role of the drugs used against the obvious causes of Alzheimer's disease, it still seems impossible to achieve an effective and permanent treatment for the treatment of Alzheimer's disease. So, investigating different angles of GABAergic system signaling can be introduced as a promising target for the development of anti-Alzheimer drugs. Materials and Methods: To induce Alzheimer's disease, the β-amyloid toxin at a dose of 5µg/µl was injected bilaterally into the hippocampus of Wistar male rats, and the rats were then treated with bilateral injection of GABA-A receptor agonist (muscimol) and antagonist (bicuculline), at a dose of 100 ng/µl/side in the hippocampus for 4 days. To assess the spatial memory of the animals, the parameters of the distance traveled by the animals, latency time to reach the hidden platform, and velocity of the animals were analyzed in Morris water maze test. Findings: The distance traveled and the latency time to reach the hidden platform increased in the Morris water test following the injection of beta-amyloid, and the muscimol increased the amount of this memory impairment. The injection of bicuculline could not significantly change the spatial memory of the animals. Conclusion: The results of this study indicate the destructive effect of beta-amyloid toxin on spatial memory, as well as the destructive role of muscimol in memory consolidation and retrieval.}, Keywords = {Alzheimer’s disease, GABA, Spatial memory, Beta-Amyloid}, volume = {13}, Number = {3}, pages = {194-203}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.3.194}, url = {http://aums.abzums.ac.ir/article-1-1804-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1804-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Bararpour, Foroozan and Kurdestani, Fereshte and Abad, Masoumeh and Delgoshaei, Yal}, title = {Providing a model for empowering midwives working in the maternity ward of educational hospitals in Tehran}, abstract ={Introduction: Today, the issue of staff empowerment is more in focus than before because empowering behaviors in hospitals can lead to progress in the field of health care. Therefore, the present study was conducted with the aim of providing an empowerment model for midwives working in the maternity ward of Tehran teaching hospitals. Method: Data were collected based on the combined exploratory research approach in two parts: qualitative (based on foundation data) and quantitative (based on cross-sectional survey method). In the qualitative section, 30 specialists and experts in gynecology and midwifery and educational management were selected by purposive sampling and in the quantitative section, 403 midwives working in the maternity ward of Tehran educational and medical centers were selected by stratified cluster sampling method. The data collection tool was structured in the qualitative part of the interview and researcher-made in the quantitative part. Data analysis in the qualitative part was analyzed by open, axial and selective coding and in the quantitative part by mean indices and exploratory and confirmatory factor analysis. Results: The results of coding based on the data method of the foundation led to the identification of 58 items, 12 components and 4 dimensions including: individual, group, organizational and environmental. Conclusion: The results of the ward shortly after weighting showed that all the indicators of goodness of fit regarding the dimensions of the empowerment model of midwives working in the maternity ward of Tehran educational hospitals have been confirmed.}, Keywords = {empowerment, midwifery, delivery ward, model, educational hospitals}, volume = {13}, Number = {3}, pages = {204-217}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.3.204}, url = {http://aums.abzums.ac.ir/article-1-1377-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1377-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Yousefian, Marzieh and Talaie, Sanam and Eslaminia, Mahdi}, title = {Evaluation of the frequency of lifetime musculoskeletal pain history and its relationship with height, weight and study semester among dental students.}, abstract ={Background: Dental students are prone to musculoskeletal pain, the high prevalence of these problems among students can be the basis for their expansion in the future. Therefore, the present study was designed with the aim of investigating the prevalence of general history of pains and musculoskeletal disorders among dental students of Alborz University of Medical Sciences in 2022. Methods: In this descriptive-analytical and cross-sectional study, 161 students were interested in participating in the study. This study was conducted using a questionnaire that included demographic questions and the Persian version of the Nordic Standard Questionnaire. The data of this study were analyzed using chi-square and Fisher's exact tests and SPSS version 22 software. Results: The results showed that 79.6% of students had experienced skeletal problems in the past. The most common places of conflict were the neck, lower back and shoulders. The results showed a higher prevalence of these disorders in female students. In this study, the existing symptoms had a statistically significant relationship with gender, academic semester, physical activity and clinical activity of the students. Conclusion: The prevalence of musculoskeletal pain among the students of this study was relatively high, which indicates the need to pay more attention to the proper training of ergonomic principles in order to prevent the spread of these problems in this group.