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Halvani A, Rafatmagham S, Ghezelbash Z. Relationship between CT scan patterns and biopsy success rate and pathological findings of CT-guided lung biopsy in patients presenting with lung masses in 2023-2024. aumj 2026; 15 (3) : 1
URL: http://aums.abzums.ac.ir/article-1-2009-en.html
URL: http://aums.abzums.ac.ir/article-1-2009-en.html
1- Department of Internal Medicine, School of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran
2- Department of Internal Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran ,r.sareh2012@gmail.com
3- Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran
2- Department of Internal Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran ,
3- Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran
Abstract: (29 Views)
Introduction: Transthoracic needle aspiration biopsy is a reliable and accurate diagnostic procedure for the evaluation of benign and malignant thoracic lesions. Currently, computed tomography (CT) is the most widely used imaging modality for guiding percutaneous needle biopsy procedures of pulmonary lesions. However, several lesion-related factors may influence the diagnostic yield and pathological outcomes of CT-guided lung biopsy.
Methods: This descriptive cross-sectional study was conducted among patients with confirmed lung masses who were referred to Mortaz Hospital in Yazd, Iran, between 2022 and 2024. Consecutive sampling was employed, and 110 patients were initially enrolled in the study. Ten patients were subsequently excluded because their lesions were located in the mediastinum, resulting in a final sample of 100 patients. Data were collected and analyzed using SPSS software. The study protocol was reviewed and approved by the Ethics Committee of the Ali Ibn Abitaleb School of Medicine (Ethics Code: IR.IAU.YAZD.REC.1403.018).
Results: The findings demonstrated a significant association between lung mass size on CT and both biopsy success and pathological diagnosis. Lesions measuring 10–24 mm and 25–39 mm accounted for 25% and 20% of cases, respectively, whereas lesions measuring ≥40 mm constituted 55% of the study population. The latter group demonstrated the highest biopsy success rate and the highest proportion of malignant pathological diagnoses. In contrast, lesions measuring 25–39 mm showed the highest proportion of benign pathological findings. Other CT characteristics, including lesion morphology (mass, nodule, and consolidation; n = 54, 20, and 26, respectively), were not significantly associated with either biopsy success or pathological findings.
Conclusion: The findings of this study suggest that lung mass size measured on CT may serve as a useful predictor of biopsy success and pathological outcomes in patients undergoing CT-guided lung biopsy. Larger pulmonary lesions, particularly those measuring ≥40 mm, were associated with higher biopsy success rates and a greater proportion of malignant pathological diagnoses. Further studies with larger sample sizes are warranted to validate the predictive value of lesion size and other imaging characteristics for the diagnostic yield of CT-guided lung biopsy.
Methods: This descriptive cross-sectional study was conducted among patients with confirmed lung masses who were referred to Mortaz Hospital in Yazd, Iran, between 2022 and 2024. Consecutive sampling was employed, and 110 patients were initially enrolled in the study. Ten patients were subsequently excluded because their lesions were located in the mediastinum, resulting in a final sample of 100 patients. Data were collected and analyzed using SPSS software. The study protocol was reviewed and approved by the Ethics Committee of the Ali Ibn Abitaleb School of Medicine (Ethics Code: IR.IAU.YAZD.REC.1403.018).
Results: The findings demonstrated a significant association between lung mass size on CT and both biopsy success and pathological diagnosis. Lesions measuring 10–24 mm and 25–39 mm accounted for 25% and 20% of cases, respectively, whereas lesions measuring ≥40 mm constituted 55% of the study population. The latter group demonstrated the highest biopsy success rate and the highest proportion of malignant pathological diagnoses. In contrast, lesions measuring 25–39 mm showed the highest proportion of benign pathological findings. Other CT characteristics, including lesion morphology (mass, nodule, and consolidation; n = 54, 20, and 26, respectively), were not significantly associated with either biopsy success or pathological findings.
Conclusion: The findings of this study suggest that lung mass size measured on CT may serve as a useful predictor of biopsy success and pathological outcomes in patients undergoing CT-guided lung biopsy. Larger pulmonary lesions, particularly those measuring ≥40 mm, were associated with higher biopsy success rates and a greater proportion of malignant pathological diagnoses. Further studies with larger sample sizes are warranted to validate the predictive value of lesion size and other imaging characteristics for the diagnostic yield of CT-guided lung biopsy.
Article number: 1
Type of Study: Original |
Subject:
Special
Received: 2026/05/08 | Accepted: 2026/08/24 | Published: 2026/09/22
Received: 2026/05/08 | Accepted: 2026/08/24 | Published: 2026/09/22
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