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The Study of Testicular Deveplopment in Newborn Male Rats from the Mothers Treated with Maprotiline Hydrochloride Drug
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Elahe Jamali1   , Mehrdad Shariati * 2 |
1- M.Sc in Cell and Developmental Biology, Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
2- Associate Professor, Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran , mehrdadshariati@hotmail.com |
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Abstract: (4106 Views) |
Background: Maprotiline hydrochloride is a norepinephrine reuptake inhibitor; that is using for the treatment of depression. In this research, were studied the effect of maprotiline on changes of the testicular tissue and the concentration of testosterone and gonadotropins in newborn male rats from the mothers treated with this drug.
Materials and Methods: In this experimental study, 40 newborn male rats wistar strain, from pregnant mothers that received 30, 60 and 90 mg/Kg of maprotiline hydrochloride in the three experimental groups orally for pregnancy period that is 21 days. Divided to 5 group of 8 animals. The control group received nothing, and the sham group received solvent. In 22th days after parturition, the newborns weighted and blood samples were taken from the hearts, and concentrations of FSH, LH and testosterone were measured by RIA method. The newborns testes were separated and histological changes were studied.
Results: 60 and 90 mg/kg of maprotiline hydrochloride can be reduced significantly testosterone levels while it increased significantly LH levels compare with control group (p<0.05). FSH levels don’t showed significant changes between the experimental and control groups. Histological examination showed a significant decrease in the sperm density, the number of spermatogonia, primary spermatocytes, spermatids and leydig cells in the experimental groups receiving 60 and 90 mg/kg of the drug, compared to the control group. Also in the experimental groups receiving the drug, with increasing amounts of the drug, decreased body weight and testes weight compared to the control group.
Conclusion: 60 and 90 mg/kg of maprotiline hydrochloride decreases significantly the concentration of testosterone and the number of spermatogenic cells and increases LH levels. |
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| Keywords: Maprotiline hydrochloride, Gonadotropins, Testosterone, Newborn rat |
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Full-Text [PDF 1249 kb]
(1871 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2018/04/07 | Accepted: 2018/04/07 | Published: 2018/04/07
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