1 L. Payahoo, 2 M. Mobasseri, 3 Y. Khaje Bishak, 4 M. Asghari Jafarabadi, 5 A. Ostadrahimi,
Volume 2, Issue 1 (1-2013)
Abstract
Background: Obesity as one of the most important health problems in the world, involved in the incidence of many chronic disorders. Obese individuals have lower level of vitamins and minerals such as zinc. Zinc is one of trace elements involved in synthesis, storage, release and action of insulin and in pathway of fat and carbohydrate metabolism. This study conducted to assay the effects of zinc supplementation on the insulin resistance, lipid profiles and blood sugar in obese people. Methods: This randomized, double blind, placebo-controlled clinical trial was performed on 60 obese people (BMI >30 kg/m2). Duration of intervention was one month. The eligible participants divided in two equal groups: intervention and placebo, randomly. Intervention group received a 30mg/d zinc pill and placebo group received 30mg/d starch. The concentration of serum insulin, insulin resistance index (HOMA-IR), lipid profiles and fasting blood glucose were determined in onset and at the end of study. Results: Zinc supplementation resulted in a significant reduction in serum insulin concentration, insulin resistance index and serum triglyceride at the end of intervention (p<0.05). However, these results were not significant in placebo group. In contrast, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting blood, sugar (FBS) did not change significantly. Conclusion: Zinc supplement had positive effect on the reduction of insulin concentration and insulin resistance index. More studies with longer period of intervention suggested for disclose more mechanisms in this field.
L. Kamaei, H. Fathi Moghaddam , M. Mokhtari , D. Moghadamnia,
Volume 6, Issue 1 (12-2016)
Abstract
Background: Diabetes Mellitus is a important diseases. In the traditional and modern medicine different trap tics have been recommend medicine for diabetes Mellitus. We studied effects of Avicenna marina leaf and fruit hydro alcoholic extract in the diabetic rat by streptozotocin.
Materials and Methods: In this experimental study; 45 male rats were divided into 9 groups of 5. Sham group; animals were fed with a normal diet. The test groups received intraperitoneal injection of 60mg/kg streptozotocin for induction of diabetes. Diabeties groups were further sub grouped into; diabetes sham, positive sham (diabetes + 0.9% normal saline) and 6 groups treated orally with hydro alcoholic extract of Avicenna marina leaf and fruit (30, 60, 120 mg/kg daily for three consecutive days). Twenty-four hours after the last treatment rats, blood samples were collected from heart for determining the blood glucose and insulin concentration levels using glucose oxidase and enzyme-linked immunosorbent assay(ELISA) methods respectively.
Results: Our results indicated that Avicenna marina leaf and fruit hydro alcoholic extract in all doses significant decrease in the serum glucose level of diabetic test rats compared to treated diabetic sham rats. 120mg/kg of Avicenna marina leaf hydro alcoholic extract significant increase in the serum insulin level of diabetic test rats compared to treated diabetic sham rats. 60mg/kg of Avicenna marina fruit hydro alcoholic extract significant increase in the serum insulin level of diabetic test rats compared to treated diabetic sham rats(P<0. 05) .
Conclusion: Avicenna marina leaf and fruit hydro alcoholic extract can significantly decrease the blood glucose in streptozotocin-induced diabetic male rats.
