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Antiviral Effect Assay of Thymus Kotschyanus on HSV-1 Multiplication
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Malihe Farahani   |
| Deportment of Microbiology of Qom Branch, Islamic Azad University, Qom, Iran , ami.airia@gmail.com |
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Abstract: (8379 Views) |
Background: Nowadays, the treatment of viral diseases such as Herpes simplex virus type 1 with chemical drugs is one challenge of medical knowledge due to the appearance of drug resistance in the virus. So, the need is for new antiviral drugs. In this regard, we can use the medicinal application of plants which has been found in human life lots. In this study, antiviral effect of Thymus kotschyanus plant was investigated on HSV-1 multiplication.
Methods: Thymus kotschyanus plant was extracted with decoction method to obtain aqueous extract. This extract was screened for its cytotoxicity on Hep-2 cell line by CPE assay at concentrations 50-1000 μg/ml. Antiviral properties of the plant extract was determined by cytopathic effect inhibition assay at one, two and three hours after inoculation of HSV-1.
Results: Thymus kotschyanus plant had not toxic effect at nontoxic concentrations to use. Findings indicated most antiviral effect of plant extract after an hour of virus inoculation that decreased at two and three hours.
Conclusion: Thymus kotschyanus extract exhibited very well antiviral effect on HSV-1 at nontoxic concentrations to use. Further research is needed to find effect mechanism of this plant which be used in conformation of antiviral drugs. |
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| Keywords: Antiviral, Thymus kotschyanus, HSV-1 |
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Full-Text [PDF 280 kb]
(1898 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2018/01/10 | Accepted: 2018/01/10 | Published: 2018/01/10
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