Showing 3 results for Omidi
Mitra Omidi, Farzaneh Firoozeh, Mahmood Saffari, Hossein Sedaghat,
Volume 10, Issue 1 (Winter 2021)
Abstract
Background and Aim: Increased prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and treatment of infections due to these resistant strains is one of the most important health challenges. In this study, antimicrobial resistance patterns of Staphylococcus aureus isolates from patients were determined to commonly prescribed and last-resort antibiotics, and methicillin-resistant Staphylococcus aureus strains were isolated according to detection of mecA and femA genes.
Materials and Methods: This research was done on 146 Staphylococcus aureus isolates from hospitalized and outpatients who referred to Isfahan Hospitals and Shahid-Beheshti Hospital of Kashan from June 2017 to September 2018. Antimicrobial resistance patterns to common antibiotics were determined by disk diffusion method according to the Clinical and Laboratory Standards Institute (CLSI) 2018 guidelines. Also Vancomycin minimum inhibitory concentration (MIC) of MRSA strains was determined using broth microdilution method. Isolation of MRSA strains were phenotypically done using cefoxitin disk and for confirmation mecA and femA genes were detected in these strains.
Results: From 146 collected clinical samples, frequencies of MRSA and methicillin-susceptible Staphylococcus aureus (MSSA) were 24 (16.4%) and 122 (83.6%) respectively. The most resistance rate were detected to erythromycin 44 (30.1%) and vancomycin resistance was not seen among the S. aureus isolates, whereas linezolid resistance was 2/1 percent. In molecular study using PCR method, all MRSA strains carried mecA and femA genes.
Conclusion: Current study showed that the frequency of MRSA among clinical samples isolated from Isfahan and Kashan Hospitals is relatively high. Also the presence of resistance to new and important antibiotics as last resort treatment is considered a serious alarm.
Azade Al-Sadat Mirrajaee, Marjan Vakili, Reza Arjmand, Farzaneh Firoozeh, Narges Omidinia, Mohammad Zibaei, Malihe Farid,
Volume 12, Issue 3 (Summer 2023)
Abstract
Background and Aim: Urinary tract infections (UTI) are one of the most common bacterial infections of childhood. Uropathogenic Escherichia coli (UPEC) strains, with the ability to successfully colonize the urinary tract, are recognized as the main cause of UTI. The aim of this study is to investigate UPEC strains in children with UTI in Karaj city during 1400-1401.
Materials and Methods: In current study, 146 UPEC isolates were collected from children with UTI referred to Karaj Hospitals, Alborz province during January to August 2022. The identification of isolates as UPEC strains was confirmed using standard microbiological methods and biochemical tests. PCR method and amplification of 16SrRNA gene were used for confirmation of diagnosis. Statistical data analysis was performed with SPSS software version 23. Statistical comparison between groups was done using chi-square and Fisher's exact tests.
Results: The results showed that out of 146 children suffering from urinary tract infections caused by UPEC strains during the study period, 30 (20.5%) were male and 116 (79.5%) were female. In addition, 16 (11.0%) had underlying kidney disease and 130 (89.0%) had no underlying kidney disease.
Conclusion: The present study showed that urinary infection with UPEC strains constitutes more than half of the cases of UTIs in children over one-year-old in Alborz province. In addition, the infection is almost 3.9-times more in girls over one year old than in boys. Although male children with underlying kidney disease are more likely to get UTI with the UPEC strains than female children with underlying kidney disease.
Fatemeh Omidi, Shahram Sayyadi, Mohammad Mahdi Omidian, Roya Vaziri-Harami, Parisa Delkash, Amir Behnam Kharazmi,
Volume 14, Issue 3 (5-2025)
Abstract
Introduction: Rheumatoid arthritis is a chronic inflammatory disease that predominantly affects the joints and can significantly impact the quality of life of patients. Tofacitinib is recognized as a key medication in managing this condition. However, concerns about the potential side effects of this drug, especially its impact on cardiovascular health, still exist.
Methods: International databases including PubMed, Embase, and Cochrane Central were searched for relevant articles. The quality of the studies was assessed using the Cochrane risk of bias assessment tool. Data were statistically analyzed using a random-effects model and the CMA software version 3.
Results: This study, based on data from five trials involving 3,111 rheumatoid arthritis patients, investigated the relationship between Tofacitinib at 5 mg and 10 mg doses and cardiovascular events. In the 5 mg Tofacitinib group, 8 out of 1,897 patients experienced cardiovascular events (odds ratio of 2.95 with a 95% confidence interval from 0.5 to 17.1). In the 10 mg Tofacitinib group, only 4 out of 1,895 patients reported these events (odds ratio of 1.83 with a 95% confidence interval ranging from 0.3 to 9.3).
Conclusion: Tofacitinib is recognized as an effective drug in controlling the symptoms of rheumatoid arthritis. However, our results indicate that the use of this drug may be associated with an increased risk of cardiovascular events. Although these differences were not statistically significant, they emphasize the importance of closer monitoring of patients taking Tofacitinib. Clinical decisions should consider the risk of cardiovascular events, and conducting intervention studies with larger sample sizes and longer follow-ups is essential.
