Mehrnoush Ghavami, Mehrdad Shariati, Mokhtar Mokhtari, Saeed Khatamsaz, Davood Moghadamnia,
Volume 12, Issue 3 (9-2023)
Abstract
Background: Cadmium chloride causes lipid dysfunction. In this study, the protective effects of hydroalcoholic extract of Passiflora caerulea aerial parts against lipid dysfunction induced by cadmium chloride in male rats were investigated.
Methods: In this experimental study, 54 adult male wistar rats were divided into 6 groups of 9. The control group, The sham group received 2 ml / distilled water as solvent. The negative control group received 2 mg / kg cadmium chloride intraperitoneally for 21 days. Experimental 1, 2 and 3 groups: respectively, received 2 mg / kg cadmium chloride intraperitoneally for 21 days and then 150,300 and 450 mg / kg hydroalcoholic extracts of aerial parts of Passiflora caerulea intraperitoneally for 30 days. Blood samples were taken from all animals at the end of the experiment. Blood samples were taken to measure levels of HDL, LDL, total cholesterol and triglycerides. Data were analyzed according to SPSS18 program, analysis of variance (ANOVA) and Tukey tests.
Results: The mean serum concentrations of total cholesterol, triglyceride and low-density lipoprotein (LDL) in all experimental groups compared to the negative control group showed a significant decrease. Mean serum high-density lipoproteins (HDL) concentration in experimental 2 and 3 groups showed a significant increase compared to the negative control group (P <0.05).
Conclusion: The hydroalcoholic extract of the aerial parts of Passiflora caerulea probably corrects the lipid dysfunction induced by cadmium chloride in male rats.
