Showing 5 results for Forghani
Elahe Dolatshahi, Mohamad Moin Forghani Ramandi,
Volume 9, Issue 2 (Vol.9, No.2, 2020 2020)
Abstract
IgG4 related disease is fibro-inflammatory condition characterized by infiltration and increased levels of G4 immunoglobulin, multi-organ involvement and periorbital swelling. It is more common among men especially in middle to old ages. The diagnosis should be confirmed with histopathology. The diagnostic three important features of disease are lymphoplasmacytic infiltration, storiform fibrosis, and obliterative phlebitis. Treatment is Commonly based on corticosteroids.
Somayeh Khoramian Tusi, Rasoul Forghani, Mitra Rahim Zadeh, Behnam Zeynali,
Volume 9, Issue 4 ( S1, Summer 2020 2020)
Abstract
Background: DMFT index and Oral Hygiene Index Simplified (OHI-S) are diagnostic indicators of oral health. The aim of this study was to determine the DMFT and OHI_S indexes at Alborz University of Medical Sciences in 2018.
Materials and Methods: This cross-sectional descriptive-analytic study was conducted among 381 students of Alborz University of Medical Sciences during the academic year of 2018. The numbers of decayed, filled and missing teeth were recorded. Students were also evaluated for the debris and calculus index.
Results: In this study, 38.1% of the subjects were males with an average age of 20.51±2.01 years old and 61.9% were females with an average age of 20.59±2.2 years old. The average of DMFT index in students was 6.48±3.4, which the highest DMFT index was related to the number of decayed teeth. The mean OHI-S index of the subjects was 0.66±0.63, which 84.3% of students had a good status, 15.5% moderate and 0.2% had a bad condition. There was no significant difference between boys and girls regarding DMFT and OHI-S indexes (P>0.05). The relationship between the numbers of students' brushing was reversed with DMFT and OHI-S indexes, but this relationship was not statistically significant (P>0.05). There was a significant difference in DMFT and OHI-S indexes between students’ different educational fields.
Conclusion: The results of this study showed that the students were desirable condition in OHI-S index and relatively favorable in the DMFT index.
Sedigheh Yektamoghaddam, Mohammad Mahdi Forghanifard, Vajiheh Zarrinpour, Mojtaba Fathi,
Volume 12, Issue 2 (Spring 2023)
Abstract
Introduction: Gallstones are one of the most common gastrointestinal diseases because genetic factors have not been yet identified. The ABCB11 gene locates on chromosome 2 and generates the Bile Salt Output Pump (BSEP) in human encoding by creating gallstone. Our aim of in the present study was to investigate the relationship between liver biochemical factors and ABCB11 gene polymorphism with the risk of gallstone.
Materials and Methods: The study was performed recruiting 100 gallstone patients and 100 healthy individuals in Golsar Hospital, Rasht, in 1397. After sonography, subjects were divided into patients and healthy groups and the relationship between disease and ABCB11 gene polymorphism was examined by ARMS-PCR. Typically, 10 samples were sampled for the required sequencing results. Differences between the two groups were determined by statistical analysis.
Results: In the present SGOT study, SGPT level was elevated in patients in comparison with healthy individuals (P <0.05). The frequency of ABCB11 gene C allele between patient and healthy was 22.5% and 22% of the budget, respectively. There is no significant relationship between the frequency of alleles and genotypes in patients compared to healthy cases (P ˃ 0.05). Under these conditions, the frequency of TT, TC and CC genotypes among individuals over 60 years of age were 27, 21 and 3, respectively. There is no significant relationship between gender and age with disease (P /0 0.05). The mean age of patients over 60 years (P = 0.0) was significantly higher than healthy. People with homozygous TT genotype were more likely to develop the disease.
Discussion and Conclusion: The increased level of biochemical factors can predicts possibility of liver damage. The lack of correlation between ABCB11 and disease may be due to genetic differences between different races. Further studies with a larger group is essential.
Mohammad-Moien Forghani-Ramandi, Sayed-Hamidreza Mozhgani,
Volume 13, Issue 0 (Supplement, Winter 2024)
Abstract
Background: Adult T-cell leukemia/lymphoma (ATLL) is a cancer with a very poor prognosis. ATLL has four subgroups, acute, chronic, lymphoma, and smoldering, with very different prognoses. In this study, we tried to better understand the pathogenesis of ATLL and the differences between its subgroups by using gene expression data and bioinformatics methods.
Methods: Genes with altered expression were identified among different types of ATLL. In order to determine the key genes, the network of protein interactions between the resulting genes was constructed. After screening the hub genes based on the network centrality indices, the cell signaling pathways related to them were identified.
Results:Comparing the acute type with the chronic and silent types, the cell signaling pathways involved in regulating the function of the immune system are expressed differently. In comparison of acute and chronic type with healthy people, genes related to malignancy are involved. In comparing the silenced type with healthy individuals, the pathways related to infections are disrupted. In the secondary comparison, it was found that the genes related to cell proliferation and malignancy in the acute form were expressed more and the genes related to the immune system were less expressed in these patients than in the rest of the population.
Conclusion:It seems that manipulations by the virus resulting in immune escape and also in increased proliferation of infected cells have a decisive role in the occurrence of the aggressive type of the disease. Further investigations can lead to the development of new diagnostic methods, determining prognosis and even the detection of targets for gene therapy.
Mohammad-Moien Forghani-Ramandi, Arvin Najafi,
Volume 13, Issue 0 (Supplement, Winter 2024)
Abstract
Background: Diffuse large B-cell lymphoma is the most common invasive non-Hodgkin's lymphoma. There is a strong relationship between Helicobacter pylori infection and the occurrence of this malignancy. It has been seen that some patients with DLBCL in the early stages respond well to Helicobacter pylori eradication treatment, but others are resistant to it. Due to the lack of sufficient knowledge about the occurrence of this resistance, it is necessary to identify mechanisms of resistance.
Methods: The gene expression data of sensitive and resistant patients were obtained from GEO site. After determining the genes with altered expression, in order to identify the key genes, the protein interaction network was constructed and the important genes were filtered based on the network centrality indices. Finally, cellular signaling pathways associated with key genes were determined.
Results: CXCL8, EGFR, FN1, ICAM1, IL1B, TLR2, TLR4, TNF and VEGFA genes were identified as highly important genes according to the network analysis and the results obtained from the pathway enrichment analysis. Key genes showed a significant relationship with functions related to the regulation of immune cells activation.
Conclusion: The results obtained from this study show the significant role of cell functions related to surface receptors and also the regulation of immune cells activation in the occurrence of resistance to treatment. The genes and cellular pathways identified in this study can be used as therapeutic targets and biomarkers for diagnosis, determination of the appropriate treatment method for the patients and prognosis.
