Volume 14, Issue 4 (Fall 2025)
aumj 2025, 14(4): 0-0 |
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Research code: 112248541896885760025162834529
Ethics code: IR.IAU.B.REC.1402.115
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Heydari A, Valipour dehnou V, Sharafi deharham F, Roozbahani M. Interactive effect of high-intensity interval training and pollen consumption on depression and some neurotransmitters in the hippocampus of rats exposed to cadmium. aumj 2025; 14 (4) : 6
URL: http://aums.abzums.ac.ir/article-1-1905-en.html
URL: http://aums.abzums.ac.ir/article-1-1905-en.html
1- Department of exercise physiology, Bo. C., Islamic Azad University, Borujerd, Iran
2- Sports Sciences Department, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, Iran ,valipour.v@lu.ac.ir
3- Department of Physical Education and Sports Sciences, Khor. C., Islamic Azad Univercity, Khorramabad, Iran
4- Departement of Motor Behavior, Bo. C., Islamic Azad University, Borujerd, Iran
2- Sports Sciences Department, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, Iran ,
3- Department of Physical Education and Sports Sciences, Khor. C., Islamic Azad Univercity, Khorramabad, Iran
4- Departement of Motor Behavior, Bo. C., Islamic Azad University, Borujerd, Iran
Abstract: (39 Views)
Introduction: Cadmium exposure induces inflammation and disrupts the blood-brain barrier, inhibiting neurotransmitter synthesis and leading to behavioral disorders, including depression. This study examined the combined effects of high-intensity interval training (HIIT) and pollen consumption on depression and neurotransmitter levels in the hippocampus of cadmium-exposed rats.
Methods: Twenty-five rats were randomly assigned to five groups: control, cadmium, pollen, HIIT, and pollen+HIIT. HIIT was performed three times weekly for 8 weeks at 80–110% VO₂ max. Pollen (200 mg/4.2 ml saline) and cadmium chloride (40 mg/kg/day) were administered daily. Depression was assessed via the forced swimming test, and neurotransmitter levels (serotonin, dopamine) and cadmium were measured. Data were analyzed using two-way ANOVA and t-tests (P < 0.05).
Results: The combined effect of HIIT and pollen did not significantly alter serotonin (P = 0.504) or dopamine (P = 0.452) levels. Depression levels (immobility time) also showed no significant interaction (P = 0.112). However, HIIT and pollen alone significantly reduced depression (P < 0.001). The study was approved by the Ethics Committee of the Islamic Azad University (IR.IAU.B.REC.1402.115).
Conclusion: While HIIT and pollen did not significantly affect neurotransmitter levels, they may reduce depression in cadmium-exposed rats by mitigating neuronal damage and enhancing nervous system function.
Methods: Twenty-five rats were randomly assigned to five groups: control, cadmium, pollen, HIIT, and pollen+HIIT. HIIT was performed three times weekly for 8 weeks at 80–110% VO₂ max. Pollen (200 mg/4.2 ml saline) and cadmium chloride (40 mg/kg/day) were administered daily. Depression was assessed via the forced swimming test, and neurotransmitter levels (serotonin, dopamine) and cadmium were measured. Data were analyzed using two-way ANOVA and t-tests (P < 0.05).
Results: The combined effect of HIIT and pollen did not significantly alter serotonin (P = 0.504) or dopamine (P = 0.452) levels. Depression levels (immobility time) also showed no significant interaction (P = 0.112). However, HIIT and pollen alone significantly reduced depression (P < 0.001). The study was approved by the Ethics Committee of the Islamic Azad University (IR.IAU.B.REC.1402.115).
Conclusion: While HIIT and pollen did not significantly affect neurotransmitter levels, they may reduce depression in cadmium-exposed rats by mitigating neuronal damage and enhancing nervous system function.
Article number: 6
Type of Study: Research |
Subject:
Special
Received: 2025/04/04 | Accepted: 2025/09/14 | Published: 2025/10/27
Received: 2025/04/04 | Accepted: 2025/09/14 | Published: 2025/10/27
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