Showing 5 results for Stem Cells
Fatemeh Mansouri,
Volume 7, Issue 3 (8-2018)
Abstract
Stem cells as natural cells exist in embryonic and adult tissues. Recent studies have begun to prove the strong and powerful role of stem cells in the field of treatment. Stem cells have the potential for self-renewal and differentiation into specific types of somatic cells. Their ability to produce new cells in medicine, drug discovery, cell therapy and research is very important. In the past decades, many efforts have been made to find safe, low-cost methods and progress stem cell culture. The purpose of this review article is to: 1) explain the application of stem cells in medicine, drug discovery, modeling of disease and toxicology studies. 2) A summary of recent advances in stem cell technology, the advantages and disadvantages of the most commonly used culture methods.
The result of this discussion shows that the use of new culture methods can be effective in the optimal use of stem cells.
Maedeh Mohammad Salehi, Ahmad Reza Farmani, Jafar Ai,
Volume 10, Issue 2 (5-2021)
Abstract
The term "electromagnetic fields" (EMF) is a combination of electric and magnetic fields as a diagnostic method as well as a therapeutic tool with many advantages such as ease of operation and painlessness, very controllable, which today has found wide application in regenerative medicine and also cancer treatment.
In addition to organs such as nerves, hearts, and bones that have an electrical function, the presence of electrically charged particles inside the cells creates an internal electromagnetic field. This field can be affected by the external electromagnetic field and cause therapeutic effects. Its therapeutic effects relate to the applications of the electromagnetic field as a stimulus to induce various biological effects on cells, such as altering cell proliferation, differentiation, cell cycle, apoptosis, DNA proliferation, cytokine expression, and more. Also, combination therapy by the electromagnetic field, along with other physical therapies such as radiotherapy and even systemic therapy such as chemotherapy, are the most important approaches to using the electromagnetic field in the treatment of cancer.
Subsequently, Electromagnetic fields can lead to the proliferation and differentiation of stem cells and the modulation of the immune system, which plays an important role in the treatment of inflammatory disease and regenerative medicine treatments. Also, this field can create new horizons in cancer treatment due to its many advantages such as being a non-invasive, selective function, and ease of using and as well as affordability.
Parvaneh Karimpour Azar , Sudabeh Shapouri, Hajar Zarei, Ahmad Saeedi,
Volume 10, Issue 2 (5-2021)
Abstract
The term "electromagnetic fields" (EMF) is a combination of electric and magnetic fields as a diagnostic method as well as a therapeutic tool with many advantages such as ease of operation and painlessness, very controllable, which today has found wide application in regenerative medicine and also cancer treatment.
In addition to organs such as nerves, hearts, and bones that have an electrical function, the presence of electrically charged particles inside the cells creates an internal electromagnetic field. This field can be affected by the external electromagnetic field and cause therapeutic effects. Its therapeutic effects relate to the applications of the electromagnetic field as a stimulus to induce various biological effects on cells, such as altering cell proliferation, differentiation, cell cycle, apoptosis, DNA proliferation, cytokine expression, and more. Also, combination therapy by the electromagnetic field, along with other physical therapies such as radiotherapy and even systemic therapy such as chemotherapy, are the most important approaches to using the electromagnetic field in the treatment of cancer.
Subsequently, Electromagnetic fields can lead to the proliferation and differentiation of stem cells and the modulation of the immune system, which plays an important role in the treatment of inflammatory disease and regenerative medicine treatments. Also, this field can create new horizons in cancer treatment due to its many advantages such as being a non-invasive, selective function, and ease of using and as well as affordability.
Fatemeh Mansouri ,
Volume 10, Issue 3 (9-2021)
Abstract
Mesenchymal stem cells are used to treat stroke and myocardial infarction in patients. Although they are fundamentally different from heart cells such as heart muscle cells, recent evidence suggests that injections of mesenchymal stem cells into the heart are mediated by the secretion of paracrine factors to restore heart function. Mesenchymal stem cells release all of the paracrine factors through membrane vesicles called exosomes. All biomolecules are assembled into exosomes that are regularly released from the donor cell. Also, exosomes bind to cellular receptors by the ligand-receptor reaction. Therefore, exosomes can secrete biological molecules such as proteins, RNAs and microRNAs. Stem cell-derived exosomes can be successfully used in the treatment of cardiovascular disease, cancers and hypertension. The purpose of this paper is to investigate the components and changes in the content of exosomes in human cells that can be used as an effective treatment in the treatment of various cardiovascular diseases and other diseases. Futures clinical studies will require the effective use of exosomes in cardiovascular disease, based on the specific molecular structure of each individual in personalized medicine.
Fatemeh Mansouri, Ali Golchin,
Volume 10, Issue 4 (10-2021)
Abstract
Currently, the use of cell therapy is an effective treatment method in some types of diseases. The use of stem cells and somatic cells, due to the complete genetic similarity with individual cells, has led to the development of cell therapy methods. In recent years, significant advances have been made in the methods of culturing, isolating, and long-term cell maintenance. However, there are still problems and concerns related to their clinical use, the resolution of which requires more detailed studies in this area. One of these problems is genomic changes in cells that can affect the potential for differentiation of stem cells. Genetic abnormalities occur during successive cultures during the process of proliferation and differentiation, and can affect cell behavior and subsequent laboratory results. The aim of this study is to investigate the importance of chromosomal studies in cell therapy for the analysis of chromosomes and summarize the applications and limitations of these methods in the medical sciences.
Conclusion: The results of this discussion show that the use of different techniques of chromosomal studies can be considered in the final evaluation and obtaining confirmation of the accuracy of cellular products in treatment. Periodic and regular examinations of genomic stability in cells before their clinical use are essential.
