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Fatemeh Moghaddam, Masoumeh Asle-Rousta,
Volume 7, Issue 2 (5-2018)
Abstract

Background: Summer savory- Satureja hortensis L. is from Lamiaceae family and has antioxidant, anti-inflammatory, anti-apoptotic properties. The purpose of this study is to investigate the effect of hydro-alcoholic extract of Summer Savory leaves on the level of LH, FSH and testosterone in male rats exposed to chronic immobilization stress.
Material and Methods: This study was conducted experimentally. 48 adult male Wistar rats were divided into 6 groups including: Control, Stress, Savory 200, Savory 400, Stress-Savory 200, and Stress-Savory 400. Groups 2, 5, and 6 were placed into restrainer for 6hours per day during 21 consecutive days and groups 3, 4, 5, and 6 were gavaged by hydro-alcoholic extract of Summer Savory with different doses of 200,400mg/kg during 21consecutive days. The level of LH, FSH and testosterone were measured by the end of period.
Results: Chronic Immobilization caused significant decrease in serum concentrations of LH (p<0.01), FSH (p<0.01), and testosterone (p<0.001) in stress group compared with the control group and taking both doses of plant extracts inhibited the above effect.
Conclusion: It is concluded that the Satureja hortensis extract may stimulates the hypothalamic-pituitary-gonadal axis and prevents stress-induced reproductive damages.
Leila Rajaian, Masoumeh Asle-Rousta,
Volume 13, Issue 4 (Autumn 2024)
Abstract

Background and purpose:  Chronic immobilization stress can damage the nervous system, leading to learning and memory disorders, anxiety, and depression. Parsley (Petroselinum crispum) is known for its antioxidant, anti-diabetic, anti-inflammatory, and hepatoprotective properties. This study investigates the effects of hydroalcoholic extract of parsley on learning, spatial memory, and anxiety behavior in adult male Wistar rats subjected to chronic immobility stress.
Materials and methods: Sixty rats were divided into six groups: control, stress, Parsley 1 (1 mg/kg), Parsley 2 (2 mg/kg), stress-parsley 1, and stress-parsley 2. For 21 consecutive days, rats were restrained for 6 hours daily to induce stress. Hydroalcoholic extracts of parsley were administered via gavage at doses of 1 and 2 mg/kg during this period. Spatial learning and memory were assessed using the Morris water maze, while anxiety behavior was evaluated with the elevated plus maze.
Results: In the Morris water maze, stress-parsley groups 1 and 2 showed a significant reduction in the time and distance traveled to reach the hidden platform compared to the stress group (p < 0.01 and p < 0.05, respectively). In the probe test, these groups spent a greater distance and time in the target quadrant compared to the stress group (stress-parsley group 1, p < 0.05; stress-parsley group 2, p < 0.01). Additionally, the elevated plus maze results indicated that the percentage of entries into the open arm and time spent in this arm were significantly higher in the stress-parsley groups compared to the stress group (p < 0.05).
Conclusion: Hydroalcoholic extract of parsley improved learning and spatial memory while reducing anxiety behavior in rats exposed to chronic immobility stress, suggesting its potential therapeutic effects for stress-induced disorders.


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