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Histopathological Effects of Cumulative Concentrations of Buprenorphine in Hippocampus of Rats
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Mohammad Hossein Dehghan1   , Sepehr Dehghan * 2, Alireza Jalali3 , Ramin Azar Bahram4 |
1- Biochemistry Department, Medical Faculty, Alborz University of Medical Sciences, Kara,j Iran
2- Researcher of Animals Sciences laboratory, Baqiyatallah University of Medical Sciences, Tehran, Iran , isepehrparsa@gmail.com
3- Professor of Cardiovascular Anesthesiology, Baqiyatallah University of Medical Sciences; Tehran, Iran
4- General Practitioner, and a Executive Director, General Editor at Academic Publication Office, Research Department of Alborz University of Medical sciences, Karaj, Iran |
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Abstract: (5552 Views) |
Brain is one of the important members of body that life is impossible without it. The brain is affected easily by different factors like physical, chemical factors agents and disrupts brain function in pons, medulla, spinal cord, central and peripheral nervous system. Buprenorphine is an opioid partial agonist that is used as an analgesic and Drug addiction treatment. This drug is metabolized in liver and Excreted through on number of neuroglia cells, neurons and decrease of area on hippocampus.
In this research, we have been investigated the impact of Ascending doses of buprenorphine on all rats.
in order to perform this research, 35 rats with the same weight range has divided into 7 groups with 5 members that have been injected The drug buprenorphine in 21 days with doses 2,7,10,15,20 and 24 mg/kg and after end of injection, rats were killed by human methods and were sent to laboratory. The results show that intraperitoneal injection of buprenorphine could cause damage on brain tissue.
Based on the results have been obtained from statistical tests. The number of neuroglia cells, neurons and hippocampus area does decrease (p<0.05).
So, it could shown Abuse of buprenorphine will have been faced with brain damages. |
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| Keywords: Hippocampus buprenorphine, Histopathological finding, Baqiyatallah |
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Full-Text [PDF 545 kb]
(1879 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2018/06/15 | Accepted: 2018/06/15 | Published: 2018/06/15
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