Alborz University Medical Journal
نشریه علمی پژوهشی دانشگاه علوم پزشکی البرز
aumj
Medical Sciences
http://aums.abzums.ac.ir
1
admin
2322-3839
2588-3046
10.61186/aums
fa
jalali
1400
2
1
gregorian
2021
5
1
10
2
online
1
fulltext
fa
مقایسه سطح سرمی فلزات سنگین (سرب، مس، روی و کادمیوم ( در بیماران مبتلا به سرطان معده با افراد غیر مبتلا به سرطان بستری در بیمارستان ولیعصر زنجان در سال 1397
Comparison of Serum Concentration of Lead, Copper, Zinc and Cadmium in Gastric Adenocarcinoma and Non-cancerous Patients in Valiasr Hospital of Zanjan in 1397
تخصصي
Special
پژوهشي
Research
<strong><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">زمینه و هدف</span></span></strong><span dir="LTR"> :</span><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سرطان</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">معده</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">یکی</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">از</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مهم</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">ترین</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">و</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">دومین</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">عامل</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مرگ</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">ناشی</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">از</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سرطان</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">در</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">دنیاست. ارتباط فلزات</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سنگین</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">با</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">برخی</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">از</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سرطان</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">ها</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">اثبات</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شده</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">ولی</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">ارتباط</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">این</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">فلزات</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">با</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">آدنوکارسینوم</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">معده</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">هنوز</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">به</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">طور کامل</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شناخته</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">نشده</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">است</span></span><span dir="LTR">.</span><span style="font-family:B Lotus;"><span style="font-size:10.0pt;"> در</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">این</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مطالعه</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سطح</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سرمی</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">4</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">فلز</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سنگین</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شامل</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سرب،</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">روی،</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مس</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">و</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">کادمیوم</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">در بیماران</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مبتلا</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">به</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">آدنوکارسینوم</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">معده</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">با</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;"> گروه کنترل مقایسه</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شده</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">است</span></span><span dir="LTR">.</span><br>
<strong><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مواد و روش<span style="color:black;">ها</span></span></span></strong><span dir="LTR"><span style="color:black;"> :</span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">در</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مجموع</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">114</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">نفر</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شامل</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">60</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بیمار</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">که</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">از</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بیماران</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بستری</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">در</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بخش</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">آنکولوژی</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بیمارستان</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">ولیعصر بودند</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">و</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">تشخیص</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">آدنوکارسینوم</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">معده</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">برای</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">آنان</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مسجل</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شده</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بود</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">و</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">54</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شاهد</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">که</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">از</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بیماران</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بستری</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">در</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بخش</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">چشم یا</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سایر</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بخش</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">های</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">غیرمرتبط</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بیمارستان</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">ولیعصر(عج)</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بودند، در</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">این</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مطالعه</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شرکت</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">کردند.</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">پس</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">از</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">اخذ خون</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">از</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شرکت</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">کنندگان</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">و</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">آماده</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سازی</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">نمونه</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">ها،</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">غلظت</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سرمی</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">4</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">فلز</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سنگین</span></span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شامل</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سرب،</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">روی،</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مس</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">و</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">کادمیوم با</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">استفاده</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">از</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">روش</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">پلاروگرافی</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">اندازه</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">گیری</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شد</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">و</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">نتایج</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">حاصل</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">از</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">آن</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">وارد</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">نرم</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">افزار</span></span><span dir="LTR"> SPSS </span><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شد</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">و</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مورد</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">آنالیز</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">قرار گرفت</span></span><span dir="LTR">.</span><br>