}, Keywords = {Prevalence, Musculoskeletal disease, Student, Dentistry}, volume = {13}, Number = {3}, pages = {218-227}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.3.218}, url = {http://aums.abzums.ac.ir/article-1-1687-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1687-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Aghabarary, Maryam and Khedmatizare, Mahsa and Esmaeili, Ali and Shirinbak, Iman and Norouzinia, Roohangiz}, title = {Assessment of Alborz University of Medical Sciences Dental Students\' Knowledge of Medical Emergencies}, abstract ={Background and Aim: Lack of necessary awareness and misdiagnosis can have serious consequences in dental emergencies, potentially causing irreparable harm to the patient's health. This study aimed to assess dental students' knowledge at Alborz University of Medical Sciences regarding medical emergencies in 2019. Materials and Methods:This descriptive, cross-sectional study included all dental students from the 6th to 12th semesters at Alborz University of Medical Sciences (100 students) using a census method. The data collection tool was a questionnaire consisting of three sections: demographic information, the necessity and sufficiency of learning about medical emergencies, and dental students' knowledge of medical emergencies. The collected data were analyzed using SPSS software version 21 and descriptive and analytical statistics at a significance level of P < 0.05. Results:Out of 100 students, 90 completed the questionnaire. The mean knowledge score of the students was 9.63 ± 2.73, with the highest score being 15. 71.1% of participants agreed that the method of teaching medical emergencies should be changed. Additionally, 86.7% of the students felt the need for retraining in emergencies and how to handle them. There was a statistically significant difference between knowledge scores and the academic semester (P =0.01) and the history of attending cardiopulmonary resuscitation workshops (P = 0.03). Conclusion:The knowledge of Alborz University of Medical Sciences dental students regarding medical emergencies was poor and unsatisfactory. The findings of this study, consistent with the results of other studies, highlight the necessity of reviewing and revising the curriculum related to medical emergencies in dentistry.}, Keywords = {Medical Emergencies, Knowledge, Dental Student}, volume = {13}, Number = {3}, pages = {228-237}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.3.228}, url = {http://aums.abzums.ac.ir/article-1-1684-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1684-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Najafi, Marziyeh and Pouragha, Behrooz}, title = {Evaluation and dissemination of health data: a letter to the editor}, abstract ={An organization needs to effectively communicate its performance results to distinguish itself. This not only helps attract necessary resources but also addresses any challenges that may arise. In the context of the intense work environment within health organizations and numerous monitoring and inspection bodies, it is essential to empower health system managers and employees. Their active involvement in evaluating performance and disseminating health program results is crucial to the process.}, Keywords = {evaluation, dissemination, data sharing, health}, volume = {13}, Number = {3}, pages = {238-241}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.3.238}, url = {http://aums.abzums.ac.ir/article-1-1711-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1711-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Tavakoli-Far, Bahareh and Hosseini, Asieh and Fallah-Huseini, Hasan and Mohammdi, Mahdi and Goudarzvand, Mahdi}, title = {The Anti-diabetic Effect of the Mixture of Trigonella Foenum-graecum, Vaccinium Arctostaphylost, Silibum Marianum, dioica Urtica, Melissa Officinalis and Citrulluscolocynthis Extracts in the Diabetic Rat Animal Model and Evaluation of Possible Liver Complications.