Showing 3 results for Ghavam
Mansureh Ghavam, Hossein Azarnivand, Fatemeh Sefidkon, Ali Tavili,
Volume 9, Issue 4 (Autumn 2020)
Abstract
Achillea millefolium L. is one of the most famous medicinal herbs that has been used extensively in ancient medicine for the treatment of diseases in general and wounds and burns in particular. This plant has many subspecies that different compounds of monoterpene and sesquiterpene are found in its essential oil. The purpose of this study was to analyze and compare the yields and essential oil compositions of two subspecies of Achillea millefolium subsp. millefolium and Achillea millefolium subsp. elbursensis with an economical usability approach in the pharmaceutical and medical sciences. For this purpose, two subspecies were collected from two subspecies in flower and leaf mountain range in July and flowering with three replications. Essential oil extraction was performed by Clevenger method and essential oils were identified by mass spectrometry chromatography (GC / MS). The results of analysis of variance showed that there was a significant difference between the two subspecies in flower and leaf essential oil yield at 1% level and the highest yield belonged to Alborz flower. Also, comparison of the essential oils and essential oils of Alborz aquatic leaves showed that the major part of the essential oils of both organs was chamazolene and was always higher in flower (79.3%) than in leaves (69.2%). However, in the Hibernians, the composition of 1 and 8 cineol was 14.4% in flowers and 5.6% in leaves. Thus, Alborz subspecies can be a unique natural economic resource for the pharmaceutical industry in the production of comazolene-containing drugs such as anti-inflammatory drugs and skin diseases and a subspecies of thousands of leaves grown in Alborz Mountains for extraction of 1 and 8 cineols in various medical and pharmaceutical applications.
Mehrnosh Ghavami, Mehrdad Shariati, Mokhtar Mokhtari, Saeed Khatamsaz, Davood Moghadamnia,
Volume 12, Issue 2 (Spring 2023)
Abstract
Background: Cadmium chloride causes liver dysfunction. In the present study, the protective effects of hydroalcoholic extract of aerial parts of Alcea rosea against changes in biochemical factors and hepatic tissue induced by cadmium chloride in male Males were investigated.
Methods: In this experimental study, 56 adult male Wistar rats weighing approximately 200±10 g were divided into 6 groups of 9. The control group, The sham group 1 received 0.2 ml distilled water as solvent. The sham group 2 received 2 mg/ kg of cadmium chloride intraperitoneally for 21 days. Experimental groups 1, 2 and 3: 2 mg / kg cadmium chloride intraperitoneally for 21 days and then 450 and 300,150 mg / kg hydroalcoholic extracts of aerial parts of Alcea rosea received intraperitoneally for 30 days. At the end of the experiment, the body weight and liver weight of the animals were measured. Blood samples were taken to measure albumin, bilirubin and total protein levels. Liver tissue samples were studied pathologically after hematoxylin-eosin staining.
Results: The mean body weight in all experimental groups did not show significant changes compared to the sham group2. The mean liver weight in all experimental groups showed a significant increase compared to the sham group2. Mean serum bilirubin concentration in all experimental groups showed a significant decrease compared to the sham group2. The mean serum albumin concentration in the experimental group receiving 3 showed a significant increase compared to the sham group2. Mean serum albumin and total protein concentrations in the experimental group receiving 2 showed a significant increase compared to the sham group2 (P <0.05). In all experimental groups, the improvement of hepatic tissue changes induced by cadmium chloride was dose-dependent.
Conclusion: It is possible that the hydroalcoholic extract of the aerial parts of Alcea rosea improves the changes in biochemical factors and hepatic tissue induced by cadmium chloride in male rats.
Mehrnoush Ghavami, Mehrdad Shariati, Mokhtar Mokhtari, Saeed Khatamsaz, Davood Moghadamnia,
Volume 12, Issue 3 (Summer 2023)
Abstract
Background: Cadmium chloride causes lipid dysfunction. In this study, the protective effects of hydroalcoholic extract of Passiflora caerulea aerial parts against lipid dysfunction induced by cadmium chloride in male rats were investigated.
Methods: In this experimental study, 54 adult male wistar rats were divided into 6 groups of 9. The control group, The sham group received 2 ml / distilled water as solvent. The negative control group received 2 mg / kg cadmium chloride intraperitoneally for 21 days. Experimental 1, 2 and 3 groups: respectively, received 2 mg / kg cadmium chloride intraperitoneally for 21 days and then 150,300 and 450 mg / kg hydroalcoholic extracts of aerial parts of Passiflora caerulea intraperitoneally for 30 days. Blood samples were taken from all animals at the end of the experiment. Blood samples were taken to measure levels of HDL, LDL, total cholesterol and triglycerides. Data were analyzed according to SPSS18 program, analysis of variance (ANOVA) and Tukey tests.
Results: The mean serum concentrations of total cholesterol, triglyceride and low-density lipoprotein (LDL) in all experimental groups compared to the negative control group showed a significant decrease. Mean serum high-density lipoproteins (HDL) concentration in experimental 2 and 3 groups showed a significant increase compared to the negative control group (P <0.05).
Conclusion: The hydroalcoholic extract of the aerial parts of Passiflora caerulea probably corrects the lipid dysfunction induced by cadmium chloride in male rats.
