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Evaluation of Olive Leaf Extract Effects on Functional and Structural Changes of Liver Tissue Following Lipopolysaccharide Administration in Rats
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Sahar Asghari Bijargah1   , Masoud Alirezaei *  2, Omid Dezfoulian3 |
1- DVM student, School of Veterinary Medicine, Lorestan University, Khorramabad, Iran
2- Division of Biochemistry, School of Veterinary Medicine, Lorestan University, Khorramabad, Iran , Alirezaei_m54@yahoo.com
3- Department of Pathobiology, School of Veterinary Medicine, Lorestan University, Khorramabad, Iran |
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Abstract: (3333 Views) |
Background: Olive leaves are considered as significant sources of bioactive phenolic compounds with superior antioxidant capacity, anti-inflammatory and radical scavenging. The aim of the present study was to evaluate the effects of olive leaf extract on liver tissue following LPS administration.
Materials and Methods: 28 male Wistar rats were divided into control group, LPS, olive leaf extract 40mg/kg BW plus LPS and olive leaf extract 60mg/kg BW plus LPS groups. Control and LPS groups were treated with distilled water and olive leaf extract 40 & 60 mg/kg groups were administrated with olive leaf extract as oral for ten consecutive days. LPS and olive leaf extract groups (40 and 60 mg/kg ) received LPS (Salmonella typhosa,once 5mg/kg) in the 11th day as intraperitoneally.
Results: LPS-induced hepatotoxicity was manifested by a significant elevation in serum levels of ALT and AST enzyme activities and triglyceride concentration in comparision with the control group (P<0.001). Olive leaf extract supplementation, significantly decreased serum activity of ALT and AST enzymes and triglyceride concentration.
Conclusion: Therefore, it seems olive leaf extract containing oleuropein, is able to prevent LPS-induced hepatotoxicity in rats. |
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| Keywords: Olive leaf extract, Oleuropein, Lipopolysaccharide, Oxidative stress, Liver |
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Full-Text [PDF 317 kb]
(1145 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2019/03/08 | Accepted: 2019/03/08 | Published: 2019/03/08
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