}, abstract ={Background: Diabetes Mellitus is a metabolic disorder characterized by insulin deficiency or dysfunction. This study aimed to investigate the anti-diabetic effects of a mixture of extracts from "Trigonella foenum-graecum", "Vaccinium arctostaphylos", "Silybum marianum", "Urtica dioica", "Melissa officinalis", and "Citrullus colocynthis" in a diabetic rat model, as well as to evaluate potential liver complications associated with this extract. Methods: In this experimental study, thirty male Wistar rats were rendered diabetic through intraperitoneal administration of alloxan (60 mg/kg). One week post-induction, diabetic rats were randomly assigned to five groups of six. The negative control group received distilled water via gavage, the positive control group received metformin (100 mg/kg), and three experimental groups received daily gavage of the plant extract mixture at doses of 150, 300, and 600 mg/kg, respectively. After 30 days of treatment, blood samples were collected from the tail to assess fasting blood sugar (FBS) and liver biomarkers. Subsequently, the rats were anesthetized with ketamine and xylazine, and liver tissue was prepared for histopathological evaluation using hematoxylin-eosin staining and light microscopy. Results: The extract at doses of 300 and 600 mg/kg significantly reduced FBS and hpp2 levels. However, the 600 mg/kg dose resulted in a significant increase in liver enzymes and induced liver tissue damage. Conclusion: The mixture of plant extracts demonstrated an anti-diabetic effect at a dosage of 300 mg/kg without toxic effects on the liver. These findings suggest potential therapeutic benefits of the extract in managing diabetes while highlighting the need for caution at higher dosages.}, Keywords = {Diabetes Mellitus, Antidiabetic Agents, Herbal Medicine, Liver Diseases, Rats}, volume = {13}, Number = {4}, pages = {242-253}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.4.242}, url = {http://aums.abzums.ac.ir/article-1-1823-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1823-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Norouzinia, Roohangiz and Shyasi, Karim and Khedmatizare, Mahsa and Rahmatpour, Pardis}, title = {Designing and Evaluating Psychometric Properties of two scales of the Factors Contributing to Errors and Reporting Barriers in the Operating Room from the Viewpoints of Student}, abstract ={Introduction: Patient safety is crucial for effective healthcare delivery, and operating rooms (ORs) are among the most hazardous environments in hospitals. Identifying factors that contribute to errors and barriers to reporting them is essential. This study aimed to design and evaluate the psychometric properties of scales measuring factors influencing error occurrence and barriers to error reporting in the OR, as perceived by operating room and anesthesia students in 2022. Methods: This cross-sectional analytical study was conducted in 2022 with 270 operating room and anesthesia students from Alborz University of Medical Sciences. Two scales were developed: one for “factors affecting the occurrence of errors” and another for “barriers to error reporting,” informed by literature review and expert panel insights. The scales underwent evaluation for face, content, and construct validity, as well as reliability assessment. Results: Following revisions for face validity, the content validity ratio (CVR) and content validity index (CVI) for all items exceeded 0.62 and 0.7, respectively. Exploratory factor analysis revealed four factors for the error occurrence scale: individual factors (8 items), educational-skill factors (6 items), environmental factors (4 items), and managerial factors (4 items). Cronbach's alpha values ranged from 0.79 to 0.90, and McDonald's omega values from 0.7 to 0.87. For the error reporting scale, three factors emerged: legal consequences (11 items), management factors (4 items), and reporting process (4 items). Cronbach's alpha for these factors ranged from 0.86 to 0.95, and McDonald's omega from 0.7 to 0.89. Conclusion: The developed scales demonstrated acceptable validity and reliability, making them suitable for assessing the factors influencing errors and reporting barriers in ORs from the perspective of operating room and anesthesia students. Addressing these factors can enable educational and medical managers to implement effective strategies to enhance patient safety by reducing errors and improving the reporting process in hospital ORs.}, Keywords = {Patient safety, Operating Rooms, Medical Errors, Educational Measurement, Psychometrics}, volume = {13}, Number = {4}, pages = {254-264}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.4.254}, url = {http://aums.abzums.ac.ir/article-1-1686-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1686-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Rajaian, Leila and Asle-Rousta, Masoumeh}, title = {Effect of parsley (Petroselinum crispum) extract on memory impairment and anxiety induced by immobilization stress in adult male rats}, abstract ={Background and purpose:  Chronic immobilization stress can damage the nervous system, leading to learning and memory disorders, anxiety, and depression. Parsley (Petroselinum crispum) is known for its antioxidant, anti-diabetic, anti-inflammatory, and hepatoprotective properties. This study investigates the effects of hydroalcoholic extract of parsley on learning, spatial memory, and anxiety behavior in adult male Wistar rats subjected to chronic immobility stress. Materials and methods: Sixty rats were divided into six groups: control, stress, Parsley 1 (1 mg/kg), Parsley 2 (2 mg/kg), stress-parsley 1, and stress-parsley 2. For 21 consecutive days, rats were restrained for 6 hours daily to induce stress. Hydroalcoholic extracts of parsley were administered via gavage at doses of 1 and 2 mg/kg during this period. Spatial learning and memory