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Effect of Summer Savory (Satureja Hortensis L.) on the Concentration of Gonadotropins and Testosterone in Male Rats Exposed to Chronic Immobilization Stress
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Fatemeh Moghaddam1   , Masoumeh Asle-Rousta * 2 |
1- Department of Animal Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
2- Department of Animal Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran , mrousta@iauz.ac.ir |
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Abstract: (3534 Views) |
Background: Summer savory- Satureja hortensis L. is from Lamiaceae family and has antioxidant, anti-inflammatory, anti-apoptotic properties. The purpose of this study is to investigate the effect of hydro-alcoholic extract of Summer Savory leaves on the level of LH, FSH and testosterone in male rats exposed to chronic immobilization stress.
Material and Methods: This study was conducted experimentally. 48 adult male Wistar rats were divided into 6 groups including: Control, Stress, Savory 200, Savory 400, Stress-Savory 200, and Stress-Savory 400. Groups 2, 5, and 6 were placed into restrainer for 6hours per day during 21 consecutive days and groups 3, 4, 5, and 6 were gavaged by hydro-alcoholic extract of Summer Savory with different doses of 200,400mg/kg during 21consecutive days. The level of LH, FSH and testosterone were measured by the end of period.
Results: Chronic Immobilization caused significant decrease in serum concentrations of LH (p<0.01), FSH (p<0.01), and testosterone (p<0.001) in stress group compared with the control group and taking both doses of plant extracts inhibited the above effect.
Conclusion: It is concluded that the Satureja hortensis extract may stimulates the hypothalamic-pituitary-gonadal axis and prevents stress-induced reproductive damages. |
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| Keywords: Summer savory (Satureja hortensis L.), immobilization stress, LH, FSH, testosterone |
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Full-Text [PDF 268 kb]
(1962 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2018/06/15 | Accepted: 2018/06/15 | Published: 2018/06/15
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