fa مروری بر تکنولوژی انتقال ژن با استفاده از نانوتکنولوژی در تشخیص و درمان بیماریها عمومى General پژوهشی کاربردی Original <div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:16.0pt"><span b="" nazanin="" style="font-family:">مقدمه</span></span></b><b><span dir="LTR" lang="EN-US" style="font-size:16.0pt"><span new="" roman="" style="font-family:" times="">:</span></span></b> <span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">امروزه روشهای مختلفی برای انتقال ژن ها و داروها </span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">در تشخیص و درمان بر اساس نوع بیماری استفاده میشود</span></span></span><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">.</span></span></span> <span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">نانو ذرات متنوعی امروزه در دسترس هستند</span></span></span><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">. </span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">در این مقاله استفاده از نانو ذرات و انواع ان </span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#221f1f">در انتقال داروها و ژنها در بیماریهای مختلف </span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">مورد بررسی قرار می گیرد.</span></span></span><b> </b></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:">روش کار: &nbsp;</span></span></b><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:">در این مطالعه مروری، </span></span><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">جستجوی اولیه در پایگاههای</span></span></span><span dir="LTR" lang="EN-US" style="font-size:14.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#1f1f1f">PubMed, Ovid, Google Scholar </span></span></span>&nbsp;<span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">و </span></span></span><span dir="LTR" lang="EN-US" style="font-size:14.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#1f1f1f">Web of Science</span></span></span> &nbsp;<span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">انجام شد. </span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">دو هزار مقاله اصیل و مروری</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#242424"> به زبان انگلیسی دارای متن کامل با روش تحلیل محتوای مستقیم انتخاب شدند.</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f"> از بین آنها یکصد مقاله مورد مطالعه و بررسی</span></span></span><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f"> نهایی</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f"> قرار گرفت.</span></span></span> <span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f"></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">یافته ها: </span></span></span></b><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">یافته ها نشان میدهد که از نانوذرات در انتقال ژن و دارو، تشخیص سریعتر تومور و همچنین انتقال هدفمند دارو با عوارض جانبی کم‌تر میتوان استفاده کرد. &nbsp;استفاده از انواع سیستمهای نانویی در بهبود روند بیماری، افزایش سرعت تشخیص، کاهش سمیت داروها، افزایش اثرات داروها در درمان سرطان‌ها و بیماریهای مختلف کاربرد زیادی دارد.</span></span></span> <span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f"></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">نتی</span></span></span></b><b><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">جه</span></span></span></b><b><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f"> گیری</span></span></span></b><b><span lang="AR-SA" style="font-size:16.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">:</span></span></span></b><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f"> توسعه فناوری نانو </span></span></span><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">می تواند </span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">منجر به درمان های</span></span></span><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f"> دقیق، هدفمند و تشخیص سریعتر </span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f">انواع بیماریها‌ گردد.</span></span></span><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f"></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f"></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:10%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:#1f1f1f"></span></span></span></span></span></span></span></span></span></span></div> <p><span style="font-size:12pt"><span style="background:white"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">Introduction:</span></span></b> <span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">This</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> article</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> investigates</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> the use of nanoparticles and their types in the transfer of drugs and genes </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">for diagnosing and treating</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> various diseases.</span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="background:white"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">Methods:</span></span></b> <span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">A</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> review study was </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">conducted by searching</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> PubMed, Ovid, Google Scholar, and Web of Science databases. Two thousand original and review </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">articles </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">in English with full text were selected </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">through</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> direct content analysis</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">, and </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">one hundred articles were studied and reviewed.</span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="background:white"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">Results:</span></span></b><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> The findings </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">indicate</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> that nanoparticles can </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">facilitate</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> gene and drug transfer, </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">expedite</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> tumor diagnosis, and </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">enable </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">targeted drug </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">delivery</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> with </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">fewer</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> side effects. The use of various nanosystems is </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">beneficial for</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> improving disease </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">processes, accelerating</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> diagnosis, reducing </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">drug</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> toxicity, and </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">enhancing</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> treatment </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">efficacy for</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> cancers and </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">other</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> diseases.</span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="background:white"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">Conclusion:</span></span></b> <span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">Advancements in </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">nanotechnology </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">contribute</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> to </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">more precise</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">, targeted treatments and </span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414">quicker</span></span><span lang="en-UG" new="" roman="" style="font-family:" times=""><span style="color:#131414"> diagnosis of various diseases.</span></span></span></span></span></span></span></span></p> نانوذرات, انتقال دارو, انتقال ژن, تشخیص تومور, دارورسانی هدفمند Nanoparticles, Drug transfer, Gene transfer, Tumor diagnosis, Targeted drug delivery 301 312 http://aums.abzums.ac.ir/browse.php?a_code=A-10-622-7&slc_lang=fa&sid=1 Fatemeh Mansouri فاطمه منصوری mansouri1600@hotmail.com 100319475328460013694 0009-0006-7639-7843 Yes Department of Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran گروه ژنتیک و ایمونولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران