Volume 15, Issue 2 (Spring 2026)
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Ethics code: IR.ABZUMS.REC.1401.269
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Sohrabi F, Bastan F, Rashidian M, Mostafavi Montazeri S, Abbasi Khoshsirat N, Alishiri G. Investigating the relationship between COVID-19 vaccine and clinical quantitative and qualitative indicators in ischemic stroke patients. aumj 2026; 15 (2) : 1
URL: http://aums.abzums.ac.ir/article-1-1919-en.html
URL: http://aums.abzums.ac.ir/article-1-1919-en.html
Fatemeh Sohrabi1 
, Fatemeh Bastan1 , Maryam Rashidian2 , Saba Mostafavi Montazeri1 , Nahid Abbasi Khoshsirat *3 
, Goharsharieh Alishiri4
, Fatemeh Bastan1 , Maryam Rashidian2 , Saba Mostafavi Montazeri1 , Nahid Abbasi Khoshsirat *3 , Goharsharieh Alishiri4
1- Student Research Committee, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran
2- Student Research Committee, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran & Alborz Office of the Global Scientific Education and Research Network (USERN), Alborz University of Medical Sciences, Karaj, Iran
3- Department of Neurology, Shahid Rajaee Clinical Research and Development Unit, Alborz University of Medical Sciences, Karaj, Iran ,Nahid.Abbasi.k@gmail.com
4- Students Research Committee, Faculty of School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
2- Student Research Committee, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran & Alborz Office of the Global Scientific Education and Research Network (USERN), Alborz University of Medical Sciences, Karaj, Iran
3- Department of Neurology, Shahid Rajaee Clinical Research and Development Unit, Alborz University of Medical Sciences, Karaj, Iran ,
4- Students Research Committee, Faculty of School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract: (212 Views)
Introduction: Following the emergence of Coronavirus Disease 2019 (COVID-19), several vaccines were developed and authorized for emergency use worldwide. Given the widespread administration of these vaccines and concerns regarding potential neurological and thrombotic adverse events, it is important to evaluate their relationship with cerebrovascular diseases. This study aimed to investigate the clinical characteristics and mortality rate of vaccinated patients with ischemic stroke and compare them with unvaccinated patients.
Methods: This cross-sectional study was conducted on 257 patients with ischemic stroke admitted to Rajaei Hospital, Karaj, Iran, between July and October 2022. Data were collected using a structured checklist based on information obtained from medical records, patients, and their companions. Demographic and clinical characteristics, vaccination status, and outcomes were recorded and analyzed. The study was approved by the Ethics Committee of Alborz University of Medical Sciences (IR.ABZUMS.REC.1401.269).
Results: Univariate analysis demonstrated that age (P = 0.015), thrombocytopenia (P = 0.013), hyperlipidemia (P = 0.056), use of insulin (P = 0.044), atorvastatin (P = 0.015), clopidogrel (P = 0.030), and loss of consciousness (P = 0.037) were associated with COVID-19 vaccine acceptance. In multivariable logistic regression analysis, hyperlipidemia remained the only statistically significant factor associated with vaccine acceptance. Patients with hyperlipidemia were less likely to receive the COVID-19 vaccine than those without hyperlipidemia (P = 0.021, OR = 0.198). No other variables showed a significant independent association with vaccine acceptance.
Conclusion: Hyperlipidemia was significantly associated with COVID-19 vaccine acceptance among patients with ischemic stroke. Understanding factors associated with vaccination behavior in this high-risk population may facilitate the development of targeted educational programs and public health interventions aimed at improving vaccine uptake and reducing the risk of COVID-19-related complications.
Methods: This cross-sectional study was conducted on 257 patients with ischemic stroke admitted to Rajaei Hospital, Karaj, Iran, between July and October 2022. Data were collected using a structured checklist based on information obtained from medical records, patients, and their companions. Demographic and clinical characteristics, vaccination status, and outcomes were recorded and analyzed. The study was approved by the Ethics Committee of Alborz University of Medical Sciences (IR.ABZUMS.REC.1401.269).
Results: Univariate analysis demonstrated that age (P = 0.015), thrombocytopenia (P = 0.013), hyperlipidemia (P = 0.056), use of insulin (P = 0.044), atorvastatin (P = 0.015), clopidogrel (P = 0.030), and loss of consciousness (P = 0.037) were associated with COVID-19 vaccine acceptance. In multivariable logistic regression analysis, hyperlipidemia remained the only statistically significant factor associated with vaccine acceptance. Patients with hyperlipidemia were less likely to receive the COVID-19 vaccine than those without hyperlipidemia (P = 0.021, OR = 0.198). No other variables showed a significant independent association with vaccine acceptance.
Conclusion: Hyperlipidemia was significantly associated with COVID-19 vaccine acceptance among patients with ischemic stroke. Understanding factors associated with vaccination behavior in this high-risk population may facilitate the development of targeted educational programs and public health interventions aimed at improving vaccine uptake and reducing the risk of COVID-19-related complications.
Article number: 1
Keywords: Ischemic Stroke, COVID-19 Vaccines, Vaccine Acceptance, Hyperlipidemias, Mortality, Cerebrovascular Disorders
Type of Study: Original |
Subject:
Special
Received: 2025/05/29 | Accepted: 2025/10/22 | Published: 2026/06/06
Received: 2025/05/29 | Accepted: 2025/10/22 | Published: 2026/06/06
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