Alborz University

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Background: Thioacetamide causes kidney dysfunction. The present study was done to evaluate the protect effects of fish oil omega3 Supplements and aqueous extract of Glycyrrhiza glabra root on disorder of renal function induced by thioacetamide in male rats.

Materials and Methods: 63 male rats were divided into 9 groups of 7 : The control group, The sham group receiving 0. 4ml/kg olive oil as the solvent of Fish oil Omega-3 supplements, the thioacetamide group interperitonealy receiving a dose of 150 mg/kg thioacetamide at the end of the experiment, the experimental groups 1, 2 and 3 orally receiving a daily dose of 100, 200 and 300 mg/kg fish oil omega-3 supplements respectively for 3 month followed by an inter peritoneal dose of 150 mg/kg thioacetamide at the end of the experiment. experimental groups 4 and 5 and 6: they received the aqueous extract of Glycyrrhiza glabra root at the doses of 100,200,300mg/kg daily orally during 3 months respectively and then a single dose of thioacetamide at 150 mg/kg as interperitoneal injection. The levels of serum creatinine, BUN, sodium and potassium were measured. The pathological changes of tissue samples of the kidneys were studied after hematoxylin-eosin staining.

Results: The mean serum levels of potassium in the second experimental group significantly decreased compared to the group receiving thioacetamide . The mean serum sodium in all experimental groups decreased significantly compared to the group receiving thioacetamide. No significant changes were observed in the mean serum levels of FBS, BUN and creatinine in all experimental groups compared to the group receiving thioacetamide. Pretreatment with the aqueous extract of Glycyrrhiza glabra root at all doses let to increased the serum level of BUN comparing with thioacetamide group but there was no significant difference . Pretreatment with the aqueous extract of Glycyrrhiza glabra root at all doses let to significant reduced the serum levels of potassium and sodium comparing with thioacetamide group. Pretreatment with 300 mg/kg of aqueous extract of Glycyrrhiza glabra root let to significant reduced the serum level of creatinine comparing with thioacetamide group. All the experimental groups improved renal histological changes induced by thioacetamide and these protective effects were dose-dependent. (p≤0/05)

Coclusion: The results of this study showed the protective effect of omega-3 fish oil supplement and aqueous extract of Glycyrrhiza glabra root on disorder of renal function induced by thioacetamide in male rats. 

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Background: This study compared the effect of Voluven and Ringer solution in cardiopulmonary bypass on the bleeding after the surgery and renal function in coronary artery bypass graft surgeries.
Methods: Two types of prime solution including ringer - as Crystalloid- and Voluven were used in two groups and compared in terms of bleeding and renal function during the first 24 hours after the surgery in intensive care unit (ICU) cardiac surgery.
Results: Amount of a 24-hour drainage was not statistically different (P > 0.05). There was not any significant difference between groups regarding urinary output in two time periods, pump time and during the first 24 hours after the patient’s entry to ICU. The mean of partial thromboplastin time postop in experiment and control groups was significantly different (P > 0.05). Plasma level of Bun-Cr  , sodium, Potassium, hemoglobin, hematocrit, BT, PT and INR Platelets was not significantly different during the first 24 hours after the surgery (P > 0.05). There was a significant difference between the two groups in terms of a need for blood transfusion   during the surgery and first 24 hours after the surgery (Ringer 1.70 ± 0.9, Vovuven 1.07 ± 1.1) (P = 0.019). There was not a significant difference between two groups in terms of urinary protein secretion during the first 24 hours after the surgery (P = 0.08).
Conclusions: It can be concluded that using Voluven as prime solution in comparison to lactate, in our study  did not cause any significant difference in bleeding after the surgery and there was not so much need for blood injection in these patients