Volume 15, Issue 1 (Winter 2026)
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Ethics code: IR.UMSU.REC.1398. 327.
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Mansouri F. Investigation of miRNAs and mRNAs in mesenchymal stem cells for cardiovascular diseases. aumj 2026; 15 (1) : 7
URL: http://aums.abzums.ac.ir/article-1-1934-en.html
URL: http://aums.abzums.ac.ir/article-1-1934-en.html
Department of Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran & Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran , mansouri1600@hotmail.com
Abstract: (31 Views)
Introduction: The prevalence of cardiovascular disease is increasing with the age and the increase in the world's population. Cellular, molecular and physiological changes in the heart and blood vessels can improve heart diseases. Investigating the precise molecular pathogenesis pathways of heart disease can lead to early diagnosis and effective treatment for the disease. Accurate diagnostic biomarkers are very valuable and effective for clinical applications. The present study was conducted to find miRNAs and their target genes.
Methods: The miRNAs and their gene targets in the disease were determined from the GEO and miRDB databases by statistical analysis of p<0.01 and logFC#1. MiRNAs with the most expression changes in angiogenesis were selected. ROC curve analysis for sensitivity and specificity of miRNAs was performed in XLSTAT software version 2016. Ethics Code in Iran IR.UMSU.REC.1398. 327.
Results: The results of statistical analysis showed that 370 miRNAs have different expression. Of these, 180 miRNAs increased in expression, 120 miRNAs decreased in expression, and the others showed no significant change. Analysis of molecular pathways revealed that some of these miRNAs are involved in various processes including angiogenesis, hypoxia, and apoptosis. It was also found that miR-665, miR-216a-5p and miR-34a are important in angiogenesis. For these miRNAs, the ROC analysis determined the area under the curve to be 0.86 with a specificity of 0.89 and a sensitivity of 0.87.
Conclusion: Identification of miRNA changes and the targets of involved genes can increase the therapeutic effects of stem cells and be considered an effective method in the treatment of cardiovascular diseases.
Methods: The miRNAs and their gene targets in the disease were determined from the GEO and miRDB databases by statistical analysis of p<0.01 and logFC#1. MiRNAs with the most expression changes in angiogenesis were selected. ROC curve analysis for sensitivity and specificity of miRNAs was performed in XLSTAT software version 2016. Ethics Code in Iran IR.UMSU.REC.1398. 327.
Results: The results of statistical analysis showed that 370 miRNAs have different expression. Of these, 180 miRNAs increased in expression, 120 miRNAs decreased in expression, and the others showed no significant change. Analysis of molecular pathways revealed that some of these miRNAs are involved in various processes including angiogenesis, hypoxia, and apoptosis. It was also found that miR-665, miR-216a-5p and miR-34a are important in angiogenesis. For these miRNAs, the ROC analysis determined the area under the curve to be 0.86 with a specificity of 0.89 and a sensitivity of 0.87.
Conclusion: Identification of miRNA changes and the targets of involved genes can increase the therapeutic effects of stem cells and be considered an effective method in the treatment of cardiovascular diseases.
Article number: 7
Type of Study: Original |
Subject:
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Received: 2025/08/10 | Accepted: 2026/01/28 | Published: 2026/02/21
Received: 2025/08/10 | Accepted: 2026/01/28 | Published: 2026/02/21
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