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:: Volume 5, Issue 4 (Vol.5, No.4, 2016 2016) ::
aumj 2016, 5(4): 242-248 Back to browse issues page
The Protective Effects of Aqueous Extract of Glycyrrhiza Glabra Root Against Liver-related Biochemical Factors Changes Induced by Thioacetamide in Male Rats
D. Moghadamnia , M. Mokhtari , S. Khatamsaz
Department of Biology, Fars Science and Research Branch, Islamic Azad University, Fars, Iran
Abstract:   (625 Views)

Background: Thioacetamide is a liver toxin that causes centrilobular necrosis. In this study, the protective effect of aqueous extract of Glycyrrhiza glabra root against liver-related biochemical factors changes induced by thioacetamide in male rats was investigated.

Materials and Methods: 35 male rats were divided into 5 groups of 7 : control group; sham group: receiving a single dose of 150mg/kg thioacetamide intraperitoneally; experimental groups 1 and 2 and 3: they received the aqueous extract of Glycyrrhiza glabra root at the doses of 100,200,300mg/kg daily orally during 3 months respectively and then a single dose of thioacetamide at 150 mg/kg as intraperitoneal injection . The serum levels of albumin, bilirubin and total protein were measured.

Results: The mean of body weight in all experimental groups receiving aqueous extract of Glycyrrhiza glabra root and thioacetamide did not show significant changes compared to the group receiving thioacetamide. The mean levels of serum bilirubin in all experimental groups receiving aqueous extract of Glycyrrhiza glabra root and thioacetamide did not show significant changes compared to the group receiving thioacetamide. The mean of serum albumin concentration in all experimental groups receiving aqueous extract of Glycyrrhiza glabra root and thioacetamide decreased significantly compared to the group receiving thioacetamide. The mean of serum total protein concentration in experimental groups receiving aqueous extract of Glycyrrhiza glabra root and thioacetamide did not show significant changes compared to the group receiving thioacetamide( p<0. 05).

Conclusion: The results of this study showed that the aqueous extract of Glycyrrhiza glabra root had protective effects against liver-related biochemical factors changes induced by thioacetamide in male rats. 

Keywords: Glycyrrhiza Glabra Root, Thioacetamide, Biochemical Factors, Male Rats
Full-Text [PDF 232 kb]   (211 Downloads)    
Type of Study: Research | Subject: Special
Received: 2017/01/15 | Accepted: 2017/01/15 | Published: 2017/01/15
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Moghadamnia D, Mokhtari M, Khatamsaz S. The Protective Effects of Aqueous Extract of Glycyrrhiza Glabra Root Against Liver-related Biochemical Factors Changes Induced by Thioacetamide in Male Rats. aumj. 2016; 5 (4) :242-248
URL: http://aums.abzums.ac.ir/article-1-508-en.html


Volume 5, Issue 4 (Vol.5, No.4, 2016 2016) Back to browse issues page
نشریه دانشگاه علوم پزشکی البرز Alborz University Medical Journal
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