were assessed using the Morris water maze, while anxiety behavior was evaluated with the elevated plus maze. Results: In the Morris water maze, stress-parsley groups 1 and 2 showed a significant reduction in the time and distance traveled to reach the hidden platform compared to the stress group (p < 0.01 and p < 0.05, respectively). In the probe test, these groups spent a greater distance and time in the target quadrant compared to the stress group (stress-parsley group 1, p < 0.05; stress-parsley group 2, p < 0.01). Additionally, the elevated plus maze results indicated that the percentage of entries into the open arm and time spent in this arm were significantly higher in the stress-parsley groups compared to the stress group (p < 0.05). Conclusion: Hydroalcoholic extract of parsley improved learning and spatial memory while reducing anxiety behavior in rats exposed to chronic immobility stress, suggesting its potential therapeutic effects for stress-induced disorders.}, Keywords = {Parsley (Petroselinum crispum), Spatial memory, Anxiety}, volume = {13}, Number = {4}, pages = {265-275}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.4.265}, url = {http://aums.abzums.ac.ir/article-1-1650-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1650-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Fallah, Nafise and Babaei, Azadeh and Momeni, Zahr}, title = {Antibacterial effects of Trigonella foenum-graceum L. and Kellusia odoratissima Mozaff versus 0.2% chlorhexidine on Streptococcus mutans count: An in vitro study}, abstract ={Introduction Tooth decay is a prevalent chronic disease worldwide; preventive care is essential for its management. Despite some side effects, Chlorhexidine mouthwash is the gold standard for controlling plaque and preventing caries. This study evaluates the antibacterial effects of "Trigonella foenum-graceum" L. and "Kellusia odoratissima" Mozaff extracts on "Streptococcus mutans" compared to 0.2% chlorhexidine mouthwash. Materials & Methods This laboratory study involved preparing herbal extracts of "Trigonella foenum-graceum" L. and "Kellusia odoratissima" Mozaff. The Well Diffusion Agar test measured the inhibition zone diameter at a concentration of 100,000 ppm for the extracts and chlorhexidine mouthwash, with chlorhexidine and distilled water serving as positive and negative controls, respectively. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were determined for the extracts and mouthwash. Finally, the "Streptococcus mutans" count was assessed after exposure to the extracts and mouthwash. Data were analyzed using SPSS 26.0, applying the Kruskal-Wallis test for group comparisons and the Mann-Whitney U test for pairwise comparisons. Results The study reported three key findings. The inhibition zone diameters were 19 mm for chlorhexidine mouthwash, 0 mm for "Trigonella foenum-graceum" L., and 13 mm for "Kellusia odoratissima” Mozaff. MIC values were 6250 ppm for chlorhexidine, >100000 ppm for "Trigonella foenum-graceum", and 50000 ppm for "Kellusia odoratissima", with corresponding MBC values of 12500 ppm, >100000 ppm, and 100000 ppm. Significant differences in bacterial reduction percentages were noted after 30 minutes and 6 hours (both: p<0.001), with chlorhexidine showing the highest efficacy at 30 minutes, while "Kellusia odoratissima" Mozaff had the highest efficacy at 6 hours. Conclusion This study demonstrated that "Kellusia odoratissima" Mozaff extract has antibacterial effects comparable to chlorhexidine, while "Trigonella foenum-graceum" L. showed limited antibacterial activity against "Streptococcus mutans".}, Keywords = {Dental caries, Chlorhexidine, Streptococcus mutans, Herbal Medicine, Minimum Inhibitory Concentration}, volume = {13}, Number = {4}, pages = {276-289}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.4.276}, url = {http://aums.abzums.ac.ir/article-1-1762-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1762-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {AbbasiKhoshsirat, Nahid and Samimisedeh, Parham}, title = {A 44-year-old Female Patient with Multiple Sclerosis (MS) being treated with Rituximab who has also tested positive for Covid-19}, abstract ={In March 2020, the World Health Organization announced that the disease caused by the SARS-COV-2 virus (COVID-19) had become a pandemic. This virus was first identified in Wuhan, China. Among the high-risk groups during the COVID-19 pandemic are individuals with multiple sclerosis (MS). Many experienced practitioners in the treatment of MS have noted that it is still unclear whether MS treatment with medication affects the susceptibility to or the clinical severity of COVID-19 infection. However, based on most current articles, medications with the highest levels of immunosuppression (such as CD-20 inhibitors like Rituximab) are likely not suitable for treating MS patients during the COVID-19 epidemic, although there is no scientific evidence to prove this. This study examines a 44-year-old woman with known MS who was treated with Zytux (Rituximab) and received her last dose in early February 2020, coinciding with the onset of the COVID-19 epidemic. On March 21, 2020, less than a month after the injection, she presented with symptoms of cough, fever, and myalgia, and was ultimately diagnosed with COVID-19. The patient was hospitalized and died during admission due to respiratory failure.