TY - JOUR T1 - The Protective Effects of Aqueous Extract of Glycyrrhiza Glabra Root Against Liver-related Biochemical Factors Changes Induced by Thioacetamide in Male Rats TT - اثرات حفاظتی عصاره آبی ریشه شیرین بیان (Glycyrrhiza glabra) برعلیه تغییرات فاکتورهای بیوشیمیایی مرتبط با کبد القاء شده توسط تیواستامید در موشهای صحرایی نر JF - Alborz-Health JO - Alborz-Health VL - 5 IS - 4 UR - http://aums.abzums.ac.ir/article-1-508-en.html Y1 - 2016 SP - 242 EP - 248 KW - Glycyrrhiza Glabra Root KW - Thioacetamide KW - Biochemical Factors KW - Male Rats N2 - Background: Thioacetamide is a liver toxin that causes centrilobular necrosis. In this study, the protective effect of aqueous extract of Glycyrrhiza glabra root against liver-related biochemical factors changes induced by thioacetamide in male rats was investigated. Materials and Methods: 35 male rats were divided into 5 groups of 7 : control group; sham group: receiving a single dose of 150mg/kg thioacetamide intraperitoneally; experimental groups 1 and 2 and 3: they received the aqueous extract of Glycyrrhiza glabra root at the doses of 100,200,300mg/kg daily orally during 3 months respectively and then a single dose of thioacetamide at 150 mg/kg as intraperitoneal injection . The serum levels of albumin, bilirubin and total protein were measured. Results: The mean of body weight in all experimental groups receiving aqueous extract of Glycyrrhiza glabra root and thioacetamide did not show significant changes compared to the group receiving thioacetamide. The mean levels of serum bilirubin in all experimental groups receiving aqueous extract of Glycyrrhiza glabra root and thioacetamide did not show significant changes compared to the group receiving thioacetamide. The mean of serum albumin concentration in all experimental groups receiving aqueous extract of Glycyrrhiza glabra root and thioacetamide decreased significantly compared to the group receiving thioacetamide. The mean of serum total protein concentration in experimental groups receiving aqueous extract of Glycyrrhiza glabra root and thioacetamide did not show significant changes compared to the group receiving thioacetamide( p<0. 05). Conclusion: The results of this study showed that the aqueous extract of Glycyrrhiza glabra root had protective effects against liver-related biochemical factors changes induced by thioacetamide in male rats. M3 10.18869/acadpub.aums.5.4.242 ER -