<strong><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">یافتهها</span></span></strong><strong><span dir="LTR">:</span></strong><span style="font-family:B Lotus;"><span style="font-size:10.0pt;"> در</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">این</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مطالعه</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">میانگین</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سطح</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سرمی</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مس</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">در</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بیماران مبتلا به آدنوکارسینوم معده </span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">به</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">طور</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">معناداری</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بالاتر</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">از</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">گروه شاهد</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بود (</span></span><span dir="LTR"> P-Value=0.04</span><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">)</span></span><span dir="LTR">.</span><span style="font-family:B Lotus;"><span style="font-size:10.0pt;"> اختلاف</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سطح</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سرمی</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سه</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">فلز</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">دیگر</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">در</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">افراد</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بیمار</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">و</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شاهد</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">به</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">لحاظ</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">آماری</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">معنادار</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;"> نبود،</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">هرچند</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">که</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">میانگین سطح</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سرمی</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">روی و مس</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">در</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">گروه</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بیماران</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بالاتر</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">از</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">افراد</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">سالم</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;"> بود.</span></span><br>
<strong><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">نتیجهگیری</span></span></strong><strong><span dir="LTR"> :</span></strong><span style="font-family:B Lotus;"><span style="font-size:10.0pt;">با</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">توجه</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">به</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">این</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مطالعه میتوان</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مس</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">را</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">به</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">عنوان</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">یک</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">کارسینوژن</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">احتمالی</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">درآدنوکارسینوم</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">معده</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">در</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">نظر</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">گرفت</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">اما</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">برای</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">تعیین</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">اثر</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">قطعی</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">این</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">فلزات</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">نیاز</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">به</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مطالعات</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">با</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">تعداد</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شرکت</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">کنندگان بیشتر میباشد. ضمنا</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">باتوجه</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">به</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">افزایش</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">تمایل مردم</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">نسبت</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">به</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">استفاده</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">از</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">ظروف</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مسی،</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">باید</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">هشدارهای</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">لازم</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">به</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">لحاظ</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">احتمال</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">کارسینوژن</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">بودن</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">مس</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">به</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">جامعه داده</span></span> <span style="font-family:B Lotus;"><span style="font-size:10.0pt;">شود</span></span><span dir="LTR">.</span><span style="font-family:B Lotus;"><span style="font-size:10.0pt;"></span></span>
<strong>Back ground:</strong> Gastric cancer is an important, prevalant and second most fatal cancer in the world. Previous studies show heavy metals have various roles in human health. Heavy metals are known to be associated with various cancers but their function in gastric adenocarcinoma is unclear. In this study we examined serum level of these metals in gastric adenocarcinoma patients compared to control group.<span dir="RTL"></span><br>
<strong>Method</strong>: In total, 114 subjects (54 controls and 60 cancer patients) were included in this study. We took blood samples from 60 known cases of gastric adenocarcinoma hospitalized in oncology Ward of Valiaasr Hospital and 53 none cancerous patients hospitalized in other wards of the Valiasr hospital, as control group. After sample preparation, serum concentration of Zinc, Cadmium, Lead and Copper were determined by polarography and the obtained data were analyzed by SPSS software.<span dir="RTL"></span><br>
<strong>Results</strong>: Serum level of Copper was significantly higher in patients with gastric adenocarcinoma compared to control group (P-Vlue= 0.04). No significant differences were found in serum level of zinc, lead and cadmium in gastric adenocarcinoma patients compared to control group (P-Value > 0.05), however the mean concentration of zinc and Lead were higher in cancerous patients.<span dir="RTL"></span><br>
<strong>Conclusion</strong>: Findings in this study appear to support that Copper overload may be risk factor of Gastric Adenocarcinoma but to find out the exact roles of theses heavy metals, more extended studies are needed. Recently, tendency to use copper containing dishes has been increased in our society, so necessary warnings should be given to the community as to the possible carcinogenicity of copper.
آدنوکارسینوم معده, روی, سرب, کادمیوم, مس
Gastric Adenocarcinoma, Zinc, Lead, Cadmium, Copper
165
172
http://aums.abzums.ac.ir/browse.php?a_code=A-10-1-281&slc_lang=fa&sid=1
Sattar
Jafari
ستار
جعفری
10031947532846009174
10031947532846009174
No
Gastroenterologist, Department of gastroenterology and hepatology, Valiasr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
فوق تخصص گوارش وکبد، دپارتمان گوارش و کبد، بیمارستان ولیعصر(عج)، دانشگاه علوم پزشکی زنجان، زنجان، ایران
Mehran
Mohseni
مهران
محسنی
10031947532846009175
10031947532846009175
No
Sciences, Zanjan, Iran 2 Department of Food and Drug Control, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
دپارتمان غذا و دارو، دانشکده داروسازی، دانشگاه علوم پزشکی زنجان، زنجان، ایران
Saeideh
Mazloomzadeh
سعیده
مظلومزاده
10031947532846009176
10031947532846009176
No
Social Determinants of Health Research center, Valiasr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
مرکز تحقیقات عوامل اجتماعی موثر بر سلامت، دانشگاه علوم پزشکی زنجان، زنجان، ایران
Saeed
Rezaei
سعید
رضائی
sz.rezaei32@gmail.com
10031947532846009177
10031947532846009177
Yes
Resident of Radiation Oncology, Department of Radiation Oncology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
رزیدنت رادیوانکولوژی، دپارتمان رادیوانکولوژی، بیمارستان امام خمینی(ره)، دانشگاه علوم پزشکی تهران، تهران، ایران