}, Keywords = {Multiple Sclerosis, Rituximab, COVID-19, Immunosuppression, Respiratory Failure}, volume = {13}, Number = {4}, pages = {290-294}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.4.290}, url = {http://aums.abzums.ac.ir/article-1-1203-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1203-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Noorian, Shahab and Saeedi, Peym}, title = {An Iranian Adolescent with Disorders of Sex Development: A Case Report of 46,XX Male Disorder and Literature Review}, abstract ={The 46,XX male disorder of sexual development is a rare condition, occurring in approximately one in 20,000 live male births. Clinical manifestations can include testicular atrophy, azoospermia, gynecomastia, short stature, cryptorchidism, hypospadias, and micropenis. We present the case of a 13-year-old Iranian boy referred for delayed puberty. Physical examination revealed small testes and micropenis, corresponding to a Tanner stage of G1 for genitalia and P3-4 for pubic hair. Laboratory tests indicated hypergonadotropic hypogonadism, and karyotyping confirmed a 46,XX karyotype. The patient was started on testosterone enanthate at a dosage of 300 mg every three weeks. Additionally, long-term psychological support and regular gonadal monitoring were incorporated into the management plan.}, Keywords = {Case report Sexual Development Disorders, Testosterone, Puberty Disorders, Karyotype, Hypogonadism.}, volume = {13}, Number = {4}, pages = {295-299}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.4.295}, url = {http://aums.abzums.ac.ir/article-1-1809-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1809-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {Behzad, Hadi and Kafashan, Setareh and EslamiZahraii, Ali and RezvaniAmin, Mahmoud and Mohammadbaigi, Ahm}, title = {A False Negative MRI: Hidden case of Meniere\'s disease in children}, abstract ={Meniere's disease is characterized by recurrent episodes of vertigo, sensorineural hearing loss, tinnitus, and aural fullness, with endolymphatic hydrops being the most significant histopathological change associated with the condition. The etiology of Meniere's disease and the connection between its symptoms and endolymphatic hydrops remain unclear and controversial. Approximately 3% of patients with Meniere's disease are pediatric, leading to a scarcity of studies focused on this demographic. This report presents a rare case of Meniere's disease in a child. The patient was a 14-year-old girl who visited the Echo Hearing-Balance Clinic in Mashhad, reporting hearing loss and tinnitus. Evaluations revealed low-frequency hearing loss, and MRI results were completely normal. A comprehensive assessment, including medical history, audiological findings, electrophysiological tests, and vestibular evaluations, indicated a diagnosis of Meniere's disease.}, Keywords = {Meniere Disease, Hearing Loss, Vertigo, Tinnitus, Pediatric}, volume = {13}, Number = {4}, pages = {300-306}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.4.300}, url = {http://aums.abzums.ac.ir/article-1-1695-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1695-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} } @article{ author = {AbbasiKhoshsirat, Nahid and Samimisedeh, Parham}, title = {A 76-year-old patient with COVID-19 and cerebral hemorrhage}, abstract ={In March 2020, the World Health Organization (WHO) announced that the disease caused by the SARS-COV-2 virus (COVID-19) is a pandemic. The initial symptoms of COVID-19 typically include fever, dry cough, and fatigue. Although cerebrovascular symptoms and strokes have also been mentioned as complications of COVID-19, the exact pathophysiology of these conditions is still not fully understood, and the route of virus entry into the nervous system remains unclear, with various hypotheses proposed. Regarding brain hemorrhage and its connection to COVID-19, a study raised the question of whether COVID-19 is the cause of this complication or merely a coincidence. It has been hypothesized that the angiotensin-converting enzyme 2 (ACE2) receptor, present in the endothelial cells of cerebral vessels and involved in vascular autoregulation and cerebral blood flow, may be affected by COVID-19, potentially leading to disturbances in cerebral autoregulation and ultimately resulting in the rupture of cerebral vessels. This case report presents a 76-year-old man with brain hemorrhage and concurrent COVID-19, confirmed by PCR testing.}, Keywords = {COVID-19, Brain Hemorrhage, Cerebrovascular Disorders, Case Reports}, volume = {13}, Number = {4}, pages = {307-310}, publisher = {Alborz University of Medical sciences}, doi = {10.61186/aums.13.4.307}, url = {http://aums.abzums.ac.ir/article-1-1204-en.html}, eprint = {http://aums.abzums.ac.ir/article-1-1204-en.pdf}, journal = {Alborz University Medical Journal}, issn = {2322-3839}, eissn = {2588-3046}, year = {2024} }