[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 5, Issue 2 (5-2016) ::
aumj 2016, 5(2): 103-110 Back to browse issues page
Protective Effects Omega3 fish Oil on Disorder of Lipid Function Induced by Thioacetamide in Male Rat
D. Moghadamnia , M. Mokhtari , S. Khatamsaz
Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran , M.mokhtari246@yahoo.com
Abstract:   (1054 Views)

Background: Thioacetamide causes disorder of lipid function . The present study was done to evaluate the protect effects omega3 fish oil supplements on disorder of lipid function induced by thioacetamide in male rats.           

Material and Methods: 42 male rats were divided into 6 groups: Control group, Sham group . Animals of this group received 0/4ml olive oil as a solvent omega3 fish oil supplements orally per day for 3 months. Thioacetamide group. Animals of this group received150 mg/kg of TAA intraperitonealy in a single dose for 3 months. Experimental groups 1,2 and 3. Animals of this groups received 100,200 and 300 mg/kg of omega3 fish oil supplements orally per day for 3 months and 150 mg/kg of TAA intraperitonealy in a single dose for 3months. All animals bled after 3 months. The provided blood samples were tested for total cholesterol, LDL and HDL cholesterol, triglyceride and glucose serum levels by enzymatic methods.            

Results: Pretreatment with 300 mg/kg of omega3 fish oil supplements significant reduced the serum level of total cholesterol comparing with thioacetamide group. Pretreatment with the omega3 fish oil supplements all doses increased the serum level of glucose comparing with thioacetamide group but there was no significant difference. Pretreatment with the omega3 fish oil supplements at all doses showed no significant difference in serum levels of LDL, HDL cholesterol and triglyceride comparing with thioacetamide group.

Conclusion: Therefore, the result show that the protective effects of omega3 fish oil supplements on disorder of lipid function induced by thioacetamide in male rats. The protective effects of omega3 fish oil supplements can be due to their antioxidant effects.

Keywords: Omega3 Fish Oil Supplements, Thioacetamide, Lipid Function, Glucose, Male Rat
Full-Text [PDF 230 kb]   (518 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/06/11 | Accepted: 2016/06/11 | Published: 2016/06/11
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moghadamnia D, Mokhtari M, Khatamsaz S. Protective Effects Omega3 fish Oil on Disorder of Lipid Function Induced by Thioacetamide in Male Rat. aumj. 2016; 5 (2) :103-110
URL: http://aums.abzums.ac.ir/article-1-421-en.html


Volume 5, Issue 2 (5-2016) Back to browse issues page
نشریه دانشگاه علوم پزشکی البرز Alborz University Medical Journal
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3742