AU - ahmadi, a. AU - zarghami, n. AU - shirazi, h. AU - poorbagher, n. AU - omidfar, k. TI - The Synthesis and Characterization of Magnetic Nano Gold and Their Application for Antibody Immobilization PT - JOURNAL ARTICLE TA - Alborz-Health JN - Alborz-Health VO - 4 VI - 2 IP - 2 4099 - http://aums.abzums.ac.ir/article-1-313-en.html 4100 - http://aums.abzums.ac.ir/article-1-313-en.pdf SO - Alborz-Health 2 ABĀ  - Background: Gold (Au) Fe oxide core-shell nanostructure is a major class of nanoscale material that has attracted a considerable attention due to the biotechnological and biomedical applications and specific properties. Methods: Here we synthesized the magnetite nanoparticles (MNPs) with an average size of 10-12 nm in diameter using the chemical co-precipitation of Fe2+ and Fe3+ in strong alkaline material. Then, an Au coated Fe oxide core-shell nanocomposite with an average diameter of 18-20 nm was produced in the presence of sodium citrate as the reducing agent. The structures of Au shell and magnetic core (Au–Fe oxide) were studied by transmission electron microscopy (TEM), X-ray diffraction (XRD) and fourier transformed infrared spectroscopy (FTIR). Results: Results showed that the NPs were agglomerate-free and shaped regularly, with a narrow sized distribution. The Au-coated Fe oxide NPs exhibited a surface plasmon resonance peak in the range of 500-650 nm with a remarkable peak at 550 nm. Conclusions: Immobilization studies with antibody (Ab) demonstrated that the Au Fe oxide core-shell nanostructure can be used to immobilize Ab, making them valuable for biomedical and biological applications. CP - IRAN IN - Endocrinology research center,Tehran University of Medical Sciences,Iran LG - eng PB - Alborz-Health PG - 129 PT - Research YR - 2015